Computational analysis of the importance of flow synchrony for cardiac ventricular assist devices

Matthew McCormick; David Nordsletten; Pablo Lamata de la Orden; Nicolas Smith

doi:10.1016/j.compbiomed.2014.03.013

Computational analysis of the importance of flow synchrony for cardiac ventricular assist devices

Matthew McCormick, David Nordsletten, Pablo Lamata de la Orden, Nicolas Smith

Biomedical Engineering Department

University of Oxford

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

This paper presents a patient customised fluid-solid mechanics model of the left ventricle (LV) supported by a left ventricular assist device (LVAD). Six simulations were conducted across a range of LVAD flow protocols (constant flow, sinusoidal in-sync and sinusoidal counter-sync with respect to the cardiac cycle) at two different LVAD flow rates selected so that the aortic valve would either open (60mLs(-1)) or remain shut (80mLs(-1)). The simulation results indicate that varying LVAD flow in-sync with the cardiac cycle improves both myocardial unloading and the residence times of blood in the left ventricle. In the simulations, increasing LVAD flow during myocardial contraction and decreasing it during diastole improved the mixing of blood in the LV cavity. Additionally, this flow protocol had the effect of partly homogenising work across the myocardium when the aortic valve did not open, reducing myocardial stress and thereby improving unloading.

Original language	English
Pages (from-to)	83-94
Number of pages	12
Journal	Computers in Biology and Medicine
Volume	49
DOIs	https://doi.org/10.1016/j.compbiomed.2014.03.013
Publication status	Published - 1 Jun 2014

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title = "Computational analysis of the importance of flow synchrony for cardiac ventricular assist devices",

abstract = "This paper presents a patient customised fluid-solid mechanics model of the left ventricle (LV) supported by a left ventricular assist device (LVAD). Six simulations were conducted across a range of LVAD flow protocols (constant flow, sinusoidal in-sync and sinusoidal counter-sync with respect to the cardiac cycle) at two different LVAD flow rates selected so that the aortic valve would either open (60mLs(-1)) or remain shut (80mLs(-1)). The simulation results indicate that varying LVAD flow in-sync with the cardiac cycle improves both myocardial unloading and the residence times of blood in the left ventricle. In the simulations, increasing LVAD flow during myocardial contraction and decreasing it during diastole improved the mixing of blood in the LV cavity. Additionally, this flow protocol had the effect of partly homogenising work across the myocardium when the aortic valve did not open, reducing myocardial stress and thereby improving unloading.",

author = "Matthew McCormick and David Nordsletten and {Lamata de la Orden}, Pablo and Nicolas Smith",

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doi = "10.1016/j.compbiomed.2014.03.013",

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T1 - Computational analysis of the importance of flow synchrony for cardiac ventricular assist devices

AU - McCormick, Matthew

AU - Nordsletten, David

AU - Lamata de la Orden, Pablo

AU - Smith, Nicolas

PY - 2014/6/1

Y1 - 2014/6/1

N2 - This paper presents a patient customised fluid-solid mechanics model of the left ventricle (LV) supported by a left ventricular assist device (LVAD). Six simulations were conducted across a range of LVAD flow protocols (constant flow, sinusoidal in-sync and sinusoidal counter-sync with respect to the cardiac cycle) at two different LVAD flow rates selected so that the aortic valve would either open (60mLs(-1)) or remain shut (80mLs(-1)). The simulation results indicate that varying LVAD flow in-sync with the cardiac cycle improves both myocardial unloading and the residence times of blood in the left ventricle. In the simulations, increasing LVAD flow during myocardial contraction and decreasing it during diastole improved the mixing of blood in the LV cavity. Additionally, this flow protocol had the effect of partly homogenising work across the myocardium when the aortic valve did not open, reducing myocardial stress and thereby improving unloading.

AB - This paper presents a patient customised fluid-solid mechanics model of the left ventricle (LV) supported by a left ventricular assist device (LVAD). Six simulations were conducted across a range of LVAD flow protocols (constant flow, sinusoidal in-sync and sinusoidal counter-sync with respect to the cardiac cycle) at two different LVAD flow rates selected so that the aortic valve would either open (60mLs(-1)) or remain shut (80mLs(-1)). The simulation results indicate that varying LVAD flow in-sync with the cardiac cycle improves both myocardial unloading and the residence times of blood in the left ventricle. In the simulations, increasing LVAD flow during myocardial contraction and decreasing it during diastole improved the mixing of blood in the LV cavity. Additionally, this flow protocol had the effect of partly homogenising work across the myocardium when the aortic valve did not open, reducing myocardial stress and thereby improving unloading.

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DO - 10.1016/j.compbiomed.2014.03.013

M3 - Article

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SN - 0010-4825

VL - 49

SP - 83

EP - 94

JO - Computers in Biology and Medicine

JF - Computers in Biology and Medicine

ER -

Computational analysis of the importance of flow synchrony for cardiac ventricular assist devices

Abstract

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