Computational Modelling Enabling In Silico Trials for Cardiac Physiologic Pacing

TY - JOUR

T1 - Computational Modelling Enabling In Silico Trials for Cardiac Physiologic Pacing

AU - Strocchi, Marina

AU - Wijesuriya, Nadeev

AU - Mehta, Vishal

AU - de Vere, Felicity

AU - Rinaldi, Christopher A.

AU - Niederer, Steven A.

N1 - Publisher Copyright: © The Author(s) 2023.

PY - 2024/6

Y1 - 2024/6

N2 - Conduction system pacing (CSP) has the potential to achieve physiological-paced activation by pacing the ventricular conduction system. Before CSP is adopted in standard clinical practice, large, randomised, and multi-centre trials are required to investigate CSP safety and efficacy compared to standard biventricular pacing (BVP). Furthermore, there are unanswered questions about pacing thresholds required to achieve optimal pacing delivery while preventing device battery draining, and about which patient groups are more likely to benefit from CSP rather than BVP. In silico studies have been increasingly used to investigate mechanisms underlying changes in cardiac function in response to pathologies and treatment. In the context of CSP, they have been used to improve our understanding of conduction system capture to optimise CSP delivery and battery life, and noninvasively compare different pacing methods on different patient groups. In this review, we discuss the in silico studies published to date investigating different aspects of CSP delivery. Graphical Abstract: (Figure presented.)

AB - Conduction system pacing (CSP) has the potential to achieve physiological-paced activation by pacing the ventricular conduction system. Before CSP is adopted in standard clinical practice, large, randomised, and multi-centre trials are required to investigate CSP safety and efficacy compared to standard biventricular pacing (BVP). Furthermore, there are unanswered questions about pacing thresholds required to achieve optimal pacing delivery while preventing device battery draining, and about which patient groups are more likely to benefit from CSP rather than BVP. In silico studies have been increasingly used to investigate mechanisms underlying changes in cardiac function in response to pathologies and treatment. In the context of CSP, they have been used to improve our understanding of conduction system capture to optimise CSP delivery and battery life, and noninvasively compare different pacing methods on different patient groups. In this review, we discuss the in silico studies published to date investigating different aspects of CSP delivery. Graphical Abstract: (Figure presented.)

KW - Cardiac resynchronization therapy

KW - Conduction system pacing

KW - His bundle pacing

KW - In silico

KW - In silico trials

KW - Left bundle pacing

KW - Modelling

UR - http://www.scopus.com/inward/record.url?scp=85174619136&partnerID=8YFLogxK

U2 - 10.1007/s12265-023-10453-y

DO - 10.1007/s12265-023-10453-y

M3 - Review article

C2 - 37870689

AN - SCOPUS:85174619136

SN - 1937-5387

VL - 17

SP - 685

EP - 694

JO - Journal of cardiovascular translational research

JF - Journal of cardiovascular translational research

IS - 3

ER -