Computational analysis of coronary blood flow: The role of asynchronous pacing and arrhythmias

TY - JOUR

T1 - Computational analysis of coronary blood flow

T2 - The role of asynchronous pacing and arrhythmias

AU - Gamilov, Timur

AU - Kopylov, Philipp

AU - Serova, Maria

AU - Syunyaev, Roman

AU - Pikunov, Andrey

AU - Belova, Sofya

AU - Liang, Fuyou

AU - Alastruey, Jordi

AU - Simakov, Sergey

PY - 2020/8

Y1 - 2020/8

N2 - In this work we present a one-dimensional (1D) mathematical model of the coronary circulation and use it to study the effects of arrhythmias on coronary blood flow (CBF). Hydrodynamical models are rarely used to study arrhythmias' effects on CBF. Our model accounts for action potential duration, which updates the length of systole depending on the heart rate. It also includes dependency of stroke volume on heart rate, which is based on clinical data. We apply the new methodology to the computational evaluation of CBF during interventricular asynchrony due to cardiac pacing and some types of arrhythmias including tachycardia, bradycardia, long QT syndrome and premature ventricular contraction (bigeminy, trigeminy, quadrigeminy). We find that CBF can be significantly affected by arrhythmias. CBF at rest (60 bpm) is 26% lower in LCA and 22% lower in RCA for long QT syndrome. During bigeminy, trigeminy and quadrigeminy, respectively, CBF decreases by 28%, 19% and 14% with respect to a healthy case.

AB - In this work we present a one-dimensional (1D) mathematical model of the coronary circulation and use it to study the effects of arrhythmias on coronary blood flow (CBF). Hydrodynamical models are rarely used to study arrhythmias' effects on CBF. Our model accounts for action potential duration, which updates the length of systole depending on the heart rate. It also includes dependency of stroke volume on heart rate, which is based on clinical data. We apply the new methodology to the computational evaluation of CBF during interventricular asynchrony due to cardiac pacing and some types of arrhythmias including tachycardia, bradycardia, long QT syndrome and premature ventricular contraction (bigeminy, trigeminy, quadrigeminy). We find that CBF can be significantly affected by arrhythmias. CBF at rest (60 bpm) is 26% lower in LCA and 22% lower in RCA for long QT syndrome. During bigeminy, trigeminy and quadrigeminy, respectively, CBF decreases by 28%, 19% and 14% with respect to a healthy case.

KW - 1D haemodynamics

KW - Bradycardia

KW - Cardiac pacing

KW - Coronary circulation

KW - Interventricular asynchrony

KW - Long QT syndrome

KW - Premature ventricular contraction

KW - Systole variations

KW - Tachycardia

UR - http://www.scopus.com/inward/record.url?scp=85089592577&partnerID=8YFLogxK

U2 - 10.3390/MATH8081205

DO - 10.3390/MATH8081205

M3 - Article

AN - SCOPUS:85089592577

SN - 0025-570X

VL - 8

JO - Mathematics

JF - Mathematics

IS - 8

M1 - 1205

ER -