Comparison of sestamibi, thallium, echocardiography and PET for the detection of hibernating myocardium

TY - JOUR

T1 - Comparison of sestamibi, thallium, echocardiography and PET for the detection of hibernating myocardium

AU - Barrington, S F

AU - Chambers, J

AU - Hallett, W A

AU - O'Doherty, M J

AU - Roxburgh, J C

AU - Nunan, T O

PY - 2004/3

Y1 - 2004/3

N2 - The detection of hibernating myocardium is important because revascularisation results in improved function and prognosis in patients with hibernation but not in those with non-viable myocardium. The primary aim of this study was to compare the diagnostic accuracy of four techniques with respect to hibernation in the same study population with 6-12 months of follow-up. Twenty-five males underwent rest-stress sestamibi and delayed (>18 h) thallium scintigraphy, high-dose dobutamine stress echocardiography and nitrogen-13 ammonia/fluorine-18 fluorodeoxyglucose (NH3/FDG) positron emission tomography (PET). The pre-operative ejection fraction was 36.2% (+/-7.3%). Follow-up was 8.1 (+/-2.8) months. Using postoperative improvement in wall motion on echocardiography as the gold standard, 6/34 dysfunctional vascular territories were hibernating. The mean uptake of all tracers was significantly higher in hibernating than in non-viable territories (PNH3 uptake) and the pattern of response to dobutamine on echocardiography were also predictive of recovery (P

AB - The detection of hibernating myocardium is important because revascularisation results in improved function and prognosis in patients with hibernation but not in those with non-viable myocardium. The primary aim of this study was to compare the diagnostic accuracy of four techniques with respect to hibernation in the same study population with 6-12 months of follow-up. Twenty-five males underwent rest-stress sestamibi and delayed (>18 h) thallium scintigraphy, high-dose dobutamine stress echocardiography and nitrogen-13 ammonia/fluorine-18 fluorodeoxyglucose (NH3/FDG) positron emission tomography (PET). The pre-operative ejection fraction was 36.2% (+/-7.3%). Follow-up was 8.1 (+/-2.8) months. Using postoperative improvement in wall motion on echocardiography as the gold standard, 6/34 dysfunctional vascular territories were hibernating. The mean uptake of all tracers was significantly higher in hibernating than in non-viable territories (PNH3 uptake) and the pattern of response to dobutamine on echocardiography were also predictive of recovery (P

UR - http://www.scopus.com/inward/record.url?scp=1542318508&partnerID=8YFLogxK

U2 - 10.1007/s00259-003-1369-9

DO - 10.1007/s00259-003-1369-9

M3 - Article

SN - 1619-7089

VL - 31

SP - 355

EP - 361

JO - European Journal of Nuclear Medicine and Molecular Imaging

JF - European Journal of Nuclear Medicine and Molecular Imaging

IS - 3

ER -