Comparative efficacy testing - fractional flow reserve by coronary computed tomography for the evaluation of patients with stable chest pain

TY - JOUR

T1 - Comparative efficacy testing - fractional flow reserve by coronary computed tomography for the evaluation of patients with stable chest pain

AU - Rajani, Ronak

AU - Webb, Jessica

AU - Marciniak, Anna

AU - Preston, Rebecca

PY - 2015/3/15

Y1 - 2015/3/15

N2 - Background To evaluate diagnostic strategies in a rapid access chest pain clinic (RACPC) in the United Kingdom and to predict the economical and clinical impacts of incorporating fractional flow reserve by coronary computed tomographic angiography (FFRCT) into future pathways. Methods A retrospective analysis of consecutive patients referred to a RACPC in the United Kingdom. All patients had an evaluation of cardiovascular risk factors and symptoms from which the pre-test likelihood (PTL) of coronary artery disease (CAD) was evaluated using the Diamond Forrester (DF) criteria. All investigative strategies and their results were recorded. For the FFRCT economic evaluation of 1000 patients, standard National Health Service Tariffs were then applied and compared with a strategy that utilised FFRCT for varying PTL categories. Results There were 410 patients with a median age of 57 (31–85) years. The DF criteria classified 39 (9.5%) patients as having a PTL of < 10%, 76 (18.5%) 10–29% PTL, 117 (28.5%) 30–60% PTL, 114 (27.8%) 60–90% PTL and 64 (15.6%) > 90% PTL. The concordance with the NICE recommended guidelines was < 50% with the prevalence of obstructive CAD being < 5% in patients with a PTL < 90%. A model utilising FFRCT for patients with a PTL 10–90% predicted a 48% and 49% reduction in invasive angiography and percutaneous coronary intervention, a saving of £200 per patient and a reduction in relative adverse event rates of 4%. Conclusions The DF algorithm overestimates the PTL of CAD supporting an extended role for coronary CTA. Strategies incorporating FFRCT may confer benefits in evaluating patients with stable chest pain.

AB - Background To evaluate diagnostic strategies in a rapid access chest pain clinic (RACPC) in the United Kingdom and to predict the economical and clinical impacts of incorporating fractional flow reserve by coronary computed tomographic angiography (FFRCT) into future pathways. Methods A retrospective analysis of consecutive patients referred to a RACPC in the United Kingdom. All patients had an evaluation of cardiovascular risk factors and symptoms from which the pre-test likelihood (PTL) of coronary artery disease (CAD) was evaluated using the Diamond Forrester (DF) criteria. All investigative strategies and their results were recorded. For the FFRCT economic evaluation of 1000 patients, standard National Health Service Tariffs were then applied and compared with a strategy that utilised FFRCT for varying PTL categories. Results There were 410 patients with a median age of 57 (31–85) years. The DF criteria classified 39 (9.5%) patients as having a PTL of < 10%, 76 (18.5%) 10–29% PTL, 117 (28.5%) 30–60% PTL, 114 (27.8%) 60–90% PTL and 64 (15.6%) > 90% PTL. The concordance with the NICE recommended guidelines was < 50% with the prevalence of obstructive CAD being < 5% in patients with a PTL < 90%. A model utilising FFRCT for patients with a PTL 10–90% predicted a 48% and 49% reduction in invasive angiography and percutaneous coronary intervention, a saving of £200 per patient and a reduction in relative adverse event rates of 4%. Conclusions The DF algorithm overestimates the PTL of CAD supporting an extended role for coronary CTA. Strategies incorporating FFRCT may confer benefits in evaluating patients with stable chest pain.

U2 - 10.1016/j.ijcard.2015.01.035

DO - 10.1016/j.ijcard.2015.01.035

M3 - Article

SN - 0167-5273

VL - 183

SP - 173

EP - 177

JO - International Journal of Cardiology

JF - International Journal of Cardiology

ER -