Comprehensive assessment of left intraventricular hemodynamics using a finite element method: An application to dilated cardiomyopathy patients

Pamela Franco, Julio Sotelo, Cristian Montalba, Bram Ruijsink, Eric Kerfoot, David Nordsletten, Joaquín Mura, Daniel Hurtado, Sergio Uribe*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

In this paper, we applied a method for quantifying several left intraventricular hemodynamic parameters from 4D Flow data and its application in a proof-of-concept study in dilated cardiomyopathy (DCM) patients. In total, 12 healthy volunteers and 13 DCM patients under treatment underwent short-axis cine b-SSFP and 4D Flow MRI. Following 3D segmentation of the left ventricular (LV) cavity and registration of both sequences, several hemodynamic parameters were calculated at peak systole, e-wave, and end-diastole using a finite element approach. Sensitivity, inter-and intra-observer reproducibility of hemodynamic parameters were evaluated by analyzing LV segmentation. A local analysis was performed by dividing the LV cavity into 16 regions. We found significant differences between volunteers and patients in velocity, vorticity, viscous dissipation, energy loss, and kinetic energy at peak systole and e-wave. Furthermore, although five patients showed a recovered ejection fraction after treatment, their hemodynamic parameters remained low. We obtained several hemodynamic parameters with high inter-and intra-observer reproducibility. The sensitivity study revealed that hemodynamic parameters showed a higher accuracy when the segmentation underestimates the LV volumes. Our approach was able to identify abnormal flow patterns in DCM patients compared to volunteers and can be applied to any other cardiovascular diseases.

Original languageEnglish
Article number11165
JournalApplied Sciences (Switzerland)
Volume11
Issue number23
Early online date25 Nov 2021
DOIs
Publication statusPublished - 1 Dec 2021

Keywords

  • 4D flow MRI
  • Dilated cardiomyopathy
  • Finite elements
  • Flow quantification
  • Left ventricle

Fingerprint

Dive into the research topics of 'Comprehensive assessment of left intraventricular hemodynamics using a finite element method: An application to dilated cardiomyopathy patients'. Together they form a unique fingerprint.

Cite this