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Combination analysis of neuropsychological tests and structural MRI measures in differentiating AD, MCI and control groups-The AddNeuroMed study

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Combination analysis of neuropsychological tests and structural MRI measures in differentiating AD, MCI and control groups-The AddNeuroMed study. / Liu, Yawu; Paajanen, Teemu; Zhang, Yi; Westman, Eric; Wahlund, Lars-Olof; Simmons, Andrew; Tunnard, Catherine; Sobow, Tomasz; Mecocci, Patrizia; Tsolaki, Magda; Vellas, Bruno; Muehlboeck, Sebastian; Evans, Alan; Spenger, Christian; Lovestone, Simon; Soininen, Hilkka.

In: Neurobiology of Aging, Vol. 32, No. 7, 07.2011, p. 1198 - 1206.

Research output: Contribution to journalArticle

Harvard

Liu, Y, Paajanen, T, Zhang, Y, Westman, E, Wahlund, L-O, Simmons, A, Tunnard, C, Sobow, T, Mecocci, P, Tsolaki, M, Vellas, B, Muehlboeck, S, Evans, A, Spenger, C, Lovestone, S & Soininen, H 2011, 'Combination analysis of neuropsychological tests and structural MRI measures in differentiating AD, MCI and control groups-The AddNeuroMed study', Neurobiology of Aging, vol. 32, no. 7, pp. 1198 - 1206. https://doi.org/10.1016/j.neurobiolaging.2009.07.008

APA

Liu, Y., Paajanen, T., Zhang, Y., Westman, E., Wahlund, L-O., Simmons, A., ... Soininen, H. (2011). Combination analysis of neuropsychological tests and structural MRI measures in differentiating AD, MCI and control groups-The AddNeuroMed study. Neurobiology of Aging, 32(7), 1198 - 1206. https://doi.org/10.1016/j.neurobiolaging.2009.07.008

Vancouver

Liu Y, Paajanen T, Zhang Y, Westman E, Wahlund L-O, Simmons A et al. Combination analysis of neuropsychological tests and structural MRI measures in differentiating AD, MCI and control groups-The AddNeuroMed study. Neurobiology of Aging. 2011 Jul;32(7):1198 - 1206. https://doi.org/10.1016/j.neurobiolaging.2009.07.008

Author

Liu, Yawu ; Paajanen, Teemu ; Zhang, Yi ; Westman, Eric ; Wahlund, Lars-Olof ; Simmons, Andrew ; Tunnard, Catherine ; Sobow, Tomasz ; Mecocci, Patrizia ; Tsolaki, Magda ; Vellas, Bruno ; Muehlboeck, Sebastian ; Evans, Alan ; Spenger, Christian ; Lovestone, Simon ; Soininen, Hilkka. / Combination analysis of neuropsychological tests and structural MRI measures in differentiating AD, MCI and control groups-The AddNeuroMed study. In: Neurobiology of Aging. 2011 ; Vol. 32, No. 7. pp. 1198 - 1206.

Bibtex Download

@article{1df7b9d9efb547078b4717de8d893504,
title = "Combination analysis of neuropsychological tests and structural MRI measures in differentiating AD, MCI and control groups-The AddNeuroMed study",
abstract = "To study the ability of neuropsychological tests, manual MRI hippocampal volume measures, regional volume and cortical thickness measures to identify subjects with Alzheimer's disease (AD), mild cognitive impairment (MCI), and healthy age-matched controls. Neuropsychological tests, manual hippocampal volume, automated regional volume and regional cortical thickness measures were performed in 120 AD patients, 120 MCI subjects, and 111 controls. The regional cortical thickness and volumes in MCI subjects were significantly decreased in limbic/paralimbic areas and temporal lobe compared to controls. Atrophy was much more extensive in the AD patients compared to MCI subjects and controls. The combination of neuropsychological tests and volumes revealed the highest accuracy (82{\%} AD vs. MCI; 94{\%} AD vs. control; 83{\%} MCI vs. control). Adding regional cortical thicknesses into the discriminate analysis did not improve accuracy. We conclude that regional cortical thickness and volume measures provide a panoramic view of brain atrophy in AD and MCI subjects. A combination of neuropsychological tests and regional volumes are important when discriminating AD from healthy controls and MCI. (C) 2009 Elsevier Inc. All rights reserved.",
author = "Yawu Liu and Teemu Paajanen and Yi Zhang and Eric Westman and Lars-Olof Wahlund and Andrew Simmons and Catherine Tunnard and Tomasz Sobow and Patrizia Mecocci and Magda Tsolaki and Bruno Vellas and Sebastian Muehlboeck and Alan Evans and Christian Spenger and Simon Lovestone and Hilkka Soininen",
year = "2011",
month = "7",
doi = "10.1016/j.neurobiolaging.2009.07.008",
language = "English",
volume = "32",
pages = "1198 -- 1206",
journal = "Neurobiology of Aging",
issn = "0197-4580",
publisher = "Elsevier B.V.",
number = "7",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Combination analysis of neuropsychological tests and structural MRI measures in differentiating AD, MCI and control groups-The AddNeuroMed study

AU - Liu, Yawu

AU - Paajanen, Teemu

AU - Zhang, Yi

AU - Westman, Eric

AU - Wahlund, Lars-Olof

AU - Simmons, Andrew

AU - Tunnard, Catherine

AU - Sobow, Tomasz

AU - Mecocci, Patrizia

AU - Tsolaki, Magda

AU - Vellas, Bruno

AU - Muehlboeck, Sebastian

AU - Evans, Alan

AU - Spenger, Christian

AU - Lovestone, Simon

AU - Soininen, Hilkka

PY - 2011/7

Y1 - 2011/7

N2 - To study the ability of neuropsychological tests, manual MRI hippocampal volume measures, regional volume and cortical thickness measures to identify subjects with Alzheimer's disease (AD), mild cognitive impairment (MCI), and healthy age-matched controls. Neuropsychological tests, manual hippocampal volume, automated regional volume and regional cortical thickness measures were performed in 120 AD patients, 120 MCI subjects, and 111 controls. The regional cortical thickness and volumes in MCI subjects were significantly decreased in limbic/paralimbic areas and temporal lobe compared to controls. Atrophy was much more extensive in the AD patients compared to MCI subjects and controls. The combination of neuropsychological tests and volumes revealed the highest accuracy (82% AD vs. MCI; 94% AD vs. control; 83% MCI vs. control). Adding regional cortical thicknesses into the discriminate analysis did not improve accuracy. We conclude that regional cortical thickness and volume measures provide a panoramic view of brain atrophy in AD and MCI subjects. A combination of neuropsychological tests and regional volumes are important when discriminating AD from healthy controls and MCI. (C) 2009 Elsevier Inc. All rights reserved.

AB - To study the ability of neuropsychological tests, manual MRI hippocampal volume measures, regional volume and cortical thickness measures to identify subjects with Alzheimer's disease (AD), mild cognitive impairment (MCI), and healthy age-matched controls. Neuropsychological tests, manual hippocampal volume, automated regional volume and regional cortical thickness measures were performed in 120 AD patients, 120 MCI subjects, and 111 controls. The regional cortical thickness and volumes in MCI subjects were significantly decreased in limbic/paralimbic areas and temporal lobe compared to controls. Atrophy was much more extensive in the AD patients compared to MCI subjects and controls. The combination of neuropsychological tests and volumes revealed the highest accuracy (82% AD vs. MCI; 94% AD vs. control; 83% MCI vs. control). Adding regional cortical thicknesses into the discriminate analysis did not improve accuracy. We conclude that regional cortical thickness and volume measures provide a panoramic view of brain atrophy in AD and MCI subjects. A combination of neuropsychological tests and regional volumes are important when discriminating AD from healthy controls and MCI. (C) 2009 Elsevier Inc. All rights reserved.

U2 - 10.1016/j.neurobiolaging.2009.07.008

DO - 10.1016/j.neurobiolaging.2009.07.008

M3 - Article

VL - 32

SP - 1198

EP - 1206

JO - Neurobiology of Aging

JF - Neurobiology of Aging

SN - 0197-4580

IS - 7

ER -

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