Comparison of linear versus inverse exponential methadone reduction curves in the detoxification of opiate addicts

J Strang; M Gossop

doi:10.1016/0306-4603(90)90054-2

Comparison of linear versus inverse exponential methadone reduction curves in the detoxification of opiate addicts

J Strang, M Gossop

Research output: Contribution to journal › Article › peer-review

39 Citations (Scopus)

Abstract

A linear methadone detoxification procedure is compared with an inverse exponential reduction curve in a double-blind study. The inverse exponential curve resulted in withdrawal symptomatology which was significantly greater during the acute phase of the opiate withdrawal curve and was not significantly different during the recovery phase. There was no difference between groups in the time course of the withdrawal syndrome, in peak symptom severity, nor in patient compliance. Separate analyses for high-dose and for low-dose addicts show variation in the suitability of the two curves according to dose. The implications for future research and treatment of the opiate withdrawal syndrome are discussed.

Original language	English
Pages (from-to)	541-7
Number of pages	7
Journal	Addictive Behaviors
Volume	15
Issue number	6
DOIs	https://doi.org/10.1016/0306-4603(90)90054-2
Publication status	Published - 1990

Keywords

Adult
Dose-Response Relationship, Drug
Double-Blind Method
Drug Administration Schedule
Female
Heroin Dependence
Hospitalization
Humans
Male
Methadone
Neurologic Examination
Substance Withdrawal Syndrome

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/0306-4603(90)90054-2

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title = "Comparison of linear versus inverse exponential methadone reduction curves in the detoxification of opiate addicts",

abstract = "A linear methadone detoxification procedure is compared with an inverse exponential reduction curve in a double-blind study. The inverse exponential curve resulted in withdrawal symptomatology which was significantly greater during the acute phase of the opiate withdrawal curve and was not significantly different during the recovery phase. There was no difference between groups in the time course of the withdrawal syndrome, in peak symptom severity, nor in patient compliance. Separate analyses for high-dose and for low-dose addicts show variation in the suitability of the two curves according to dose. The implications for future research and treatment of the opiate withdrawal syndrome are discussed.",

keywords = "Adult, Dose-Response Relationship, Drug, Double-Blind Method, Drug Administration Schedule, Female, Heroin Dependence, Hospitalization, Humans, Male, Methadone, Neurologic Examination, Substance Withdrawal Syndrome",

author = "J Strang and M Gossop",

year = "1990",

doi = "10.1016/0306-4603(90)90054-2",

language = "English",

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pages = "541--7",

journal = "Addictive Behaviors",

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T1 - Comparison of linear versus inverse exponential methadone reduction curves in the detoxification of opiate addicts

AU - Strang, J

AU - Gossop, M

PY - 1990

Y1 - 1990

N2 - A linear methadone detoxification procedure is compared with an inverse exponential reduction curve in a double-blind study. The inverse exponential curve resulted in withdrawal symptomatology which was significantly greater during the acute phase of the opiate withdrawal curve and was not significantly different during the recovery phase. There was no difference between groups in the time course of the withdrawal syndrome, in peak symptom severity, nor in patient compliance. Separate analyses for high-dose and for low-dose addicts show variation in the suitability of the two curves according to dose. The implications for future research and treatment of the opiate withdrawal syndrome are discussed.

AB - A linear methadone detoxification procedure is compared with an inverse exponential reduction curve in a double-blind study. The inverse exponential curve resulted in withdrawal symptomatology which was significantly greater during the acute phase of the opiate withdrawal curve and was not significantly different during the recovery phase. There was no difference between groups in the time course of the withdrawal syndrome, in peak symptom severity, nor in patient compliance. Separate analyses for high-dose and for low-dose addicts show variation in the suitability of the two curves according to dose. The implications for future research and treatment of the opiate withdrawal syndrome are discussed.

KW - Adult

KW - Dose-Response Relationship, Drug

KW - Double-Blind Method

KW - Drug Administration Schedule

KW - Female

KW - Heroin Dependence

KW - Hospitalization

KW - Humans

KW - Male

KW - Methadone

KW - Neurologic Examination

KW - Substance Withdrawal Syndrome

U2 - 10.1016/0306-4603(90)90054-2

DO - 10.1016/0306-4603(90)90054-2

M3 - Article

C2 - 2075851

SN - 0306-4603

VL - 15

SP - 541

EP - 547

JO - Addictive Behaviors

JF - Addictive Behaviors

IS - 6

ER -

Comparison of linear versus inverse exponential methadone reduction curves in the detoxification of opiate addicts

Abstract

Keywords

UN SDGs

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