Complement Fragment C3a Controls Mutual Cell Attraction during Collective Cell Migration

Carlos Carmona-Fontaine; Eric Theveneau; Apostolia Tzekou; Masazumi Tada; Mae Woods; Karen M. Page; Madeline Parsons; John D. Lambris; Roberto Mayor

doi:10.1016/j.devcel.2011.10.012

Complement Fragment C3a Controls Mutual Cell Attraction during Collective Cell Migration

Carlos Carmona-Fontaine, Eric Theveneau, Apostolia Tzekou, Masazumi Tada, Mae Woods, Karen M. Page, Madeline Parsons, John D. Lambris, Roberto Mayor

Research output: Contribution to journal › Article › peer-review

250 Citations (Scopus)

Abstract

Collective cell migration is a mode of movement crucial for morphogenesis and cancer metastasis. However, little is known about how migratory cells coordinate collectively. Here we show that mutual cell-cell attraction (named here coattraction) is required to maintain cohesive clusters of migrating mesenchymal cells. Coattraction can counterbalance the natural tendency of cells to disperse via mechanisms such as contact inhibition and epithelial-to-mesenchymal transition. Neural crest cells are coattracted via the complement fragment C3a and its receptor C3aR, revealing an unexpected role of complement proteins in early vertebrate development. Loss of coattraction disrupts collective and coordinated movements of these cells. We propose that coattraction and contact inhibition act in concert to allow cell collectives to self-organize and respond efficiently to external signals, such as chemoattractants and repellents.

Original language	English
Pages (from-to)	1026-1037
Number of pages	12
Journal	Developmental Cell
Volume	21
Issue number	6
DOIs	https://doi.org/10.1016/j.devcel.2011.10.012
Publication status	Published - 13 Dec 2011

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title = "Complement Fragment C3a Controls Mutual Cell Attraction during Collective Cell Migration",

abstract = "Collective cell migration is a mode of movement crucial for morphogenesis and cancer metastasis. However, little is known about how migratory cells coordinate collectively. Here we show that mutual cell-cell attraction (named here coattraction) is required to maintain cohesive clusters of migrating mesenchymal cells. Coattraction can counterbalance the natural tendency of cells to disperse via mechanisms such as contact inhibition and epithelial-to-mesenchymal transition. Neural crest cells are coattracted via the complement fragment C3a and its receptor C3aR, revealing an unexpected role of complement proteins in early vertebrate development. Loss of coattraction disrupts collective and coordinated movements of these cells. We propose that coattraction and contact inhibition act in concert to allow cell collectives to self-organize and respond efficiently to external signals, such as chemoattractants and repellents.",

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AU - Carmona-Fontaine, Carlos

AU - Theveneau, Eric

AU - Tzekou, Apostolia

AU - Tada, Masazumi

AU - Woods, Mae

AU - Page, Karen M.

AU - Parsons, Madeline

AU - Lambris, John D.

AU - Mayor, Roberto

PY - 2011/12/13

Y1 - 2011/12/13

N2 - Collective cell migration is a mode of movement crucial for morphogenesis and cancer metastasis. However, little is known about how migratory cells coordinate collectively. Here we show that mutual cell-cell attraction (named here coattraction) is required to maintain cohesive clusters of migrating mesenchymal cells. Coattraction can counterbalance the natural tendency of cells to disperse via mechanisms such as contact inhibition and epithelial-to-mesenchymal transition. Neural crest cells are coattracted via the complement fragment C3a and its receptor C3aR, revealing an unexpected role of complement proteins in early vertebrate development. Loss of coattraction disrupts collective and coordinated movements of these cells. We propose that coattraction and contact inhibition act in concert to allow cell collectives to self-organize and respond efficiently to external signals, such as chemoattractants and repellents.

AB - Collective cell migration is a mode of movement crucial for morphogenesis and cancer metastasis. However, little is known about how migratory cells coordinate collectively. Here we show that mutual cell-cell attraction (named here coattraction) is required to maintain cohesive clusters of migrating mesenchymal cells. Coattraction can counterbalance the natural tendency of cells to disperse via mechanisms such as contact inhibition and epithelial-to-mesenchymal transition. Neural crest cells are coattracted via the complement fragment C3a and its receptor C3aR, revealing an unexpected role of complement proteins in early vertebrate development. Loss of coattraction disrupts collective and coordinated movements of these cells. We propose that coattraction and contact inhibition act in concert to allow cell collectives to self-organize and respond efficiently to external signals, such as chemoattractants and repellents.

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JO - Developmental Cell

JF - Developmental Cell

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Complement Fragment C3a Controls Mutual Cell Attraction during Collective Cell Migration

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