Complement — tapping into new sites and effector systems

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    251 Citations (Scopus)

    Abstract

    Complement is traditionally known to be a system of serum proteins that provide protection against pathogens through direct cell lysis and the mobilization of innate and adaptive immunity. However, recent work indicates that the complement system has additional physiological roles beyond those in host defence. In this Opinion article, we describe the new modes and locations of complement activation that enable it to interact with other cell effector systems, such as growth factor receptors, inflammasomes and metabolic pathways. We propose that the location of complement activation dictates its function.
    Original languageEnglish
    Pages (from-to)811-820
    Number of pages10
    JournalNATURE REVIEWS IMMUNOLOGY
    Volume14
    Early online date14 Nov 2014
    DOIs
    Publication statusPublished - Dec 2014

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