Compassionate Use of Cefiderocol as Adjunctive Treatment of Native Aortic Valve Endocarditis Due to Extremely Drug-resistant Pseudomonas aeruginosa

Jonathan D. Edgeworth; Domenico Merante; Sanjay Patel; Christopher Young; Paul Jones; Seema Vithlani; Duncan Wyncoll; Peter Roberts; Andrew Jones; Tsutae Den Nagata; Mari Ariyasu; David M. Livermore; Richard Beale

doi:10.1093/cid/ciy963

Compassionate Use of Cefiderocol as Adjunctive Treatment of Native Aortic Valve Endocarditis Due to Extremely Drug-resistant Pseudomonas aeruginosa

Jonathan D. Edgeworth, Domenico Merante, Sanjay Patel, Christopher Young, Paul Jones, Seema Vithlani, Duncan Wyncoll, Peter Roberts, Andrew Jones, Tsutae Den Nagata, Mari Ariyasu, David M. Livermore, Richard Beale

Research output: Contribution to journal › Article › peer-review

54 Citations (Scopus)

Abstract

Serious infections such as endocarditis due to extremely drug-resistance gram-negative bacteria are an increasing challenge. Here, we present successful adjunctive use of cefiderocol for a patient with persistently bacteremic healthcare-associated native aortic valve endocarditis due to an extended-spectrum beta-lactamase-positive Pseudomonas aeruginosa susceptible in vitro only to colistin, following failure of conventional therapeutic options.

Original language	English
Pages (from-to)	1932-1934
Number of pages	3
Journal	Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Volume	68
Issue number	11
DOIs	https://doi.org/10.1093/cid/ciy963
Publication status	Published - 12 Dec 2018

Keywords

Pseudomonas aeruginosa
cefiderocol
drug resistance
endocarditis
microbial

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10.1093/cid/ciy963

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Edgeworth, J. D., Merante, D., Patel, S., Young, C., Jones, P., Vithlani, S., Wyncoll, D., Roberts, P., Jones, A., Den Nagata, T., Ariyasu, M., Livermore, D. M., & Beale, R. (2018). Compassionate Use of Cefiderocol as Adjunctive Treatment of Native Aortic Valve Endocarditis Due to Extremely Drug-resistant Pseudomonas aeruginosa. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 68(11), 1932-1934. https://doi.org/10.1093/cid/ciy963

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title = "Compassionate Use of Cefiderocol as Adjunctive Treatment of Native Aortic Valve Endocarditis Due to Extremely Drug-resistant Pseudomonas aeruginosa",

abstract = "Serious infections such as endocarditis due to extremely drug-resistance gram-negative bacteria are an increasing challenge. Here, we present successful adjunctive use of cefiderocol for a patient with persistently bacteremic healthcare-associated native aortic valve endocarditis due to an extended-spectrum beta-lactamase-positive Pseudomonas aeruginosa susceptible in vitro only to colistin, following failure of conventional therapeutic options.",

keywords = "Pseudomonas aeruginosa, cefiderocol, drug resistance, endocarditis, microbial",

author = "Edgeworth, {Jonathan D.} and Domenico Merante and Sanjay Patel and Christopher Young and Paul Jones and Seema Vithlani and Duncan Wyncoll and Peter Roberts and Andrew Jones and {Den Nagata}, Tsutae and Mari Ariyasu and Livermore, {David M.} and Richard Beale",

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Edgeworth, JD, Merante, D, Patel, S, Young, C, Jones, P, Vithlani, S, Wyncoll, D, Roberts, P, Jones, A, Den Nagata, T, Ariyasu, M, Livermore, DM & Beale, R 2018, 'Compassionate Use of Cefiderocol as Adjunctive Treatment of Native Aortic Valve Endocarditis Due to Extremely Drug-resistant Pseudomonas aeruginosa', Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, vol. 68, no. 11, pp. 1932-1934. https://doi.org/10.1093/cid/ciy963

Compassionate Use of Cefiderocol as Adjunctive Treatment of Native Aortic Valve Endocarditis Due to Extremely Drug-resistant Pseudomonas aeruginosa. / Edgeworth, Jonathan D.; Merante, Domenico; Patel, Sanjay et al.
In: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, Vol. 68, No. 11, 12.12.2018, p. 1932-1934.

Research output: Contribution to journal › Article › peer-review

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T1 - Compassionate Use of Cefiderocol as Adjunctive Treatment of Native Aortic Valve Endocarditis Due to Extremely Drug-resistant Pseudomonas aeruginosa

AU - Edgeworth, Jonathan D.

AU - Merante, Domenico

AU - Patel, Sanjay

AU - Young, Christopher

AU - Jones, Paul

AU - Vithlani, Seema

AU - Wyncoll, Duncan

AU - Roberts, Peter

AU - Jones, Andrew

AU - Den Nagata, Tsutae

AU - Ariyasu, Mari

AU - Livermore, David M.

AU - Beale, Richard

PY - 2018/12/12

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AB - Serious infections such as endocarditis due to extremely drug-resistance gram-negative bacteria are an increasing challenge. Here, we present successful adjunctive use of cefiderocol for a patient with persistently bacteremic healthcare-associated native aortic valve endocarditis due to an extended-spectrum beta-lactamase-positive Pseudomonas aeruginosa susceptible in vitro only to colistin, following failure of conventional therapeutic options.

KW - Pseudomonas aeruginosa

KW - cefiderocol

KW - drug resistance

KW - endocarditis

KW - microbial

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VL - 68

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JO - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

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Edgeworth JD, Merante D, Patel S, Young C, Jones P, Vithlani S et al. Compassionate Use of Cefiderocol as Adjunctive Treatment of Native Aortic Valve Endocarditis Due to Extremely Drug-resistant Pseudomonas aeruginosa. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2018 Dec 12;68(11):1932-1934. doi: 10.1093/cid/ciy963

Compassionate Use of Cefiderocol as Adjunctive Treatment of Native Aortic Valve Endocarditis Due to Extremely Drug-resistant Pseudomonas aeruginosa

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