@article{638df90a8c11417dbaddb2cdb08c0168,
title = "Comparative efficacy of omega-3 polyunsaturated fatty acids on major cardiovascular events: A network meta-analysis of randomized controlled trials",
abstract = "The role of omega-3 polyunsaturated fatty acids (PUFAs) in primary and secondary prevention on major cardiovascular events (MCE) is inconclusive due to the potential heterogeneity in study designs of formulas, dosages, and ratios of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) from the findings of previous randomized controlled trials (RCTs). Here we conducted a comprehensive narrative review of pre-clinical studies and updated a network meta-analysis (NMA) to determine the comparative efficacy against MCE with different EPA/DHA dosages and formulas. We found that pure EPA was ranked the best option in the secondary prevention (hazard ratio: 0.72, 95% confidence interval: 0.65 to 0.81) from the NMA of 39 RCTs with 88,359 participants. There was no evidence of omega-3 PUFAs' efficacy in primary prevention. The mechanisms of omega-3 PUFAs' cardiovascular protection might link to the effects of anti-inflammation and stabilization of endothelial function from PUFA's derivatives including eicosanoids and the special pre-resolving mediators (SPMs).",
keywords = "Cardiovascular disease, Major cardiovascular events, Network meta-analysis, Omega-3",
author = "Bo Yang and Tseng, {Ping Tao} and Xiang Hu and Zeng, {Bing Yan} and Chang, {Jane Pei Chen} and Yang Liu and Chu, {Wei Jie} and Zhang, {Shuang Shuang} and Zhou, {Zhi Liang} and Chu, {Chih Sheng} and Chang, {Cheng Ho} and Tu, {Yu Kang} and Wu, {Yi Cheng} and Brendon Stubbs and Carvalho, {Andre F.} and Lin, {Pao Yen} and Matsuoka, {Yutaka J.} and Suen, {Mein Woei} and Su, {Kuan Pin}",
note = "Funding Information: The authors of the work is supported by the following grants: MOST 109–2320-B-038-057-MY3, 109–2320-B-039-066, 110–2321-B-006-004, 110–2811-B-039-507, 110–2320-B-039-048-MY2, 110–2320-B-039-047-MY3, 110–2813-C-039-327-B, 110–2314-B-039-029-MY3, 111–2321-B-006-008, and 111–2314-B-039-041-MY3 from the Ministry of Science and Technology, Taiwan ; ANHRF 109–31, 109–40, 110–13, 110–26, 110–44, 110–45, 111–27, 111–28, 111–47, 111–48, and 111–52 from An-Nan Hospital, China Medical University , Tainan, Taiwan; CMRC-CMA-2 from Higher Education Sprout Project by the Ministry of Education (MOE), Taiwan; CMU 110-AWARD-02, CMU108-SR-106 from the China Medical University , Taichung, Taiwan; and CRS-108-048, DMR-102-076, DMR-103-084, DMR-106-225, DMR-107-204, DMR-108-216, DMR-109-102, DMR-109-244, DMR-HHC-109-11, DMR-HHC-109-12, DMR-HHC-110-10, and DMR-110-124 from the China Medical University Hospital , Taichung, Taiwan. Brendon Stubbs is supported by a clinical lectureship (ICA-CL-2017-03-001) jointly funded by Health Education England (HEE) and the National Institute for Health Research (NIHR). Stubbs is partially funded by the NIHR Biomedical Research Centre at South London and the Maudsley NHS Foundation Trust, the Maudsley Charity, King's College London and the NIHR South London Collaboration for Leadership in Applied Health Research and Care (CLAHRC) funding. Yutaka Matsuoka is supported by a Grant-in-Aid for Scientific Research B from the Japan Society for the Promotion of Science (No. 17H04253), a Health Labour Sciences Research Grant from the Japanese Ministry of Health, Labour and Welfare (H30-Cancer Policy-General-005), the National Cancer Center Research and Development Fund (30-A-17), and a grant from the SENSHIN Medical Research Foundation. Bo Yang was supported by the PhD Programs Foundation of Wenzhou Medical University , China (No. 89217015) and the 2017 Chinese Nutrition Society (CNS) Nutrition Research Foundation—DSM Research Fund (No. 2017–008). Publisher Copyright: {\textcopyright} 2022 Elsevier Ltd",
year = "2022",
month = nov,
doi = "10.1016/j.plipres.2022.101196",
language = "English",
volume = "88",
journal = "Progress in Lipid Research",
issn = "0163-7827",
publisher = "Elsevier Limited",
}
