Comparative assessment of small intestinal and colonic permeability in HIV-infected homosexual men.

TY - JOUR

T1 - Comparative assessment of small intestinal and colonic permeability in HIV-infected homosexual men.

AU - Obinna, F.

AU - Cook, Gary

AU - Beale, Timothy

AU - Dave, S

AU - Cunningham, D

AU - Fleming, S

AU - Claydon, E.

AU - Harris, J

AU - Kapembwa, M.

PY - 1995

Y1 - 1995

N2 - AB Objectives: To investigate both small and large intestinal permeability in HIV-positive subjects, and correlate variation in intestinal mucosal abnormality with immunological and nutritional markers of HIV disease. Methods: Small and large intestinal permeability studies were performed in 14 HIV-seropositive patients and eight healthy men. Eight out of the 14 patients had diarrhoea and all subjects were negative for enteropathogens. Small intestinal permeability was determined using the lactulose-mannitol test and large intestinal permeability using the colonic absorption of 51Cr-EDTA. In addition, CD4 cell count, [beta]2-microglobulin, C-reactive protein estimation and anthropometry were carried out in all subjects. Results: HIV-seropositive subjects had higher lactulose-mannitol ratios (LMR; 0.084+/-0.007 versus 0.013+/-0.0008) and lower 51Cr activity (1.986+/-0.066 versus 3.115+/-0.560) than controls (P<0.0004 and P<0.05, respectively). Colonic uptake of 51Cr-EDTA was no different between subjects with and those without diarrhoea (2.04+/-0.124 versus 1.92+/-0.143; P> 0.05). A negative correlation was found between LMR and 51Cr-EDTA, but only for patients with diarrhoea (r=-0.81; P=0.015). Conclusion: Regional variation affecting intestinal absorptive function occurs in patients with HIV-related diarrhoea and is characterized by increased LMR and reduced colonic uptake of 51Cr-EDTA. The pathogenesis and clinical significance of such changes are unknown

AB - AB Objectives: To investigate both small and large intestinal permeability in HIV-positive subjects, and correlate variation in intestinal mucosal abnormality with immunological and nutritional markers of HIV disease. Methods: Small and large intestinal permeability studies were performed in 14 HIV-seropositive patients and eight healthy men. Eight out of the 14 patients had diarrhoea and all subjects were negative for enteropathogens. Small intestinal permeability was determined using the lactulose-mannitol test and large intestinal permeability using the colonic absorption of 51Cr-EDTA. In addition, CD4 cell count, [beta]2-microglobulin, C-reactive protein estimation and anthropometry were carried out in all subjects. Results: HIV-seropositive subjects had higher lactulose-mannitol ratios (LMR; 0.084+/-0.007 versus 0.013+/-0.0008) and lower 51Cr activity (1.986+/-0.066 versus 3.115+/-0.560) than controls (P<0.0004 and P<0.05, respectively). Colonic uptake of 51Cr-EDTA was no different between subjects with and those without diarrhoea (2.04+/-0.124 versus 1.92+/-0.143; P> 0.05). A negative correlation was found between LMR and 51Cr-EDTA, but only for patients with diarrhoea (r=-0.81; P=0.015). Conclusion: Regional variation affecting intestinal absorptive function occurs in patients with HIV-related diarrhoea and is characterized by increased LMR and reduced colonic uptake of 51Cr-EDTA. The pathogenesis and clinical significance of such changes are unknown

M3 - Article

SN - 0269-9370

VL - 9

SP - 1009

EP - 1016

JO - Aids

JF - Aids

IS - 9

ER -