Combining anti-cancer drugs with artificial sweeteners: Synthesis and anti-cancer activity of saccharinate (sac) and thiosaccharinate (tsac) complexes cis-[Pt(sac)2(NH3)2] and cis-[Pt(tsac)2(NH3)2]

Subhi A. Al-jibori; Ghassan H. Al-jibori; Lamaan J. Al-hayaly; Christoph Wagner; Harry Schmidt; Suna Timur; F. Baris Barlas; Elif Subasi; Shishir Ghosh; Graeme Hogarth

doi:10.1016/j.jinorgbio.2014.07.017

Combining anti-cancer drugs with artificial sweeteners: Synthesis and anti-cancer activity of saccharinate (sac) and thiosaccharinate (tsac) complexes cis-[Pt(sac)2(NH3)2] and cis-[Pt(tsac)2(NH3)2]

Subhi A. Al-jibori, Ghassan H. Al-jibori, Lamaan J. Al-hayaly, Christoph Wagner, Harry Schmidt, Suna Timur, F. Baris Barlas, Elif Subasi, Shishir Ghosh, Graeme Hogarth

Chemistry

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Abstract

The new platinum(II) complexes cis-[Pt(sac)2(NH3)2] (sac = saccharinate) and cis-[Pt(tsac)2(NH3)2] (tsac = thiosaccharinate) have been prepared, the X-ray crystal structure of cis-[Pt(sac)2(NH3)2].H2O reveals that both saccharinate anions are N-bound in a cis-arrangement being inequivalent in both the solid-state and in solution at room temperature. Preliminary anti-cancer activity has been assessed against A549 human alveolar type-II like cell lines with the thiosaccharinate complex showing good activity.

Original language	English
Pages (from-to)	55-57
Number of pages	3
Journal	Journal of Inorganic Biochemistry
Volume	141
Early online date	1 Aug 2014
DOIs	https://doi.org/10.1016/j.jinorgbio.2014.07.017
Publication status	Published - 1 Dec 2014

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10.1016/j.jinorgbio.2014.07.017

Combining anti-cancer drugs with_AL-JIBORI_Accepted22July2014_GREEN AAM
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http://linkinghub.elsevier.com/retrieve/pii/S0162013414002074

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Al-jibori, S. A., Al-jibori, G. H., Al-hayaly, L. J., Wagner, C., Schmidt, H., Timur, S., Baris Barlas, F., Subasi, E., Ghosh, S., & Hogarth, G. (2014). Combining anti-cancer drugs with artificial sweeteners: Synthesis and anti-cancer activity of saccharinate (sac) and thiosaccharinate (tsac) complexes cis-[Pt(sac)2(NH3)2] and cis-[Pt(tsac)2(NH3)2]. Journal of Inorganic Biochemistry, 141, 55-57. https://doi.org/10.1016/j.jinorgbio.2014.07.017

@article{91e4c37e89a24912a12fcdf45385b68a,

title = "Combining anti-cancer drugs with artificial sweeteners: Synthesis and anti-cancer activity of saccharinate (sac) and thiosaccharinate (tsac) complexes cis-[Pt(sac)2(NH3)2] and cis-[Pt(tsac)2(NH3)2]",

abstract = "The new platinum(II) complexes cis-[Pt(sac)2(NH3)2] (sac = saccharinate) and cis-[Pt(tsac)2(NH3)2] (tsac = thiosaccharinate) have been prepared, the X-ray crystal structure of cis-[Pt(sac)2(NH3)2].H2O reveals that both saccharinate anions are N-bound in a cis-arrangement being inequivalent in both the solid-state and in solution at room temperature. Preliminary anti-cancer activity has been assessed against A549 human alveolar type-II like cell lines with the thiosaccharinate complex showing good activity.",

author = "Al-jibori, {Subhi A.} and Al-jibori, {Ghassan H.} and Al-hayaly, {Lamaan J.} and Christoph Wagner and Harry Schmidt and Suna Timur and {Baris Barlas}, F. and Elif Subasi and Shishir Ghosh and Graeme Hogarth",

year = "2014",

month = dec,

day = "1",

doi = "10.1016/j.jinorgbio.2014.07.017",

language = "English",

volume = "141",

pages = "55--57",

journal = "Journal of Inorganic Biochemistry",

issn = "0162-0134",

publisher = "Elsevier Inc.",

}

Al-jibori, SA, Al-jibori, GH, Al-hayaly, LJ, Wagner, C, Schmidt, H, Timur, S, Baris Barlas, F, Subasi, E, Ghosh, S & Hogarth, G 2014, 'Combining anti-cancer drugs with artificial sweeteners: Synthesis and anti-cancer activity of saccharinate (sac) and thiosaccharinate (tsac) complexes cis-[Pt(sac)2(NH3)2] and cis-[Pt(tsac)2(NH3)2]', Journal of Inorganic Biochemistry, vol. 141, pp. 55-57. https://doi.org/10.1016/j.jinorgbio.2014.07.017

Combining anti-cancer drugs with artificial sweeteners: Synthesis and anti-cancer activity of saccharinate (sac) and thiosaccharinate (tsac) complexes cis-[Pt(sac)2(NH3)2] and cis-[Pt(tsac)2(NH3)2]. / Al-jibori, Subhi A.; Al-jibori, Ghassan H.; Al-hayaly, Lamaan J. et al.
In: Journal of Inorganic Biochemistry, Vol. 141, 01.12.2014, p. 55-57.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Combining anti-cancer drugs with artificial sweeteners

T2 - Synthesis and anti-cancer activity of saccharinate (sac) and thiosaccharinate (tsac) complexes cis-[Pt(sac)2(NH3)2] and cis-[Pt(tsac)2(NH3)2]

AU - Al-jibori, Subhi A.

AU - Al-jibori, Ghassan H.

AU - Al-hayaly, Lamaan J.

AU - Wagner, Christoph

AU - Schmidt, Harry

AU - Timur, Suna

AU - Baris Barlas, F.

AU - Subasi, Elif

AU - Ghosh, Shishir

AU - Hogarth, Graeme

PY - 2014/12/1

Y1 - 2014/12/1

N2 - The new platinum(II) complexes cis-[Pt(sac)2(NH3)2] (sac = saccharinate) and cis-[Pt(tsac)2(NH3)2] (tsac = thiosaccharinate) have been prepared, the X-ray crystal structure of cis-[Pt(sac)2(NH3)2].H2O reveals that both saccharinate anions are N-bound in a cis-arrangement being inequivalent in both the solid-state and in solution at room temperature. Preliminary anti-cancer activity has been assessed against A549 human alveolar type-II like cell lines with the thiosaccharinate complex showing good activity.

AB - The new platinum(II) complexes cis-[Pt(sac)2(NH3)2] (sac = saccharinate) and cis-[Pt(tsac)2(NH3)2] (tsac = thiosaccharinate) have been prepared, the X-ray crystal structure of cis-[Pt(sac)2(NH3)2].H2O reveals that both saccharinate anions are N-bound in a cis-arrangement being inequivalent in both the solid-state and in solution at room temperature. Preliminary anti-cancer activity has been assessed against A549 human alveolar type-II like cell lines with the thiosaccharinate complex showing good activity.

U2 - 10.1016/j.jinorgbio.2014.07.017

DO - 10.1016/j.jinorgbio.2014.07.017

M3 - Article

SN - 0162-0134

VL - 141

SP - 55

EP - 57

JO - Journal of Inorganic Biochemistry

JF - Journal of Inorganic Biochemistry

ER -

Al-jibori SA, Al-jibori GH, Al-hayaly LJ, Wagner C, Schmidt H, Timur S et al. Combining anti-cancer drugs with artificial sweeteners: Synthesis and anti-cancer activity of saccharinate (sac) and thiosaccharinate (tsac) complexes cis-[Pt(sac)2(NH3)2] and cis-[Pt(tsac)2(NH3)2]. Journal of Inorganic Biochemistry. 2014 Dec 1;141:55-57. Epub 2014 Aug 1. doi: 10.1016/j.jinorgbio.2014.07.017

Combining anti-cancer drugs with artificial sweeteners: Synthesis and anti-cancer activity of saccharinate (sac) and thiosaccharinate (tsac) complexes cis-[Pt(sac)2(NH3)2] and cis-[Pt(tsac)2(NH3)2]

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