Comparing the test–retest reliability of resting-state functional magnetic resonance imaging metrics across single band and multiband acquisitions in the context of healthy aging

TY - JOUR

T1 - Comparing the test–retest reliability of resting-state functional magnetic resonance imaging metrics across single band and multiband acquisitions in the context of healthy aging

AU - Cahart, Marie Stephanie

AU - O'Daly, Owen

AU - Giampietro, Vincent

AU - Timmers, Maarten

AU - Streffer, Johannes

AU - Einstein, Steven

AU - Zelaya, Fernando

AU - Dell'Acqua, Flavio

AU - Williams, Steven C.R.

N1 - Funding Information: We would like to thank all the participants who took part in this study, as well as Janssen Research and Development, a division of Janssen Pharmaceutica N.V., the Wellcome Trust/EPSRC Centre for Medical Engineering, the Experimental Medicine Challenge Grant and the National Institute for Health Research (NIHR) Maudsley Biomedical Research Centre and Clinical Research Facility at South London and Maudsley NHS Foundation Trust and King's College London, for their funding and ongoing support of our neuroimaging endeavors. Funding Information: Janssen Research and Development, Grant/Award Number: NOPRODNAP0009; Medical Research Council, Grant/Award Number: MR/N026969/1; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research, Grant/Award Number: IS‐BRC‐1215‐20018; Wellcome Trust/EPSRC Centre for Medical Engineering, Grant/Award Number: WT 203148/Z/16/Z; Janssen Pharmaceutica N.V.; Clinical Research Facility; Maudsley NHS Foundation Trust; King's College London Funding information Publisher Copyright: © 2022 The Authors. Human Brain Mapping published by Wiley Periodicals LLC.

PY - 2023/4/1

Y1 - 2023/4/1

N2 - The identification of meaningful functional magnetic resonance imaging (fMRI) biomarkers requires measures that reliably capture brain performance across different subjects and over multiple scanning sessions. Recent developments in fMRI acquisition, such as the introduction of multiband (MB) protocols and in-plane acceleration, allow for increased scanning speed and improved temporal resolution. However, they may also lead to reduced temporal signal to noise ratio and increased signal leakage between simultaneously excited slices. These methods have been adopted in several scanning modalities including diffusion weighted imaging and fMRI. To our knowledge, no study has formally compared the reliability of the same resting-state fMRI (rs-fMRI) metrics (amplitude of low-frequency fluctuations; seed-to-voxel and region of interest [ROI]-to-ROI connectivity) across conventional single-band fMRI and different MB acquisitions, with and without in-plane acceleration, across three sessions. In this study, 24 healthy older adults were scanned over three visits, on weeks 0, 1, and 4, and, on each occasion, underwent a conventional single band rs-fMRI scan and three different rs-fMRI scans with MB factors 4 and 6, with and without in-plane acceleration. Across all three rs-fMRI metrics, the reliability scores were highest with MB factor 4 with no in-plane acceleration for cortical areas and with conventional single band for subcortical areas. Recommendations for future research studies are discussed.

AB - The identification of meaningful functional magnetic resonance imaging (fMRI) biomarkers requires measures that reliably capture brain performance across different subjects and over multiple scanning sessions. Recent developments in fMRI acquisition, such as the introduction of multiband (MB) protocols and in-plane acceleration, allow for increased scanning speed and improved temporal resolution. However, they may also lead to reduced temporal signal to noise ratio and increased signal leakage between simultaneously excited slices. These methods have been adopted in several scanning modalities including diffusion weighted imaging and fMRI. To our knowledge, no study has formally compared the reliability of the same resting-state fMRI (rs-fMRI) metrics (amplitude of low-frequency fluctuations; seed-to-voxel and region of interest [ROI]-to-ROI connectivity) across conventional single-band fMRI and different MB acquisitions, with and without in-plane acceleration, across three sessions. In this study, 24 healthy older adults were scanned over three visits, on weeks 0, 1, and 4, and, on each occasion, underwent a conventional single band rs-fMRI scan and three different rs-fMRI scans with MB factors 4 and 6, with and without in-plane acceleration. Across all three rs-fMRI metrics, the reliability scores were highest with MB factor 4 with no in-plane acceleration for cortical areas and with conventional single band for subcortical areas. Recommendations for future research studies are discussed.

KW - connectivity

KW - fMRI

KW - multiband fMRI

KW - reliability

KW - resting-state

UR - http://www.scopus.com/inward/record.url?scp=85144945973&partnerID=8YFLogxK

U2 - 10.1002/hbm.26180

DO - 10.1002/hbm.26180

M3 - Article

AN - SCOPUS:85144945973

SN - 1065-9471

VL - 44

SP - 1901

EP - 1912

JO - Human Brain Mapping

JF - Human Brain Mapping

IS - 5

ER -