Comparison of six quantitative methods for the measurement of bone turnover at the hip and lumbar spine using F-18-fluoride PET-CT

TY - JOUR

T1 - Comparison of six quantitative methods for the measurement of bone turnover at the hip and lumbar spine using F-18-fluoride PET-CT

AU - Puri, Tanuj

AU - Blake, Glen M

AU - Frost, Michelle L

AU - Siddique, Musib

AU - Moore, Amelia E B

AU - Marsden, Paul K

AU - Cook, Gary J R

AU - Fogelman, Ignac

AU - Curran, Kathleen M

PY - 2012/6

Y1 - 2012/6

N2 - Aim The aim of this study was to evaluate the relationship between different quantification methods used for the measurement of bone plasma clearance (K-i) using F-18-PET at the hip and lumbar spine. Methods Twelve healthy postmenopausal women aged 52-71 years were recruited. Each participant underwent 60-min dynamic F-18-PET scans at the lumbar spine and hip on two separate occasions with an injected activity of 90 and 180 MBq, respectively. Image-derived input functions were obtained at the aorta from the lumbar spine scans. K-i was evaluated using a three-compartment four-parameter model (Ki-4k), three-compartment three-parameter model (Ki-3k), Patlak analysis (Ki-Pat), spectral analysis (Ki-Spec) and deconvolution (Ki-Decon). Standardized uptake values (SUVs) were also measured. Results The Pearson correlation between Ki-4k and Ki-3k, Ki-Pat, Ki-Spec, Ki-Decon and SUV were 0.91, 0.97, 0.94, 0.95 and 0.93, respectively, with a significance of P less than 0.0001. The differences between the correlations measured using Fisher's Z-test were not significant (P>0.05). Bland-Altman analysis showed that the limits of agreement for K-i measured as the SD of the differences were 0.0082 (25.9%), 0.0062 (11.7%), 0.0098 (20.1%) and 0.0056 (25.5%) ml/min/ml, respectively, and the biases were -0.0081 (-23.8%), -0.0075 (-23.7%), -0.0107 (-29.5%) and -0.0015 (0.8%) ml/min/ml, respectively. Conclusion All five methods of quantification (Ki-3k, Ki-Pat, Ki-Spec, Ki-Decon and SUV) strongly correlated with Ki-4k. Although systematic differences of up to 29% were found between Ki-4k and the other methods (Ki-3k, Ki-Pat, Ki-Spec and Ki-Decon), these should not affect the conclusions of clinical studies, provided the methods are applied consistently. However, care should be taken when comparing reports that use different methods of quantification. 

AB - Aim The aim of this study was to evaluate the relationship between different quantification methods used for the measurement of bone plasma clearance (K-i) using F-18-PET at the hip and lumbar spine. Methods Twelve healthy postmenopausal women aged 52-71 years were recruited. Each participant underwent 60-min dynamic F-18-PET scans at the lumbar spine and hip on two separate occasions with an injected activity of 90 and 180 MBq, respectively. Image-derived input functions were obtained at the aorta from the lumbar spine scans. K-i was evaluated using a three-compartment four-parameter model (Ki-4k), three-compartment three-parameter model (Ki-3k), Patlak analysis (Ki-Pat), spectral analysis (Ki-Spec) and deconvolution (Ki-Decon). Standardized uptake values (SUVs) were also measured. Results The Pearson correlation between Ki-4k and Ki-3k, Ki-Pat, Ki-Spec, Ki-Decon and SUV were 0.91, 0.97, 0.94, 0.95 and 0.93, respectively, with a significance of P less than 0.0001. The differences between the correlations measured using Fisher's Z-test were not significant (P>0.05). Bland-Altman analysis showed that the limits of agreement for K-i measured as the SD of the differences were 0.0082 (25.9%), 0.0062 (11.7%), 0.0098 (20.1%) and 0.0056 (25.5%) ml/min/ml, respectively, and the biases were -0.0081 (-23.8%), -0.0075 (-23.7%), -0.0107 (-29.5%) and -0.0015 (0.8%) ml/min/ml, respectively. Conclusion All five methods of quantification (Ki-3k, Ki-Pat, Ki-Spec, Ki-Decon and SUV) strongly correlated with Ki-4k. Although systematic differences of up to 29% were found between Ki-4k and the other methods (Ki-3k, Ki-Pat, Ki-Spec and Ki-Decon), these should not affect the conclusions of clinical studies, provided the methods are applied consistently. However, care should be taken when comparing reports that use different methods of quantification. 

KW - Hip Joint

KW - Bone Remodeling

KW - Reproducibility of Results

KW - Radiopharmaceuticals

KW - Humans

KW - Fluorodeoxyglucose F18

KW - Algorithms

KW - Aged

KW - Middle Aged

KW - Female

KW - Positron-Emission Tomography and Computed Tomography

KW - Lumbar Vertebrae

U2 - 10.1097/MNM.0b013e3283512adb

DO - 10.1097/MNM.0b013e3283512adb

M3 - Article

C2 - 22441132

SN - 0143-3636

VL - 33

SP - 597

EP - 606

JO - Nuclear Medicine Communications

JF - Nuclear Medicine Communications

IS - 6

M1 - N/A

ER -