Collective Chemotaxis Requires Contact-Dependent Cell Polarity

Eric Theveneau; Lorena Marchant; Sei Kuriyama; Mazhar Gull; Barbara Moepps; Maddy Parsons; Roberto Mayor

doi:10.1016/j.devcel.2010.06.012

Collective Chemotaxis Requires Contact-Dependent Cell Polarity

Eric Theveneau, Lorena Marchant, Sei Kuriyama, Mazhar Gull, Barbara Moepps, Maddy Parsons, Roberto Mayor

Research output: Contribution to journal › Article › peer-review

427 Citations (Scopus)

Abstract

Directional collective migration is now a widely recognized mode of migration during embryogenesis and cancer. However, how a cluster of cells responds to chemoattractants is not fully understood. Neural crest cells are among the most motile cells in the embryo, and their behavior has been likened to malignant invasion. Here, we show that neural crest cells are collectively attracted toward the chemokine Sdf1. While not involved in initially polarizing cells, Sdf1 directionally stabilizes cell protrusions promoted by cell contact. At this cell contact, N-cadherin inhibits protrusion and Rac1 activity and in turn promotes protrusions and activation of Rac1 at the free edge. These results show a role for N-cadherin during contact inhibition of locomotion, and they reveal a mechanism of chemoattraction likely to function during both embryogenesis and cancer metastasis, whereby attractants such as Sdf1 amplify and stabilize contact-dependent

Original language	English
Pages (from-to)	39 - 53
Number of pages	15
Journal	Developmental Cell
Volume	19
Issue number	1
DOIs	https://doi.org/10.1016/j.devcel.2010.06.012
Publication status	Published - Jul 2010

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title = "Collective Chemotaxis Requires Contact-Dependent Cell Polarity",

abstract = "Directional collective migration is now a widely recognized mode of migration during embryogenesis and cancer. However, how a cluster of cells responds to chemoattractants is not fully understood. Neural crest cells are among the most motile cells in the embryo, and their behavior has been likened to malignant invasion. Here, we show that neural crest cells are collectively attracted toward the chemokine Sdf1. While not involved in initially polarizing cells, Sdf1 directionally stabilizes cell protrusions promoted by cell contact. At this cell contact, N-cadherin inhibits protrusion and Rac1 activity and in turn promotes protrusions and activation of Rac1 at the free edge. These results show a role for N-cadherin during contact inhibition of locomotion, and they reveal a mechanism of chemoattraction likely to function during both embryogenesis and cancer metastasis, whereby attractants such as Sdf1 amplify and stabilize contact-dependent",

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T1 - Collective Chemotaxis Requires Contact-Dependent Cell Polarity

AU - Theveneau, Eric

AU - Marchant, Lorena

AU - Kuriyama, Sei

AU - Gull, Mazhar

AU - Moepps, Barbara

AU - Parsons, Maddy

AU - Mayor, Roberto

PY - 2010/7

Y1 - 2010/7

N2 - Directional collective migration is now a widely recognized mode of migration during embryogenesis and cancer. However, how a cluster of cells responds to chemoattractants is not fully understood. Neural crest cells are among the most motile cells in the embryo, and their behavior has been likened to malignant invasion. Here, we show that neural crest cells are collectively attracted toward the chemokine Sdf1. While not involved in initially polarizing cells, Sdf1 directionally stabilizes cell protrusions promoted by cell contact. At this cell contact, N-cadherin inhibits protrusion and Rac1 activity and in turn promotes protrusions and activation of Rac1 at the free edge. These results show a role for N-cadherin during contact inhibition of locomotion, and they reveal a mechanism of chemoattraction likely to function during both embryogenesis and cancer metastasis, whereby attractants such as Sdf1 amplify and stabilize contact-dependent

AB - Directional collective migration is now a widely recognized mode of migration during embryogenesis and cancer. However, how a cluster of cells responds to chemoattractants is not fully understood. Neural crest cells are among the most motile cells in the embryo, and their behavior has been likened to malignant invasion. Here, we show that neural crest cells are collectively attracted toward the chemokine Sdf1. While not involved in initially polarizing cells, Sdf1 directionally stabilizes cell protrusions promoted by cell contact. At this cell contact, N-cadherin inhibits protrusion and Rac1 activity and in turn promotes protrusions and activation of Rac1 at the free edge. These results show a role for N-cadherin during contact inhibition of locomotion, and they reveal a mechanism of chemoattraction likely to function during both embryogenesis and cancer metastasis, whereby attractants such as Sdf1 amplify and stabilize contact-dependent

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DO - 10.1016/j.devcel.2010.06.012

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VL - 19

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JO - Developmental Cell

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Collective Chemotaxis Requires Contact-Dependent Cell Polarity

Abstract

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