@article{ccc6d9535a5740efbe0da85e5d119f59,
title = "Combined diffusion-relaxometry microstructure imaging: Current status and future prospects",
abstract = "Microstructure imaging seeks to noninvasively measure and map microscopic tissue features by pairing mathematical modeling with tailored MRI protocols. This article reviews an emerging paradigm that has the potential to provide a more detailed assessment of tissue microstructure—combined diffusion-relaxometry imaging. Combined diffusion-relaxometry acquisitions vary multiple MR contrast encodings—such as b-value, gradient direction, inversion time, and echo time—in a multidimensional acquisition space. When paired with suitable analysis techniques, this enables quantification of correlations and coupling between multiple MR parameters—such as diffusivity, (Formula presented.), (Formula presented.), and (Formula presented.). This opens the possibility of disentangling multiple tissue compartments (within voxels) that are indistinguishable with single-contrast scans, enabling a new generation of microstructural maps with improved biological sensitivity and specificity.",
keywords = "diffusion, multidimensional MRI, quantitative MRI, relaxometry",
author = "Slator, {Paddy J.} and Marco Palombo and Miller, {Karla L.} and Westin, {Carl Fredrik} and Frederik Laun and Daeun Kim and Haldar, {Justin P.} and Dan Benjamini and Gregory Lemberskiy and {de Almeida Martins}, {Joao P.} and Jana Hutter",
note = "Funding Information: This work was supported by the NIH Human Placenta Project grant 1U01HD087202-01 (Placenta Imaging Project [PiP]); the Wellcome EPSRC Centre for Medical Engineering at Kings College London (WT 203148/Z/16/Z); the National Institute for Health Research (NIHR) Biomedical Research Centre based at Guy?s and St Thomas? NHS Foundation Trust and Kings? College London; and the NIHR Biomedical Research Centre at University College London Hospitals NHS Foundation Trust and University College London. The views expressed are those of the authors and not necessarily those of the NHS, the NIHR or the Department of Health. PJS was funded by the European Union?s Horizon 2020 research and innovation programme under grant agreement No. 666992. MP was supported by EPSRC grant EP/N018702/1 and by UKRI Future Leaders Fellowship MR/T020296/1. CFW was funded by NIH grants P41EB015902 and R01MH074794. FBL was funded by the Deutsche Forschungsgemeinschaft (DFG LA 2804/12-1). DK and JPH were funded by NIH grants R01NS074980 and R01MH116173. DB was supported by a grant from the U.S. Department of Defense, Program Project 308430 - Uniformed Services University of the Health Sciences. JH was supported by Wellcome Trust Sir Henry Wellcome Fellowship 201374/Z/16/Z and UKRI Future Leaders Fellowship MR/T018119/1. The authors thank the ISMRM for supporting their combined diffusion-relaxometry microstructure imaging member-initiated symposium at the ISMRM 2019 Annual Meeting & Exhibition. Funding Information: This work was supported by the NIH Human Placenta Project grant 1U01HD087202‐01 (Placenta Imaging Project [PiP]); the Wellcome EPSRC Centre for Medical Engineering at Kings College London (WT 203148/Z/16/Z); the National Institute for Health Research (NIHR) Biomedical Research Centre based at Guy{\textquoteright}s and St Thomas{\textquoteright} NHS Foundation Trust and Kings{\textquoteright} College London; and the NIHR Biomedical Research Centre at University College London Hospitals NHS Foundation Trust and University College London. The views expressed are those of the authors and not necessarily those of the NHS, the NIHR or the Department of Health. PJS was funded by the European Union{\textquoteright}s Horizon 2020 research and innovation programme under grant agreement No. 666992. MP was supported by EPSRC grant EP/N018702/1 and by UKRI Future Leaders Fellowship MR/T020296/1. CFW was funded by NIH grants P41EB015902 and R01MH074794. FBL was funded by the Deutsche Forschungsgemeinschaft (DFG LA 2804/12‐1). DK and JPH were funded by NIH grants R01NS074980 and R01MH116173. DB was supported by a grant from the U.S. Department of Defense, Program Project 308430 ‐ Uniformed Services University of the Health Sciences. JH was supported by Wellcome Trust Sir Henry Wellcome Fellowship 201374/Z/16/Z and UKRI Future Leaders Fellowship MR/T018119/1. Publisher Copyright: {\textcopyright} 2021 The Authors. Magnetic Resonance in Medicine published by Wiley Periodicals LLC on behalf of International Society for Magnetic Resonance in Medicine",
year = "2021",
month = dec,
doi = "10.1002/mrm.28963",
language = "English",
volume = "86",
pages = "2987--3011",
journal = "Magnetic Resonance in Medicine",
issn = "0740-3194",
publisher = "WILEY-BLACKWELL",
number = "6",
}