Comparison of reversed-phase and hydrophilic interaction liquid chromatography for the separation of ephedrines

James Heaton; Nicola Gray; David A. Cowan; Robert S. Plumb; Cristina Legido-Quigley; Norman W. Smith

doi:10.1016/j.chroma.2011.09.026

Comparison of reversed-phase and hydrophilic interaction liquid chromatography for the separation of ephedrines

James Heaton, Nicola Gray, David A. Cowan, Robert S. Plumb, Cristina Legido-Quigley, Norman W. Smith

Research output: Contribution to journal › Article › peer-review

45 Citations (Scopus)

Abstract

The separation of highly basic solutes is an ongoing challenge, especially in achieving suitable retention and peak shapes for compounds such as ephedrines that have both high pK(a) values (>= 9.3) and low lipophilicity (log P

Original language	English
Pages (from-to)	329 - 337
Number of pages	9
Journal	Journal of Chromatography A
Volume	1228
DOIs	https://doi.org/10.1016/j.chroma.2011.09.026
Publication status	Published - 9 Mar 2012

Access to Document

10.1016/j.chroma.2011.09.026

Cite this

@article{d11d6145b8ee47908054ebfd19920685,

title = "Comparison of reversed-phase and hydrophilic interaction liquid chromatography for the separation of ephedrines",

abstract = "The separation of highly basic solutes is an ongoing challenge, especially in achieving suitable retention and peak shapes for compounds such as ephedrines that have both high pK(a) values (>= 9.3) and low lipophilicity (log P ",

author = "James Heaton and Nicola Gray and Cowan, {David A.} and Plumb, {Robert S.} and Cristina Legido-Quigley and Smith, {Norman W.}",

year = "2012",

month = mar,

day = "9",

doi = "10.1016/j.chroma.2011.09.026",

language = "English",

volume = "1228",

pages = "329 -- 337",

journal = "Journal of Chromatography A",

publisher = "Elsevier",

}

TY - JOUR

T1 - Comparison of reversed-phase and hydrophilic interaction liquid chromatography for the separation of ephedrines

AU - Heaton, James

AU - Gray, Nicola

AU - Cowan, David A.

AU - Plumb, Robert S.

AU - Legido-Quigley, Cristina

AU - Smith, Norman W.

PY - 2012/3/9

Y1 - 2012/3/9

N2 - The separation of highly basic solutes is an ongoing challenge, especially in achieving suitable retention and peak shapes for compounds such as ephedrines that have both high pK(a) values (>= 9.3) and low lipophilicity (log P

AB - The separation of highly basic solutes is an ongoing challenge, especially in achieving suitable retention and peak shapes for compounds such as ephedrines that have both high pK(a) values (>= 9.3) and low lipophilicity (log P

U2 - 10.1016/j.chroma.2011.09.026

DO - 10.1016/j.chroma.2011.09.026

M3 - Article

VL - 1228

SP - 329

EP - 337

JO - Journal of Chromatography A

JF - Journal of Chromatography A

ER -

Comparison of reversed-phase and hydrophilic interaction liquid chromatography for the separation of ephedrines

Abstract

Access to Document

Fingerprint

Cite this