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Comment on 'Numerical assessment and comparison of pulse wave velocity methods aiming at measuring aortic stiffness'

Research output: Contribution to journalComment/debate

Original languageEnglish
Article number078001
JournalPhysiological Measurement
Issue number7
Early online date5 Jun 2018
StatePublished - 6 Jul 2018


  • PTT comment preprint

    PTT_comment_preprint.pdf, 251 KB, application/pdf


    Submitted manuscript


    This is a peer-reviewed, un-copyedited version of an article published in Physiological Measurement. IOP Publishing Ltd is not responsible for any errors or omissions in this version of the manuscript or any version derived from it. The Version of Record is available online at DOI: 10.1088/1361-6579/aaca80,

King's Authors


A recent numerical study investigated the potential utility of peripheral PWV measurements for assessing aortic stiffness by simulating pulse wave propagation through the arterial tree. In this Comment we provide additional analysis of the simulations in which arterial compliances were changed. The analysis indicates that relationships between aortic and peripheral pulse transit times (PTTs) may not be constant when compliances change. Consequently, peripheral PWV measurements may have greatest utility in particular clinical settings in which either: an assumption can be made about possible changes in compliance, allowing aortic PTT to be estimated from peripheral PTT; or, one wishes to assess changes in peripheral PWV over time.

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