King's College London

Funding Information: Thank you to all the participants of the LonDownS study and their families and caregivers. We also thank our NHS network of sites that helped to identify participants. Recruitment support and data collection for the LonDownS study has been provided by Carla Startin, Sarah Hamburg, Rosalyn Hithersay, Fedal Sinai, Marie‐Stephanie Cahart, and Deborah Ness (all based at both the department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK, and Division of Psychiatry, University College London, London, UK). Genetic data extraction was supported by Kin Y. Mok (Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK). The authors thank Professor Claire Harris and her team (Newcastle University) for preparation of control samples. This work is supported by the UK Dementia Research Institute, which receives its funding from UK DRI Ltd, funded by the UK Medical Research Council, Alzheimer's Society, and Alzheimer's Research UK. AV is supported by a ARUK studentship. SP is supported by a fellowship from the Alzheimer's Society (AS‐CP‐18‐0020). The LonDownS study is supported by the Medical Research Council, and via Joint Programming Initiative on Neurodegenerative Diseases Research (JPND) and CoEN (grant number: MRC S011277/1, MR/R024901/1, MR/S005145/1). Other funders include Jérôme Lejeune Foundation. The LonDownS Consortium: The LonDownS Consortium principal investigators are Andre Strydom (chief investigator), Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK, and Division of Psychiatry, University College London, London, UK; Elizabeth Fisher, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK; Dean Nizetic, Blizard Institute, Barts and the London School of Medicine, Queen Mary University of London, London, UK, and Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore; John Hardy, Reta Lila Weston Institute, Institute of Neurology, University College London, London, UK, and UK Dementia Research Institute at UCL, London, UK; Victor Tybulewicz, Francis Crick Institute, London, UK, and Department of Medicine, Imperial College London, London, UK; and Annette Karmiloff‐Smith (Birkbeck University of London, London, UK, deceased). Publisher Copyright: © 2022 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.