Common structural correlates of trait impulsiveness and perceptual reasoning in adolescence

Christina Schilling; Simone Kuehn; Alexander Romanowski; Tobias Banaschewski; Alexis Barbot; Gareth J. Barker; Ruediger Bruehl; Christian Buechel; Katrin Charlet; Patricia J. Conrod; Katharina Czech; Jeff W. Dalley; Herta Flor; Ines Haeke; Bernd Ittermann; Nikolay Ivanov; Karl Mann; Katharina Luedemann; Jean-Luc Martinot; Carla Palafox; Tomas Paus; Jean-Baptiste Poline; Jan Reuter; Marcella Rietschel; Trevor W. Robbins; Michael N. Smolka; Andreas Stroehle; Bernadeta Walaszek; Norbert Kathmann; Gunter Schumann; Andreas Heinz; Hugh Garavan; Juergen Gallinat; IMAGEN Consortium

doi:10.1002/hbm.21446

Common structural correlates of trait impulsiveness and perceptual reasoning in adolescence

Christina Schilling, Simone Kuehn, Alexander Romanowski, Tobias Banaschewski, Alexis Barbot, Gareth J. Barker, Ruediger Bruehl, Christian Buechel, Katrin Charlet, Patricia J. Conrod, Katharina Czech, Jeff W. Dalley, Herta Flor, Ines Haeke, Bernd Ittermann, Nikolay Ivanov, Karl Mann, Katharina Luedemann, Jean-Luc Martinot, Carla PalafoxTomas Paus, Jean-Baptiste Poline, Jan Reuter, Marcella Rietschel, Trevor W. Robbins, Michael N. Smolka, Andreas Stroehle, Bernadeta Walaszek, Norbert Kathmann, Gunter Schumann, Andreas Heinz, Hugh Garavan, Juergen Gallinat, IMAGEN Consortium

Research output: Contribution to journal › Literature review › peer-review

41 Citations (Scopus)

Abstract

Background: Trait impulsiveness is a potential factor that predicts both substance use and certain psychiatric disorders. This study investigates whether there are common structural cerebral correlates of trait impulsiveness and cognitive functioning in a large sample of healthy adolescents from the IMAGEN project.

Methods: Clusters of gray matter (GM) volume associated with trait impulsiveness, Cloningers' revised temperament, and character inventory impulsiveness (TCI-R-I) were identified in a whole brain analysis using optimized voxel-based morphometry in 115 healthy 14-year-olds. The clusters were tested for correlations with performance on the nonverbal tests (Block Design, BD; Matrix Reasoning, MT) of the Wechsler Scale of Intelligence for Children IV reflecting perceptual reasoning.

Results: Cloningers' impulsiveness (TCI-R-I) score was significantly inversely associated with GM volume in left orbitofrontal cortex (OFC). Frontal clusters found were positively correlated with performance in perceptual reasoning tasks (Bonferroni corrected). No significant correlations between TCI-R-I and perceptual reasoning were observed.

Conclusions: The neural correlate of trait impulsiveness in the OFC matches an area where brain function has previously been related to inhibitory control. Additionally, orbitofrontal GM volume was associated with scores for perceptual reasoning. The data show for the first time structural correlates of both cognitive functioning and impulsiveness in healthy adolescent subjects. Hum Brain Mapp, 2013. (C) 2011 Wiley Periodicals, Inc.

Original language	English
Pages (from-to)	374-383
Number of pages	10
Journal	Human Brain Mapping
Volume	34
Issue number	2
DOIs	https://doi.org/10.1002/hbm.21446
Publication status	Published - Feb 2013

Access to Document

10.1002/hbm.21446

Cite this

Schilling, C., Kuehn, S., Romanowski, A., Banaschewski, T., Barbot, A., Barker, G. J., Bruehl, R., Buechel, C., Charlet, K., Conrod, P. J., Czech, K., Dalley, J. W., Flor, H., Haeke, I., Ittermann, B., Ivanov, N., Mann, K., Luedemann, K., Martinot, J.-L., ... IMAGEN Consortium (2013). Common structural correlates of trait impulsiveness and perceptual reasoning in adolescence. Human Brain Mapping, 34(2), 374-383. https://doi.org/10.1002/hbm.21446

@article{e939e0ea2eee4d0fac63188eb5bf42b7,

title = "Common structural correlates of trait impulsiveness and perceptual reasoning in adolescence",

abstract = "Background: Trait impulsiveness is a potential factor that predicts both substance use and certain psychiatric disorders. This study investigates whether there are common structural cerebral correlates of trait impulsiveness and cognitive functioning in a large sample of healthy adolescents from the IMAGEN project. Methods: Clusters of gray matter (GM) volume associated with trait impulsiveness, Cloningers' revised temperament, and character inventory impulsiveness (TCI-R-I) were identified in a whole brain analysis using optimized voxel-based morphometry in 115 healthy 14-year-olds. The clusters were tested for correlations with performance on the nonverbal tests (Block Design, BD; Matrix Reasoning, MT) of the Wechsler Scale of Intelligence for Children IV reflecting perceptual reasoning. Results: Cloningers' impulsiveness (TCI-R-I) score was significantly inversely associated with GM volume in left orbitofrontal cortex (OFC). Frontal clusters found were positively correlated with performance in perceptual reasoning tasks (Bonferroni corrected). No significant correlations between TCI-R-I and perceptual reasoning were observed. Conclusions: The neural correlate of trait impulsiveness in the OFC matches an area where brain function has previously been related to inhibitory control. Additionally, orbitofrontal GM volume was associated with scores for perceptual reasoning. The data show for the first time structural correlates of both cognitive functioning and impulsiveness in healthy adolescent subjects. Hum Brain Mapp, 2013. (C) 2011 Wiley Periodicals, Inc.",

author = "Christina Schilling and Simone Kuehn and Alexander Romanowski and Tobias Banaschewski and Alexis Barbot and Barker, {Gareth J.} and Ruediger Bruehl and Christian Buechel and Katrin Charlet and Conrod, {Patricia J.} and Katharina Czech and Dalley, {Jeff W.} and Herta Flor and Ines Haeke and Bernd Ittermann and Nikolay Ivanov and Karl Mann and Katharina Luedemann and Jean-Luc Martinot and Carla Palafox and Tomas Paus and Jean-Baptiste Poline and Jan Reuter and Marcella Rietschel and Robbins, {Trevor W.} and Smolka, {Michael N.} and Andreas Stroehle and Bernadeta Walaszek and Norbert Kathmann and Gunter Schumann and Andreas Heinz and Hugh Garavan and Juergen Gallinat and {IMAGEN Consortium}",

year = "2013",

month = feb,

doi = "10.1002/hbm.21446",

language = "English",

volume = "34",

pages = "374--383",

journal = "Human Brain Mapping",

issn = "1065-9471",

publisher = "Wiley-Liss Inc.",

number = "2",

}

Schilling, C, Kuehn, S, Romanowski, A, Banaschewski, T, Barbot, A, Barker, GJ, Bruehl, R, Buechel, C, Charlet, K, Conrod, PJ, Czech, K, Dalley, JW, Flor, H, Haeke, I, Ittermann, B, Ivanov, N, Mann, K, Luedemann, K, Martinot, J-L, Palafox, C, Paus, T, Poline, J-B, Reuter, J, Rietschel, M, Robbins, TW, Smolka, MN, Stroehle, A, Walaszek, B, Kathmann, N, Schumann, G, Heinz, A, Garavan, H, Gallinat, J & IMAGEN Consortium 2013, 'Common structural correlates of trait impulsiveness and perceptual reasoning in adolescence', Human Brain Mapping, vol. 34, no. 2, pp. 374-383. https://doi.org/10.1002/hbm.21446

TY - JOUR

T1 - Common structural correlates of trait impulsiveness and perceptual reasoning in adolescence

AU - Schilling, Christina

AU - Kuehn, Simone

AU - Romanowski, Alexander

AU - Banaschewski, Tobias

AU - Barbot, Alexis

AU - Barker, Gareth J.

AU - Bruehl, Ruediger

AU - Buechel, Christian

AU - Charlet, Katrin

AU - Conrod, Patricia J.

AU - Czech, Katharina

AU - Dalley, Jeff W.

AU - Flor, Herta

AU - Haeke, Ines

AU - Ittermann, Bernd

AU - Ivanov, Nikolay

AU - Mann, Karl

AU - Luedemann, Katharina

AU - Martinot, Jean-Luc

AU - Palafox, Carla

AU - Paus, Tomas

AU - Poline, Jean-Baptiste

AU - Reuter, Jan

AU - Rietschel, Marcella

AU - Robbins, Trevor W.

AU - Smolka, Michael N.

AU - Stroehle, Andreas

AU - Walaszek, Bernadeta

AU - Kathmann, Norbert

AU - Schumann, Gunter

AU - Heinz, Andreas

AU - Garavan, Hugh

AU - Gallinat, Juergen

AU - IMAGEN Consortium

PY - 2013/2

Y1 - 2013/2

N2 - Background: Trait impulsiveness is a potential factor that predicts both substance use and certain psychiatric disorders. This study investigates whether there are common structural cerebral correlates of trait impulsiveness and cognitive functioning in a large sample of healthy adolescents from the IMAGEN project. Methods: Clusters of gray matter (GM) volume associated with trait impulsiveness, Cloningers' revised temperament, and character inventory impulsiveness (TCI-R-I) were identified in a whole brain analysis using optimized voxel-based morphometry in 115 healthy 14-year-olds. The clusters were tested for correlations with performance on the nonverbal tests (Block Design, BD; Matrix Reasoning, MT) of the Wechsler Scale of Intelligence for Children IV reflecting perceptual reasoning. Results: Cloningers' impulsiveness (TCI-R-I) score was significantly inversely associated with GM volume in left orbitofrontal cortex (OFC). Frontal clusters found were positively correlated with performance in perceptual reasoning tasks (Bonferroni corrected). No significant correlations between TCI-R-I and perceptual reasoning were observed. Conclusions: The neural correlate of trait impulsiveness in the OFC matches an area where brain function has previously been related to inhibitory control. Additionally, orbitofrontal GM volume was associated with scores for perceptual reasoning. The data show for the first time structural correlates of both cognitive functioning and impulsiveness in healthy adolescent subjects. Hum Brain Mapp, 2013. (C) 2011 Wiley Periodicals, Inc.

AB - Background: Trait impulsiveness is a potential factor that predicts both substance use and certain psychiatric disorders. This study investigates whether there are common structural cerebral correlates of trait impulsiveness and cognitive functioning in a large sample of healthy adolescents from the IMAGEN project. Methods: Clusters of gray matter (GM) volume associated with trait impulsiveness, Cloningers' revised temperament, and character inventory impulsiveness (TCI-R-I) were identified in a whole brain analysis using optimized voxel-based morphometry in 115 healthy 14-year-olds. The clusters were tested for correlations with performance on the nonverbal tests (Block Design, BD; Matrix Reasoning, MT) of the Wechsler Scale of Intelligence for Children IV reflecting perceptual reasoning. Results: Cloningers' impulsiveness (TCI-R-I) score was significantly inversely associated with GM volume in left orbitofrontal cortex (OFC). Frontal clusters found were positively correlated with performance in perceptual reasoning tasks (Bonferroni corrected). No significant correlations between TCI-R-I and perceptual reasoning were observed. Conclusions: The neural correlate of trait impulsiveness in the OFC matches an area where brain function has previously been related to inhibitory control. Additionally, orbitofrontal GM volume was associated with scores for perceptual reasoning. The data show for the first time structural correlates of both cognitive functioning and impulsiveness in healthy adolescent subjects. Hum Brain Mapp, 2013. (C) 2011 Wiley Periodicals, Inc.

U2 - 10.1002/hbm.21446

DO - 10.1002/hbm.21446

M3 - Literature review

SN - 1065-9471

VL - 34

SP - 374

EP - 383

JO - Human Brain Mapping

JF - Human Brain Mapping

IS - 2

ER -

Common structural correlates of trait impulsiveness and perceptual reasoning in adolescence

Abstract

Access to Document

Fingerprint

Cite this