Computational models of ventricular arrhythmia mechanisms: Recent developments and future prospects

R. H. Clayton; M. J. Bishop

doi:10.1016/j.ddmod.2014.04.002

Computational models of ventricular arrhythmia mechanisms: Recent developments and future prospects

R. H. Clayton^*, M. J. Bishop

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

10 Citations (Scopus)

Abstract

Ventricular arrhythmias are an important cause of death, and can also be a serious side effect of drugs. Computational models are becoming established as important research tools, alongside experimental work, for understanding the mechanisms that initiate and sustain these dangerous events. Advances in computer power have enabled large-scale simulations of cell and tissue electrophysiology, and advances in imaging have generated detailed models of cardiac anatomy. Active research areas include action potential propagation around an infarct, detailed modelling of drug effects in multi-scale models, low-voltage defibrillation and pipelines to establish patient-specific models of structure and function. Although computational power remains a bottleneck for high throughput simulations, it is probable that electrophysiological models will continue to become increasingly important tools.

Original language	English
Pages (from-to)	17-22
Number of pages	6
Journal	Drug Discovery Today: Disease Models
Volume	14
DOIs	https://doi.org/10.1016/j.ddmod.2014.04.002
Publication status	Published - 4 Feb 2014

Access to Document

10.1016/j.ddmod.2014.04.002

Cite this

@article{8cfe986de5be4d22bb0edb84ab4b5295,

title = "Computational models of ventricular arrhythmia mechanisms: Recent developments and future prospects",

abstract = "Ventricular arrhythmias are an important cause of death, and can also be a serious side effect of drugs. Computational models are becoming established as important research tools, alongside experimental work, for understanding the mechanisms that initiate and sustain these dangerous events. Advances in computer power have enabled large-scale simulations of cell and tissue electrophysiology, and advances in imaging have generated detailed models of cardiac anatomy. Active research areas include action potential propagation around an infarct, detailed modelling of drug effects in multi-scale models, low-voltage defibrillation and pipelines to establish patient-specific models of structure and function. Although computational power remains a bottleneck for high throughput simulations, it is probable that electrophysiological models will continue to become increasingly important tools.",

author = "Clayton, {R. H.} and Bishop, {M. J.}",

year = "2014",

month = feb,

day = "4",

doi = "10.1016/j.ddmod.2014.04.002",

language = "English",

volume = "14",

pages = "17--22",

journal = "Drug Discovery Today: Disease Models",

issn = "1740-6757",

publisher = "Elsevier Ltd",

}

TY - JOUR

T1 - Computational models of ventricular arrhythmia mechanisms

T2 - Recent developments and future prospects

AU - Clayton, R. H.

AU - Bishop, M. J.

PY - 2014/2/4

Y1 - 2014/2/4

N2 - Ventricular arrhythmias are an important cause of death, and can also be a serious side effect of drugs. Computational models are becoming established as important research tools, alongside experimental work, for understanding the mechanisms that initiate and sustain these dangerous events. Advances in computer power have enabled large-scale simulations of cell and tissue electrophysiology, and advances in imaging have generated detailed models of cardiac anatomy. Active research areas include action potential propagation around an infarct, detailed modelling of drug effects in multi-scale models, low-voltage defibrillation and pipelines to establish patient-specific models of structure and function. Although computational power remains a bottleneck for high throughput simulations, it is probable that electrophysiological models will continue to become increasingly important tools.

AB - Ventricular arrhythmias are an important cause of death, and can also be a serious side effect of drugs. Computational models are becoming established as important research tools, alongside experimental work, for understanding the mechanisms that initiate and sustain these dangerous events. Advances in computer power have enabled large-scale simulations of cell and tissue electrophysiology, and advances in imaging have generated detailed models of cardiac anatomy. Active research areas include action potential propagation around an infarct, detailed modelling of drug effects in multi-scale models, low-voltage defibrillation and pipelines to establish patient-specific models of structure and function. Although computational power remains a bottleneck for high throughput simulations, it is probable that electrophysiological models will continue to become increasingly important tools.

UR - http://www.scopus.com/inward/record.url?scp=84947491107&partnerID=8YFLogxK

U2 - 10.1016/j.ddmod.2014.04.002

DO - 10.1016/j.ddmod.2014.04.002

M3 - Review article

AN - SCOPUS:84947491107

SN - 1740-6757

VL - 14

SP - 17

EP - 22

JO - Drug Discovery Today: Disease Models

JF - Drug Discovery Today: Disease Models

ER -

Computational models of ventricular arrhythmia mechanisms: Recent developments and future prospects

Abstract

Access to Document

Other files and links

Fingerprint

Cite this