Comorbid depression in medical diseases

Stefan M Gold; Ole Kohler-Forsberg; Rona Moss-Morris; Anja Mehnert; J. Jaime Miranda; Monika Bullinger; Andrew Steptoe; Mary A. Whooley; Christian Otte

doi:10.1038/s41572-020-0200-2

Comorbid depression in medical diseases

Stefan M Gold, Ole Kohler-Forsberg, Rona Moss-Morris, Anja Mehnert, J. Jaime Miranda, Monika Bullinger, Andrew Steptoe, Mary A. Whooley, Christian Otte

Research output: Contribution to journal › Review article › peer-review

333 Citations (Scopus)

Abstract

Depression is one of the most common comorbidities of many chronic medical diseases including cancer and cardiovascular, metabolic, inflammatory and neurological disorders. Indeed, the prevalence of depression in these patient groups is often substantially higher than in the general population, and depression accounts for a substantial part of the psychosocial burden of these disorders. Many factors can contribute to the occurrence of comorbid depression, such as shared genetic factors, converging biological pathways, social factors, health behaviours and psychological factors. Diagnosis of depression in patients with a medical disorder can be particularly challenging owing to symptomatic overlap. Although pharmacological and psychological treatments can be effective, adjustments may need to be made for patients with a comorbid medical disorder. In addition, symptoms or treatments of medical disorders may interfere with the treatment of depression. Conversely, symptoms of depression may decrease adherence to treatment of both disorders. Thus, comprehensive treatment plans are necessary to optimize care.

Original language	English
Article number	69
Pages (from-to)	1
Number of pages	22
Journal	Nature Review Disease Primers
Volume	6
Issue number	1
DOIs	https://doi.org/10.1038/s41572-020-0200-2
Publication status	Published - 20 Aug 2020

Keywords

Comorbid depression
chronic medical diseases
MDD

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/s41572-020-0200-2

Cite this

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AU - Moss-Morris, Rona

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AU - Bullinger, Monika

AU - Steptoe, Andrew

AU - Whooley, Mary A.

AU - Otte, Christian

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Comorbid depression in medical diseases

Abstract

Keywords

UN SDGs

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