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Comparison of Interactions Between Control and Mutant Macrophages

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Original languageEnglish
Title of host publicationMedical Image Understanding and Analysis - 23rd Conference, MIUA 2019, Proceedings
Subtitle of host publicationommunications in Computer and Information Science
EditorsYalin Zheng, Bryan M. Williams, Ke Chen
PublisherSpringer, Cham
Pages470-477
Number of pages8
Volume 1065
ISBN (Electronic)978-3-030-39343-4
ISBN (Print)978-3-030-39342-7
DOIs
Publication statusPublished - 24 Jan 2020

Publication series

NameCommunications in Computer and Information Science
Volume1065 CCIS
ISSN (Print)1865-0929
ISSN (Electronic)1865-0937

Documents

King's Authors

Abstract

This paper presents a preliminary study on macrophages migration in Drosophila embryos, comparing two types of cells. The study is carried out by a framework called macrosight which analyses the movement and interaction of migrating macrophages. The framework incorporates a segmentation and tracking algorithm into analysing motion characteristics of cells after contact. In this particular study, the interactions between cells is characterised in the case of control embryos and Shot3 mutants, where the cells have been altered to suppress a specific protein, looking to understand what drives the movement. Statistical significance between control and mutant cells was found when comparing the direction of motion after contact in specific conditions. Such discoveries provide insights for future developments in combining biological experiments to computational analysis.

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