Common genetic variation in the 3'-BCL11B gene desert is associated with carotid-femoral pulse wave velocity and excess cardiovascular disease risk: the AortaGen Consortium

Gary F Mitchell; Germaine C Verwoert; Kirill V Tarasov; Aaron Isaacs; Albert V Smith; [No Value] Yasmin; Ernst R Rietzschel; Toshiko Tanaka; Yongmei Liu; Afshin Parsa; Samer S Najjar; Kevin M O'Shaughnessy; Sigurdur Sigurdsson; Marc L De Buyzere; Martin G Larson; Mark P S Sie; Jeanette S Andrews; Wendy S Post; Francesco U S Mattace-Raso; Carmel M McEniery; Gudny Eiriksdottir; Patrick Segers; Ramachandran S Vasan; Marie Josee E van Rijn; Timothy D Howard; Patrick F McArdle; Abbas Dehghan; Elizabeth S Jewell; Stephen J Newhouse; Sofie Bekaert; Naomi M Hamburg; Anne B Newman; Albert Hofman; Angelo Scuteri; Dirk De Bacquer; Mohammad Arfan Ikram; Bruce M Psaty; Christian Fuchsberger; Matthias Olden; Louise V Wain; Paul Elliott; Nicholas L Smith; Janine F Felix; Jeanette Erdmann; Joseph A Vita; Kim Sutton-Tyrrell; Eric J G Sijbrands; Serena Sanna; Lenore J Launer; Tim De Meyer; Andrew D Johnson; Anna F C Schut; David M Herrington; Fernando Rivadeneira; Manuela Uda; Ian B Wilkinson; Thor Aspelund; Thierry C Gillebert; Luc Van Bortel; Emelia J Benjamin; Ben A Oostra; Jingzhong Ding; Quince Gibson; André G Uitterlinden; Gonçalo R Abecasis; John R Cockcroft; Vilmundur Gudnason; Guy G De Backer; Luigi Ferrucci; Tamara B Harris; Alan R Shuldiner; Cornelia M van Duijn; Daniel Levy; Edward G Lakatta; Jacqueline C M Witteman; Richard Dobson

doi:10.1161/CIRCGENETICS.111.959817

Common genetic variation in the 3'-BCL11B gene desert is associated with carotid-femoral pulse wave velocity and excess cardiovascular disease risk: the AortaGen Consortium

Gary F Mitchell, Germaine C Verwoert, Kirill V Tarasov, Aaron Isaacs, Albert V Smith, [No Value] Yasmin, Ernst R Rietzschel, Toshiko Tanaka, Yongmei Liu, Afshin Parsa, Samer S Najjar, Kevin M O'Shaughnessy, Sigurdur Sigurdsson, Marc L De Buyzere, Martin G Larson, Mark P S Sie, Jeanette S Andrews, Wendy S Post, Francesco U S Mattace-Raso, Carmel M McEnieryGudny Eiriksdottir, Patrick Segers, Ramachandran S Vasan, Marie Josee E van Rijn, Timothy D Howard, Patrick F McArdle, Abbas Dehghan, Elizabeth S Jewell, Stephen J Newhouse, Sofie Bekaert, Naomi M Hamburg, Anne B Newman, Albert Hofman, Angelo Scuteri, Dirk De Bacquer, Mohammad Arfan Ikram, Bruce M Psaty, Christian Fuchsberger, Matthias Olden, Louise V Wain, Paul Elliott, Nicholas L Smith, Janine F Felix, Jeanette Erdmann, Joseph A Vita, Kim Sutton-Tyrrell, Eric J G Sijbrands, Serena Sanna, Lenore J Launer, Tim De Meyer, Andrew D Johnson, Anna F C Schut, David M Herrington, Fernando Rivadeneira, Manuela Uda, Ian B Wilkinson, Thor Aspelund, Thierry C Gillebert, Luc Van Bortel, Emelia J Benjamin, Ben A Oostra, Jingzhong Ding, Quince Gibson, André G Uitterlinden, Gonçalo R Abecasis, John R Cockcroft, Vilmundur Gudnason, Guy G De Backer, Luigi Ferrucci, Tamara B Harris, Alan R Shuldiner, Cornelia M van Duijn, Daniel Levy, Edward G Lakatta, Jacqueline C M Witteman, Richard Dobson

Research output: Contribution to journal › Article › peer-review

82 Citations (Scopus)

Abstract

Carotid-femoral pulse wave velocity (CFPWV) is a heritable measure of aortic stiffness that is strongly associated with increased risk for major cardiovascular disease events.

Original language	English
Pages (from-to)	81-90
Number of pages	10
Journal	Circulation-Cardiovascular Genetics
Volume	5
Issue number	1
DOIs	https://doi.org/10.1161/CIRCGENETICS.111.959817
Publication status	Published - 2012

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10.1161/CIRCGENETICS.111.959817

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Mitchell, G. F., Verwoert, G. C., Tarasov, K. V., Isaacs, A., Smith, A. V., Yasmin, N. V., Rietzschel, E. R., Tanaka, T., Liu, Y., Parsa, A., Najjar, S. S., O'Shaughnessy, K. M., Sigurdsson, S., De Buyzere, M. L., Larson, M. G., Sie, M. P. S., Andrews, J. S., Post, W. S., Mattace-Raso, F. U. S., ... Dobson, R. (2012). Common genetic variation in the 3'-BCL11B gene desert is associated with carotid-femoral pulse wave velocity and excess cardiovascular disease risk: the AortaGen Consortium. Circulation-Cardiovascular Genetics, 5(1), 81-90. https://doi.org/10.1161/CIRCGENETICS.111.959817

@article{0cabf91fc09c4382971cf538681b89ec,

title = "Common genetic variation in the 3'-BCL11B gene desert is associated with carotid-femoral pulse wave velocity and excess cardiovascular disease risk: the AortaGen Consortium",

abstract = "Carotid-femoral pulse wave velocity (CFPWV) is a heritable measure of aortic stiffness that is strongly associated with increased risk for major cardiovascular disease events.",

author = "Mitchell, {Gary F} and Verwoert, {Germaine C} and Tarasov, {Kirill V} and Aaron Isaacs and Smith, {Albert V} and Yasmin, {[No Value]} and Rietzschel, {Ernst R} and Toshiko Tanaka and Yongmei Liu and Afshin Parsa and Najjar, {Samer S} and O'Shaughnessy, {Kevin M} and Sigurdur Sigurdsson and {De Buyzere}, {Marc L} and Larson, {Martin G} and Sie, {Mark P S} and Andrews, {Jeanette S} and Post, {Wendy S} and Mattace-Raso, {Francesco U S} and McEniery, {Carmel M} and Gudny Eiriksdottir and Patrick Segers and Vasan, {Ramachandran S} and {van Rijn}, {Marie Josee E} and Howard, {Timothy D} and McArdle, {Patrick F} and Abbas Dehghan and Jewell, {Elizabeth S} and Newhouse, {Stephen J} and Sofie Bekaert and Hamburg, {Naomi M} and Newman, {Anne B} and Albert Hofman and Angelo Scuteri and {De Bacquer}, Dirk and Ikram, {Mohammad Arfan} and Psaty, {Bruce M} and Christian Fuchsberger and Matthias Olden and Wain, {Louise V} and Paul Elliott and Smith, {Nicholas L} and Felix, {Janine F} and Jeanette Erdmann and Vita, {Joseph A} and Kim Sutton-Tyrrell and Sijbrands, {Eric J G} and Serena Sanna and Launer, {Lenore J} and {De Meyer}, Tim and Johnson, {Andrew D} and Schut, {Anna F C} and Herrington, {David M} and Fernando Rivadeneira and Manuela Uda and Wilkinson, {Ian B} and Thor Aspelund and Gillebert, {Thierry C} and {Van Bortel}, Luc and Benjamin, {Emelia J} and Oostra, {Ben A} and Jingzhong Ding and Quince Gibson and Uitterlinden, {Andr{\'e} G} and Abecasis, {Gon{\c c}alo R} and Cockcroft, {John R} and Vilmundur Gudnason and {De Backer}, {Guy G} and Luigi Ferrucci and Harris, {Tamara B} and Shuldiner, {Alan R} and {van Duijn}, {Cornelia M} and Daniel Levy and Lakatta, {Edward G} and Witteman, {Jacqueline C M} and Richard Dobson",

year = "2012",

doi = "10.1161/CIRCGENETICS.111.959817",

language = "English",

volume = "5",

pages = "81--90",

journal = "Circulation-Cardiovascular Genetics",

publisher = "American Heart Association, Inc.",

number = "1",

}

Mitchell, GF, Verwoert, GC, Tarasov, KV, Isaacs, A, Smith, AV, Yasmin, NV, Rietzschel, ER, Tanaka, T, Liu, Y, Parsa, A, Najjar, SS, O'Shaughnessy, KM, Sigurdsson, S, De Buyzere, ML, Larson, MG, Sie, MPS, Andrews, JS, Post, WS, Mattace-Raso, FUS, McEniery, CM, Eiriksdottir, G, Segers, P, Vasan, RS, van Rijn, MJE, Howard, TD, McArdle, PF, Dehghan, A, Jewell, ES, Newhouse, SJ, Bekaert, S, Hamburg, NM, Newman, AB, Hofman, A, Scuteri, A, De Bacquer, D, Ikram, MA, Psaty, BM, Fuchsberger, C, Olden, M, Wain, LV, Elliott, P, Smith, NL, Felix, JF, Erdmann, J, Vita, JA, Sutton-Tyrrell, K, Sijbrands, EJG, Sanna, S, Launer, LJ, De Meyer, T, Johnson, AD, Schut, AFC, Herrington, DM, Rivadeneira, F, Uda, M, Wilkinson, IB, Aspelund, T, Gillebert, TC, Van Bortel, L, Benjamin, EJ, Oostra, BA, Ding, J, Gibson, Q, Uitterlinden, AG, Abecasis, GR, Cockcroft, JR, Gudnason, V, De Backer, GG, Ferrucci, L, Harris, TB, Shuldiner, AR, van Duijn, CM, Levy, D, Lakatta, EG, Witteman, JCM & Dobson, R 2012, 'Common genetic variation in the 3'-BCL11B gene desert is associated with carotid-femoral pulse wave velocity and excess cardiovascular disease risk: the AortaGen Consortium', Circulation-Cardiovascular Genetics, vol. 5, no. 1, pp. 81-90. https://doi.org/10.1161/CIRCGENETICS.111.959817

Common genetic variation in the 3'-BCL11B gene desert is associated with carotid-femoral pulse wave velocity and excess cardiovascular disease risk: the AortaGen Consortium. / Mitchell, Gary F; Verwoert, Germaine C; Tarasov, Kirill V et al.
In: Circulation-Cardiovascular Genetics, Vol. 5, No. 1, 2012, p. 81-90.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Common genetic variation in the 3'-BCL11B gene desert is associated with carotid-femoral pulse wave velocity and excess cardiovascular disease risk

T2 - the AortaGen Consortium

AU - Mitchell, Gary F

AU - Verwoert, Germaine C

AU - Tarasov, Kirill V

AU - Isaacs, Aaron

AU - Smith, Albert V

AU - Yasmin, [No Value]

AU - Rietzschel, Ernst R

AU - Tanaka, Toshiko

AU - Liu, Yongmei

AU - Parsa, Afshin

AU - Najjar, Samer S

AU - O'Shaughnessy, Kevin M

AU - Sigurdsson, Sigurdur

AU - De Buyzere, Marc L

AU - Larson, Martin G

AU - Sie, Mark P S

AU - Andrews, Jeanette S

AU - Post, Wendy S

AU - Mattace-Raso, Francesco U S

AU - McEniery, Carmel M

AU - Eiriksdottir, Gudny

AU - Segers, Patrick

AU - Vasan, Ramachandran S

AU - van Rijn, Marie Josee E

AU - Howard, Timothy D

AU - McArdle, Patrick F

AU - Dehghan, Abbas

AU - Jewell, Elizabeth S

AU - Newhouse, Stephen J

AU - Bekaert, Sofie

AU - Hamburg, Naomi M

AU - Newman, Anne B

AU - Hofman, Albert

AU - Scuteri, Angelo

AU - De Bacquer, Dirk

AU - Ikram, Mohammad Arfan

AU - Psaty, Bruce M

AU - Fuchsberger, Christian

AU - Olden, Matthias

AU - Wain, Louise V

AU - Elliott, Paul

AU - Smith, Nicholas L

AU - Felix, Janine F

AU - Erdmann, Jeanette

AU - Vita, Joseph A

AU - Sutton-Tyrrell, Kim

AU - Sijbrands, Eric J G

AU - Sanna, Serena

AU - Launer, Lenore J

AU - De Meyer, Tim

AU - Johnson, Andrew D

AU - Schut, Anna F C

AU - Herrington, David M

AU - Rivadeneira, Fernando

AU - Uda, Manuela

AU - Wilkinson, Ian B

AU - Aspelund, Thor

AU - Gillebert, Thierry C

AU - Van Bortel, Luc

AU - Benjamin, Emelia J

AU - Oostra, Ben A

AU - Ding, Jingzhong

AU - Gibson, Quince

AU - Uitterlinden, André G

AU - Abecasis, Gonçalo R

AU - Cockcroft, John R

AU - Gudnason, Vilmundur

AU - De Backer, Guy G

AU - Ferrucci, Luigi

AU - Harris, Tamara B

AU - Shuldiner, Alan R

AU - van Duijn, Cornelia M

AU - Levy, Daniel

AU - Lakatta, Edward G

AU - Witteman, Jacqueline C M

AU - Dobson, Richard

PY - 2012

Y1 - 2012

N2 - Carotid-femoral pulse wave velocity (CFPWV) is a heritable measure of aortic stiffness that is strongly associated with increased risk for major cardiovascular disease events.

AB - Carotid-femoral pulse wave velocity (CFPWV) is a heritable measure of aortic stiffness that is strongly associated with increased risk for major cardiovascular disease events.

U2 - 10.1161/CIRCGENETICS.111.959817

DO - 10.1161/CIRCGENETICS.111.959817

M3 - Article

C2 - 22068335

VL - 5

SP - 81

EP - 90

JO - Circulation-Cardiovascular Genetics

JF - Circulation-Cardiovascular Genetics

IS - 1

ER -

Common genetic variation in the 3'-BCL11B gene desert is associated with carotid-femoral pulse wave velocity and excess cardiovascular disease risk: the AortaGen Consortium

Abstract

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