TY - JOUR
T1 - COMPULS
T2 - Design of a multicenter phenotypic, cognitive, genetic, and magnetic resonance imaging study in children with compulsive syndromes
AU - Naaijen, Jilly
AU - de Ruiter, Saskia
AU - Zwiers, Marcel P.
AU - Glennon, Jeffrey C.
AU - Durston, Sarah
AU - Lythgoe, David J.
AU - Williams, Steven C R
AU - Banaschewski, Tobias
AU - Brandeis, Daniel
AU - Franke, Barbara
AU - Buitelaar, Jan K.
PY - 2016/10/26
Y1 - 2016/10/26
N2 - Background: Compulsivity, the closely linked trait impulsivity and addictive behaviour are associated with several neurodevelopmental disorders, including attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), and obsessive compulsive disorder (OCD). All three disorders show impaired fronto-striatal functioning, which may be related to altered glutamatergic signalling. Genetic factors are also thought to play an important role in the aetiology of compulsivity-related disorders. Methods: The COMPULS study is a multi-center study designed to investigate the relationship between the traits compulsivity, impulsivity, and, to a lesser extent, addictive behaviour within and across the neurodevelopmental disorders ADHD, ASD, and OCD. This will be done at the phenotypic, cognitive, neural, and genetic level. In total, 240 participants will take part in COMPULS across four different sites in Europe. Data collection will include diagnostic interviews, behavioural questionnaires, cognitive measures, structural, functional and spectral neuroimaging, and genome-wide genetic information. Discussion: The COMPULS study will offer the unique opportunity to investigate several key aspects of compulsivity across a large cohort of ADHD, ASD and OCD patients.
AB - Background: Compulsivity, the closely linked trait impulsivity and addictive behaviour are associated with several neurodevelopmental disorders, including attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), and obsessive compulsive disorder (OCD). All three disorders show impaired fronto-striatal functioning, which may be related to altered glutamatergic signalling. Genetic factors are also thought to play an important role in the aetiology of compulsivity-related disorders. Methods: The COMPULS study is a multi-center study designed to investigate the relationship between the traits compulsivity, impulsivity, and, to a lesser extent, addictive behaviour within and across the neurodevelopmental disorders ADHD, ASD, and OCD. This will be done at the phenotypic, cognitive, neural, and genetic level. In total, 240 participants will take part in COMPULS across four different sites in Europe. Data collection will include diagnostic interviews, behavioural questionnaires, cognitive measures, structural, functional and spectral neuroimaging, and genome-wide genetic information. Discussion: The COMPULS study will offer the unique opportunity to investigate several key aspects of compulsivity across a large cohort of ADHD, ASD and OCD patients.
KW - ADHD
KW - ASD
KW - Compulsivity
KW - Fronto-striatal circuit
KW - Glutamate
KW - OCD
UR - http://www.scopus.com/inward/record.url?scp=84992471290&partnerID=8YFLogxK
U2 - 10.1186/s12888-016-1072-6
DO - 10.1186/s12888-016-1072-6
M3 - Article
C2 - 27782808
SN - 1471-244X
VL - 16
SP - 361
JO - BMC Psychiatry
JF - BMC Psychiatry
IS - 1
M1 - 361
ER -