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Comparison of the Diagnostic Accuracy of Plasma N-Terminal Pro-Brain Natriuretic Peptide in Patients 80 Years of Age with Heart Failure

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Comparison of the Diagnostic Accuracy of Plasma N-Terminal Pro-Brain Natriuretic Peptide in Patients 80 Years of Age with Heart Failure. / Draper, Jane; Webb, Jessica; Jackson, Tom; Jones, Hamish; Rinaldi, Christopher A; Schiff, Rebekah; McDonagh, Theresa; Razavi, Reza; Carr-White, Gerald.

In: American Journal of Cardiology, 13.09.2018.

Research output: Contribution to journalArticle

Harvard

Draper, J, Webb, J, Jackson, T, Jones, H, Rinaldi, CA, Schiff, R, McDonagh, T, Razavi, R & Carr-White, G 2018, 'Comparison of the Diagnostic Accuracy of Plasma N-Terminal Pro-Brain Natriuretic Peptide in Patients 80 Years of Age with Heart Failure', American Journal of Cardiology. https://doi.org/10.1016/j.amjcard.2018.09.004

APA

Draper, J., Webb, J., Jackson, T., Jones, H., Rinaldi, C. A., Schiff, R., ... Carr-White, G. (2018). Comparison of the Diagnostic Accuracy of Plasma N-Terminal Pro-Brain Natriuretic Peptide in Patients 80 Years of Age with Heart Failure. American Journal of Cardiology. https://doi.org/10.1016/j.amjcard.2018.09.004

Vancouver

Draper J, Webb J, Jackson T, Jones H, Rinaldi CA, Schiff R et al. Comparison of the Diagnostic Accuracy of Plasma N-Terminal Pro-Brain Natriuretic Peptide in Patients 80 Years of Age with Heart Failure. American Journal of Cardiology. 2018 Sep 13. https://doi.org/10.1016/j.amjcard.2018.09.004

Author

Draper, Jane ; Webb, Jessica ; Jackson, Tom ; Jones, Hamish ; Rinaldi, Christopher A ; Schiff, Rebekah ; McDonagh, Theresa ; Razavi, Reza ; Carr-White, Gerald. / Comparison of the Diagnostic Accuracy of Plasma N-Terminal Pro-Brain Natriuretic Peptide in Patients 80 Years of Age with Heart Failure. In: American Journal of Cardiology. 2018.

Bibtex Download

@article{3f5334980af34ef28a98e6098b7f02d6,
title = "Comparison of the Diagnostic Accuracy of Plasma N-Terminal Pro-Brain Natriuretic Peptide in Patients 80 Years of Age with Heart Failure",
abstract = "Plasma N-Terminal Pro-Brain Natriuretic Peptide (NTproBNP) is known to increase with age however the performance of this biomaker is unclear in patients >80. This study sought to define the diagnostic accuracy of plasma NTproBNP in patients > 80 in a large unselected population of heart failure (HF) patients admitted to a Tertiary Hospital in the United Kingdom. 1995 consecutive patients over a 12 month period were screened for HF through our NTproBNP led heart failure service. 413 patients had their first presentation of HF and 36.1{\%} of these patients were > 80. There was a reduction in accuracy of NTproBNP with age according to the Area under the curve (AUC), with an AUC for all HF patients of 0.734 and a 7.5{\%} reduction in receiver operating characteristic curve (ROC) area for patients > 80 years compared to those under 60-79 years of age. The lowest NTproBNP recorded for patients with HF > 80 years of age was 466pg/mL. In HF patients > 80, 40.6{\%} patients were diagnosed with HFrEF, 31.1{\%} with HFpEF and 28.2{\%} with HFmrEF. Overall NTproBNP is less accurate at identifying HF in patients > 80 years of age and the lowest NTproBNP recorded for a HF patient was 466pg/mL suggesting that the NTproBNP threshold for ruling out HF in patients >80 years of age should be modified.",
keywords = "N-Terminal Pro-Brain Natriuretic Peptide (NTproBNP), Heart Failure (HF), Area under the curve (AUC)",
author = "Jane Draper and Jessica Webb and Tom Jackson and Hamish Jones and Rinaldi, {Christopher A} and Rebekah Schiff and Theresa McDonagh and Reza Razavi and Gerald Carr-White",
year = "2018",
month = "9",
day = "13",
doi = "10.1016/j.amjcard.2018.09.004",
language = "English",
journal = "American Journal of Cardiology",
issn = "0002-9149",
publisher = "Elsevier Inc.",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Comparison of the Diagnostic Accuracy of Plasma N-Terminal Pro-Brain Natriuretic Peptide in Patients 80 Years of Age with Heart Failure

AU - Draper, Jane

AU - Webb, Jessica

AU - Jackson, Tom

AU - Jones, Hamish

AU - Rinaldi, Christopher A

AU - Schiff, Rebekah

AU - McDonagh, Theresa

AU - Razavi, Reza

AU - Carr-White, Gerald

PY - 2018/9/13

Y1 - 2018/9/13

N2 - Plasma N-Terminal Pro-Brain Natriuretic Peptide (NTproBNP) is known to increase with age however the performance of this biomaker is unclear in patients >80. This study sought to define the diagnostic accuracy of plasma NTproBNP in patients > 80 in a large unselected population of heart failure (HF) patients admitted to a Tertiary Hospital in the United Kingdom. 1995 consecutive patients over a 12 month period were screened for HF through our NTproBNP led heart failure service. 413 patients had their first presentation of HF and 36.1% of these patients were > 80. There was a reduction in accuracy of NTproBNP with age according to the Area under the curve (AUC), with an AUC for all HF patients of 0.734 and a 7.5% reduction in receiver operating characteristic curve (ROC) area for patients > 80 years compared to those under 60-79 years of age. The lowest NTproBNP recorded for patients with HF > 80 years of age was 466pg/mL. In HF patients > 80, 40.6% patients were diagnosed with HFrEF, 31.1% with HFpEF and 28.2% with HFmrEF. Overall NTproBNP is less accurate at identifying HF in patients > 80 years of age and the lowest NTproBNP recorded for a HF patient was 466pg/mL suggesting that the NTproBNP threshold for ruling out HF in patients >80 years of age should be modified.

AB - Plasma N-Terminal Pro-Brain Natriuretic Peptide (NTproBNP) is known to increase with age however the performance of this biomaker is unclear in patients >80. This study sought to define the diagnostic accuracy of plasma NTproBNP in patients > 80 in a large unselected population of heart failure (HF) patients admitted to a Tertiary Hospital in the United Kingdom. 1995 consecutive patients over a 12 month period were screened for HF through our NTproBNP led heart failure service. 413 patients had their first presentation of HF and 36.1% of these patients were > 80. There was a reduction in accuracy of NTproBNP with age according to the Area under the curve (AUC), with an AUC for all HF patients of 0.734 and a 7.5% reduction in receiver operating characteristic curve (ROC) area for patients > 80 years compared to those under 60-79 years of age. The lowest NTproBNP recorded for patients with HF > 80 years of age was 466pg/mL. In HF patients > 80, 40.6% patients were diagnosed with HFrEF, 31.1% with HFpEF and 28.2% with HFmrEF. Overall NTproBNP is less accurate at identifying HF in patients > 80 years of age and the lowest NTproBNP recorded for a HF patient was 466pg/mL suggesting that the NTproBNP threshold for ruling out HF in patients >80 years of age should be modified.

KW - N-Terminal Pro-Brain Natriuretic Peptide (NTproBNP)

KW - Heart Failure (HF)

KW - Area under the curve (AUC)

U2 - 10.1016/j.amjcard.2018.09.004

DO - 10.1016/j.amjcard.2018.09.004

M3 - Article

JO - American Journal of Cardiology

JF - American Journal of Cardiology

SN - 0002-9149

ER -

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