Common variants near TERC are associated with mean telomere length

Veryan Codd; Massimo Mangino; Pim van der Harst; Peter S. Braund; Michael Kaiser; Alan J. Beveridge; Suzanne Rafelt; Jasbir Moore; Chris Nelson; Nicole Soranzo; Guangju Zhai; Ana M. Valdes; Hannah Blackburn; Irene Mateo Leach; Rudolf A. de Boer; Alison H. Goodall; Willem Ouwehand; Dirk J. van Veldhuisen; Wiek H. van Gilst; Gerjan Navis; Paul R. Burton; Martin D. Tobin; Alistair S. Hall; John R. Thompson; Tim Spector; Nilesh J. Samani

doi:10.1038/ng.532

Common variants near TERC are associated with mean telomere length

Veryan Codd
, Massimo Mangino
, Pim van der Harst
, Peter S. Braund
, Michael Kaiser
, Alan J. Beveridge
, Suzanne Rafelt
, Jasbir Moore
, Chris Nelson
, Nicole Soranzo
, Guangju Zhai
, Ana M. Valdes
, Hannah Blackburn
, Irene Mateo Leach
, Rudolf A. de Boer
, Alison H. Goodall
, Willem Ouwehand
, Dirk J. van Veldhuisen
, Wiek H. van Gilst
, Gerjan Navis

Paul R. Burton, Martin D. Tobin, Alistair S. Hall, John R. Thompson, Tim Spector, Nilesh J. Samani

Research output: Contribution to journal › Article › peer-review

298 Citations (Scopus)

Abstract

We conducted genome-wide association analyses of mean leukocyte telomere length in 2,917 individuals, with follow-up replication in 9,492 individuals. We identified an association with telomere length on 3q26 (rs12696304, combined P = 3.72 x 10(-14)) at a locus that includes TERC, which encodes the telomerase RNA component. Each copy of the minor allele of rs12696304 was associated with an similar to 75-base-pair reduction in mean telomere length, equivalent to similar to 3.6 years of age-related telomere-length attrition.

Original language	English
Pages (from-to)	197 - 199
Number of pages	3
Journal	Nature Genetics
Volume	42
Issue number	3
DOIs	https://doi.org/10.1038/ng.532
Publication status	Published - Mar 2010

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Codd, V., Mangino, M., van der Harst, P., Braund, P. S., Kaiser, M., Beveridge, A. J., Rafelt, S., Moore, J., Nelson, C., Soranzo, N., Zhai, G., Valdes, A. M., Blackburn, H., Leach, I. M., de Boer, R. A., Goodall, A. H., Ouwehand, W., van Veldhuisen, D. J., van Gilst, W. H., ... Samani, N. J. (2010). Common variants near TERC are associated with mean telomere length. Nature Genetics, 42(3), 197 - 199. https://doi.org/10.1038/ng.532

@article{cae915bb4edc400a995d4711df1634f5,

title = "Common variants near TERC are associated with mean telomere length",

abstract = "We conducted genome-wide association analyses of mean leukocyte telomere length in 2,917 individuals, with follow-up replication in 9,492 individuals. We identified an association with telomere length on 3q26 (rs12696304, combined P = 3.72 x 10(-14)) at a locus that includes TERC, which encodes the telomerase RNA component. Each copy of the minor allele of rs12696304 was associated with an similar to 75-base-pair reduction in mean telomere length, equivalent to similar to 3.6 years of age-related telomere-length attrition.",

author = "Veryan Codd and Massimo Mangino and \{van der Harst\}, Pim and Braund, \{Peter S.\} and Michael Kaiser and Beveridge, \{Alan J.\} and Suzanne Rafelt and Jasbir Moore and Chris Nelson and Nicole Soranzo and Guangju Zhai and Valdes, \{Ana M.\} and Hannah Blackburn and Leach, \{Irene Mateo\} and \{de Boer\}, \{Rudolf A.\} and Goodall, \{Alison H.\} and Willem Ouwehand and \{van Veldhuisen\}, \{Dirk J.\} and \{van Gilst\}, \{Wiek H.\} and Gerjan Navis and Burton, \{Paul R.\} and Tobin, \{Martin D.\} and Hall, \{Alistair S.\} and Thompson, \{John R.\} and Tim Spector and Samani, \{Nilesh J.\}",

year = "2010",

month = mar,

doi = "10.1038/ng.532",

language = "English",

volume = "42",

pages = "197 -- 199",

journal = "Nature Genetics",

issn = "1546-1718",

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number = "3",

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Codd, V, Mangino, M, van der Harst, P, Braund, PS, Kaiser, M, Beveridge, AJ, Rafelt, S, Moore, J, Nelson, C, Soranzo, N, Zhai, G , Valdes, AM, Blackburn, H, Leach, IM, de Boer, RA, Goodall, AH, Ouwehand, W, van Veldhuisen, DJ, van Gilst, WH, Navis, G, Burton, PR, Tobin, MD, Hall, AS, Thompson, JR, Spector, T & Samani, NJ 2010, 'Common variants near TERC are associated with mean telomere length', Nature Genetics, vol. 42, no. 3, pp. 197 - 199. https://doi.org/10.1038/ng.532

TY - JOUR

T1 - Common variants near TERC are associated with mean telomere length

AU - Codd, Veryan

AU - Mangino, Massimo

AU - van der Harst, Pim

AU - Braund, Peter S.

AU - Kaiser, Michael

AU - Beveridge, Alan J.

AU - Rafelt, Suzanne

AU - Moore, Jasbir

AU - Nelson, Chris

AU - Soranzo, Nicole

AU - Zhai, Guangju

AU - Valdes, Ana M.

AU - Blackburn, Hannah

AU - Leach, Irene Mateo

AU - de Boer, Rudolf A.

AU - Goodall, Alison H.

AU - Ouwehand, Willem

AU - van Veldhuisen, Dirk J.

AU - van Gilst, Wiek H.

AU - Navis, Gerjan

AU - Burton, Paul R.

AU - Tobin, Martin D.

AU - Hall, Alistair S.

AU - Thompson, John R.

AU - Spector, Tim

AU - Samani, Nilesh J.

PY - 2010/3

Y1 - 2010/3

N2 - We conducted genome-wide association analyses of mean leukocyte telomere length in 2,917 individuals, with follow-up replication in 9,492 individuals. We identified an association with telomere length on 3q26 (rs12696304, combined P = 3.72 x 10(-14)) at a locus that includes TERC, which encodes the telomerase RNA component. Each copy of the minor allele of rs12696304 was associated with an similar to 75-base-pair reduction in mean telomere length, equivalent to similar to 3.6 years of age-related telomere-length attrition.

AB - We conducted genome-wide association analyses of mean leukocyte telomere length in 2,917 individuals, with follow-up replication in 9,492 individuals. We identified an association with telomere length on 3q26 (rs12696304, combined P = 3.72 x 10(-14)) at a locus that includes TERC, which encodes the telomerase RNA component. Each copy of the minor allele of rs12696304 was associated with an similar to 75-base-pair reduction in mean telomere length, equivalent to similar to 3.6 years of age-related telomere-length attrition.

U2 - 10.1038/ng.532

DO - 10.1038/ng.532

M3 - Article

SN - 1546-1718

VL - 42

SP - 197

EP - 199

JO - Nature Genetics

JF - Nature Genetics

IS - 3

ER -

Common variants near TERC are associated with mean telomere length

Abstract

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