Commentary: RCT of optimal dose methylphenidate in children and adolescents with severe ADHD and ID - a reply to Arnold (2013)

TY - JOUR

T1 - Commentary: RCT of optimal dose methylphenidate in children and adolescents with severe ADHD and ID - a reply to Arnold (2013)

AU - Simonoff, Emily

AU - Taylor, Eric

AU - Baird, Gillian

AU - Bernard, Sarah

PY - 2013/6

Y1 - 2013/6

N2 - The commentary by Arnold (2013) raises a number of interesting issues and speculations about the action of methylphenidate in children with intellectual disability (ID) and associated neurodevelopmental disorders, such as autism spectrum disorders. In our article (Simonoff etal., 2013), we were careful to stick closely to the statistical analysis plan drawn up (and approved by the Data Monitoring Committee) during data collection and prior to any exploratory analysis. However, a number of the issues raised by Arnold warrant further response, with the aim of clarifying the lessons that can reasonably be drawn for clinical practice.

AB - The commentary by Arnold (2013) raises a number of interesting issues and speculations about the action of methylphenidate in children with intellectual disability (ID) and associated neurodevelopmental disorders, such as autism spectrum disorders. In our article (Simonoff etal., 2013), we were careful to stick closely to the statistical analysis plan drawn up (and approved by the Data Monitoring Committee) during data collection and prior to any exploratory analysis. However, a number of the issues raised by Arnold warrant further response, with the aim of clarifying the lessons that can reasonably be drawn for clinical practice.

KW - HYPERACTIVITY

KW - DISORDERS

KW - TRIAL

KW - Acknowledged-BRC

KW - Acknowledged-BRC-13/14

U2 - 10.1111/jcpp.12098

DO - 10.1111/jcpp.12098

M3 - Comment/debate

SN - 0021-9630

VL - 54

SP - 703

EP - 704

JO - Journal of Child Psychology and Psychiatry

JF - Journal of Child Psychology and Psychiatry

IS - 6

ER -