Comparison of neural substrates of temporal discounting between youth with autism spectrum disorder and with obsessive-compulsive disorder

C O Carlisi; L Norman; C M Murphy; A Christakou; K Chantiluke; V Giampietro; A Simmons; M Brammer; D G Murphy; D Mataix-Cols; K Rubia; MRC AIMS consortium

doi:10.1017/S0033291717001088

Comparison of neural substrates of temporal discounting between youth with autism spectrum disorder and with obsessive-compulsive disorder

C O Carlisi^*, L Norman, C M Murphy, A Christakou, K Chantiluke, V Giampietro, A Simmons, M Brammer, D G Murphy, D Mataix-Cols, K Rubia, MRC AIMS consortium

^*Corresponding author for this work

University of Reading
From the Neurodegeneration Imaging Group (F.N., H.W., G.P., M.P.) and Department of Neuroimaging (M.A.M., E.A.R.), Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London; Imanova Ltd., Centre for Imaging Sciences (C.C., G.E.S., R.N.G., E.A.R.), and Division of Brain Sciences, Imperial College London (R.N.G), Hammersmith Hospital; and Sobell Department of Motor Neuroscience (T.F.), UCL Institute of Neurology, London, UK. [email protected].
Karolinska Institute
Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.

Research output: Contribution to journal › Article › peer-review

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Abstract

BACKGROUND: Autism spectrum disorder (ASD) and obsessive-compulsive disorder (OCD) share abnormalities in hot executive functions such as reward-based decision-making, as measured in the temporal discounting task (TD). No studies, however, have directly compared these disorders to investigate common/distinct neural profiles underlying such abnormalities. We wanted to test whether reward-based decision-making is a shared transdiagnostic feature of both disorders with similar neurofunctional substrates or whether it is a shared phenotype with disorder-differential neurofunctional underpinnings.

METHODS: Age and IQ-matched boys with ASD (N = 20), with OCD (N = 20) and 20 healthy controls, performed an individually-adjusted functional magnetic resonance imaging (fMRI) TD task. Brain activation and performance were compared between groups.

RESULTS: Boys with ASD showed greater choice-impulsivity than OCD and control boys. Whole-brain between-group comparison revealed shared reductions in ASD and OCD relative to control boys for delayed-immediate choices in right ventromedial/lateral orbitofrontal cortex extending into medial/inferior prefrontal cortex, and in cerebellum, posterior cingulate and precuneus. For immediate-delayed choices, patients relative to controls showed reduced activation in anterior cingulate/ventromedial prefrontal cortex reaching into left caudate, which, at a trend level, was more decreased in ASD than OCD patients, and in bilateral temporal and inferior parietal regions.

CONCLUSIONS: This first fMRI comparison between youth with ASD and with OCD, using a reward-based decision-making task, shows predominantly shared neurofunctional abnormalities during TD in key ventromedial, orbital- and inferior fronto-striatal, temporo-parietal and cerebellar regions of temporal foresight and reward processing, suggesting trans-diagnostic neurofunctional deficits.

Original language	English
Pages (from-to)	1-15
Number of pages	15
Journal	Psychological Medicine
Early online date	24 Apr 2017
DOIs	https://doi.org/10.1017/S0033291717001088
Publication status	E-pub ahead of print - 24 Apr 2017

Keywords

ASD
fMRI
OCD
temporal discounting

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Carlisi, C. O., Norman, L., Murphy, C. M., Christakou, A., Chantiluke, K., Giampietro, V., Simmons, A., Brammer, M., Murphy, D. G., Mataix-Cols, D., Rubia, K., & MRC AIMS consortium (2017). Comparison of neural substrates of temporal discounting between youth with autism spectrum disorder and with obsessive-compulsive disorder. Psychological Medicine, 1-15. Advance online publication. https://doi.org/10.1017/S0033291717001088

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title = "Comparison of neural substrates of temporal discounting between youth with autism spectrum disorder and with obsessive-compulsive disorder",

abstract = "BACKGROUND: Autism spectrum disorder (ASD) and obsessive-compulsive disorder (OCD) share abnormalities in hot executive functions such as reward-based decision-making, as measured in the temporal discounting task (TD). No studies, however, have directly compared these disorders to investigate common/distinct neural profiles underlying such abnormalities. We wanted to test whether reward-based decision-making is a shared transdiagnostic feature of both disorders with similar neurofunctional substrates or whether it is a shared phenotype with disorder-differential neurofunctional underpinnings.METHODS: Age and IQ-matched boys with ASD (N = 20), with OCD (N = 20) and 20 healthy controls, performed an individually-adjusted functional magnetic resonance imaging (fMRI) TD task. Brain activation and performance were compared between groups.RESULTS: Boys with ASD showed greater choice-impulsivity than OCD and control boys. Whole-brain between-group comparison revealed shared reductions in ASD and OCD relative to control boys for delayed-immediate choices in right ventromedial/lateral orbitofrontal cortex extending into medial/inferior prefrontal cortex, and in cerebellum, posterior cingulate and precuneus. For immediate-delayed choices, patients relative to controls showed reduced activation in anterior cingulate/ventromedial prefrontal cortex reaching into left caudate, which, at a trend level, was more decreased in ASD than OCD patients, and in bilateral temporal and inferior parietal regions.CONCLUSIONS: This first fMRI comparison between youth with ASD and with OCD, using a reward-based decision-making task, shows predominantly shared neurofunctional abnormalities during TD in key ventromedial, orbital- and inferior fronto-striatal, temporo-parietal and cerebellar regions of temporal foresight and reward processing, suggesting trans-diagnostic neurofunctional deficits.",

keywords = "ASD, fMRI, OCD, temporal discounting",

author = "Carlisi, {C O} and L Norman and Murphy, {C M} and A Christakou and K Chantiluke and V Giampietro and A Simmons and M Brammer and Murphy, {D G} and D Mataix-Cols and K Rubia and {MRC AIMS consortium}",

year = "2017",

month = apr,

day = "24",

doi = "10.1017/S0033291717001088",

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Carlisi, CO , Norman, L , Murphy, CM, Christakou, A, Chantiluke, K , Giampietro, V , Simmons, A , Brammer, M , Murphy, DG, Mataix-Cols, D, Rubia, K & MRC AIMS consortium 2017, 'Comparison of neural substrates of temporal discounting between youth with autism spectrum disorder and with obsessive-compulsive disorder', Psychological Medicine, pp. 1-15. https://doi.org/10.1017/S0033291717001088

TY - JOUR

T1 - Comparison of neural substrates of temporal discounting between youth with autism spectrum disorder and with obsessive-compulsive disorder

AU - Carlisi, C O

AU - Norman, L

AU - Murphy, C M

AU - Christakou, A

AU - Chantiluke, K

AU - Giampietro, V

AU - Simmons, A

AU - Brammer, M

AU - Murphy, D G

AU - Mataix-Cols, D

AU - Rubia, K

AU - MRC AIMS consortium

PY - 2017/4/24

Y1 - 2017/4/24

N2 - BACKGROUND: Autism spectrum disorder (ASD) and obsessive-compulsive disorder (OCD) share abnormalities in hot executive functions such as reward-based decision-making, as measured in the temporal discounting task (TD). No studies, however, have directly compared these disorders to investigate common/distinct neural profiles underlying such abnormalities. We wanted to test whether reward-based decision-making is a shared transdiagnostic feature of both disorders with similar neurofunctional substrates or whether it is a shared phenotype with disorder-differential neurofunctional underpinnings.METHODS: Age and IQ-matched boys with ASD (N = 20), with OCD (N = 20) and 20 healthy controls, performed an individually-adjusted functional magnetic resonance imaging (fMRI) TD task. Brain activation and performance were compared between groups.RESULTS: Boys with ASD showed greater choice-impulsivity than OCD and control boys. Whole-brain between-group comparison revealed shared reductions in ASD and OCD relative to control boys for delayed-immediate choices in right ventromedial/lateral orbitofrontal cortex extending into medial/inferior prefrontal cortex, and in cerebellum, posterior cingulate and precuneus. For immediate-delayed choices, patients relative to controls showed reduced activation in anterior cingulate/ventromedial prefrontal cortex reaching into left caudate, which, at a trend level, was more decreased in ASD than OCD patients, and in bilateral temporal and inferior parietal regions.CONCLUSIONS: This first fMRI comparison between youth with ASD and with OCD, using a reward-based decision-making task, shows predominantly shared neurofunctional abnormalities during TD in key ventromedial, orbital- and inferior fronto-striatal, temporo-parietal and cerebellar regions of temporal foresight and reward processing, suggesting trans-diagnostic neurofunctional deficits.

AB - BACKGROUND: Autism spectrum disorder (ASD) and obsessive-compulsive disorder (OCD) share abnormalities in hot executive functions such as reward-based decision-making, as measured in the temporal discounting task (TD). No studies, however, have directly compared these disorders to investigate common/distinct neural profiles underlying such abnormalities. We wanted to test whether reward-based decision-making is a shared transdiagnostic feature of both disorders with similar neurofunctional substrates or whether it is a shared phenotype with disorder-differential neurofunctional underpinnings.METHODS: Age and IQ-matched boys with ASD (N = 20), with OCD (N = 20) and 20 healthy controls, performed an individually-adjusted functional magnetic resonance imaging (fMRI) TD task. Brain activation and performance were compared between groups.RESULTS: Boys with ASD showed greater choice-impulsivity than OCD and control boys. Whole-brain between-group comparison revealed shared reductions in ASD and OCD relative to control boys for delayed-immediate choices in right ventromedial/lateral orbitofrontal cortex extending into medial/inferior prefrontal cortex, and in cerebellum, posterior cingulate and precuneus. For immediate-delayed choices, patients relative to controls showed reduced activation in anterior cingulate/ventromedial prefrontal cortex reaching into left caudate, which, at a trend level, was more decreased in ASD than OCD patients, and in bilateral temporal and inferior parietal regions.CONCLUSIONS: This first fMRI comparison between youth with ASD and with OCD, using a reward-based decision-making task, shows predominantly shared neurofunctional abnormalities during TD in key ventromedial, orbital- and inferior fronto-striatal, temporo-parietal and cerebellar regions of temporal foresight and reward processing, suggesting trans-diagnostic neurofunctional deficits.

KW - ASD

KW - fMRI

KW - OCD

KW - temporal discounting

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DO - 10.1017/S0033291717001088

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JO - Psychological Medicine

JF - Psychological Medicine

ER -

Comparison of neural substrates of temporal discounting between youth with autism spectrum disorder and with obsessive-compulsive disorder

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Keywords

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