Computerized cognitive remediation training for schizophrenia:: An open label, multi-site, multinational methodology study

N. V. Murthy; H. Mahncke; B. E. Wexler; P. Maruff; A. Inamdar; M. Zucchetto; J. Lund; S. Shabbir; Sukhwinder Shergill; M. Keshavan; S. Kapur; M. Laruelle; R. Alexander

doi:10.1016/j.schres.2012.01.042

Computerized cognitive remediation training for schizophrenia: An open label, multi-site, multinational methodology study

N. V. Murthy, H. Mahncke, B. E. Wexler, P. Maruff, A. Inamdar, M. Zucchetto, J. Lund, S. Shabbir, Sukhwinder Shergill, M. Keshavan, S. Kapur, M. Laruelle, R. Alexander

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71 Citations (Scopus)

Abstract

A recent single-site study (Fisher et al., 2009. Am J Psychiatry. 166 (7) 805-11) showed that repeated training with the Brain Fitness Program (BFP) improved performance on a battery of neuropsychological tasks. If replicated these data suggest an important non-pharmacological method for ameliorating cognitive impairment in schizophrenia. Our study evaluated the BFP training effects in an open-label, multi-site, multinational clinical trial. Fifty-five stable adult patients with schizophrenia on regular antipsychotic medication completed >= 32 BFP training sessions over 8-10 weeks. Training effects on cognitive performance and functional capacity outcome measures were measured using CogState (R) schizophrenia battery, UCSD Performance based Skills Assessment (UPSA-2) and Cognitive Assessment Interview (CAI). BFP training showed a large and significant treatment effect on a training exercise task (auditory processing speed), however this effect did not generalize to improved performance on independent CogState (R) assessment. There were no significant effects on UPSA-2 or CAI scores. Our study demonstrated the feasibility of implementing BFP training in a multi-site study. However, BFP training did not show significant treatment effects on cognitive performance or functional capacity outcome measures despite showing large and significant effects on a training exercise. (C) 2012 Elsevier B.V. All rights reserved.

Original language	English
Pages (from-to)	87-91
Number of pages	5
Journal	Schizophrenia Research
Volume	139
Issue number	1-3
DOIs	https://doi.org/10.1016/j.schres.2012.01.042
Publication status	Published - Aug 2012

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Murthy, N. V., Mahncke, H., Wexler, B. E., Maruff, P., Inamdar, A., Zucchetto, M., Lund, J., Shabbir, S., Shergill, S., Keshavan, M., Kapur, S., Laruelle, M., & Alexander, R. (2012). Computerized cognitive remediation training for schizophrenia: An open label, multi-site, multinational methodology study. Schizophrenia Research, 139(1-3), 87-91. https://doi.org/10.1016/j.schres.2012.01.042

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title = "Computerized cognitive remediation training for schizophrenia:: An open label, multi-site, multinational methodology study",

abstract = "A recent single-site study (Fisher et al., 2009. Am J Psychiatry. 166 (7) 805-11) showed that repeated training with the Brain Fitness Program (BFP) improved performance on a battery of neuropsychological tasks. If replicated these data suggest an important non-pharmacological method for ameliorating cognitive impairment in schizophrenia. Our study evaluated the BFP training effects in an open-label, multi-site, multinational clinical trial. Fifty-five stable adult patients with schizophrenia on regular antipsychotic medication completed >= 32 BFP training sessions over 8-10 weeks. Training effects on cognitive performance and functional capacity outcome measures were measured using CogState (R) schizophrenia battery, UCSD Performance based Skills Assessment (UPSA-2) and Cognitive Assessment Interview (CAI). BFP training showed a large and significant treatment effect on a training exercise task (auditory processing speed), however this effect did not generalize to improved performance on independent CogState (R) assessment. There were no significant effects on UPSA-2 or CAI scores. Our study demonstrated the feasibility of implementing BFP training in a multi-site study. However, BFP training did not show significant treatment effects on cognitive performance or functional capacity outcome measures despite showing large and significant effects on a training exercise. (C) 2012 Elsevier B.V. All rights reserved.",

author = "Murthy, {N. V.} and H. Mahncke and Wexler, {B. E.} and P. Maruff and A. Inamdar and M. Zucchetto and J. Lund and S. Shabbir and Sukhwinder Shergill and M. Keshavan and S. Kapur and M. Laruelle and R. Alexander",

year = "2012",

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doi = "10.1016/j.schres.2012.01.042",

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Murthy, NV, Mahncke, H, Wexler, BE, Maruff, P, Inamdar, A, Zucchetto, M, Lund, J, Shabbir, S, Shergill, S, Keshavan, M, Kapur, S, Laruelle, M & Alexander, R 2012, 'Computerized cognitive remediation training for schizophrenia: An open label, multi-site, multinational methodology study', Schizophrenia Research, vol. 139, no. 1-3, pp. 87-91. https://doi.org/10.1016/j.schres.2012.01.042

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T1 - Computerized cognitive remediation training for schizophrenia:

T2 - An open label, multi-site, multinational methodology study

AU - Murthy, N. V.

AU - Mahncke, H.

AU - Wexler, B. E.

AU - Maruff, P.

AU - Inamdar, A.

AU - Zucchetto, M.

AU - Lund, J.

AU - Shabbir, S.

AU - Shergill, Sukhwinder

AU - Keshavan, M.

AU - Kapur, S.

AU - Laruelle, M.

AU - Alexander, R.

PY - 2012/8

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N2 - A recent single-site study (Fisher et al., 2009. Am J Psychiatry. 166 (7) 805-11) showed that repeated training with the Brain Fitness Program (BFP) improved performance on a battery of neuropsychological tasks. If replicated these data suggest an important non-pharmacological method for ameliorating cognitive impairment in schizophrenia. Our study evaluated the BFP training effects in an open-label, multi-site, multinational clinical trial. Fifty-five stable adult patients with schizophrenia on regular antipsychotic medication completed >= 32 BFP training sessions over 8-10 weeks. Training effects on cognitive performance and functional capacity outcome measures were measured using CogState (R) schizophrenia battery, UCSD Performance based Skills Assessment (UPSA-2) and Cognitive Assessment Interview (CAI). BFP training showed a large and significant treatment effect on a training exercise task (auditory processing speed), however this effect did not generalize to improved performance on independent CogState (R) assessment. There were no significant effects on UPSA-2 or CAI scores. Our study demonstrated the feasibility of implementing BFP training in a multi-site study. However, BFP training did not show significant treatment effects on cognitive performance or functional capacity outcome measures despite showing large and significant effects on a training exercise. (C) 2012 Elsevier B.V. All rights reserved.

AB - A recent single-site study (Fisher et al., 2009. Am J Psychiatry. 166 (7) 805-11) showed that repeated training with the Brain Fitness Program (BFP) improved performance on a battery of neuropsychological tasks. If replicated these data suggest an important non-pharmacological method for ameliorating cognitive impairment in schizophrenia. Our study evaluated the BFP training effects in an open-label, multi-site, multinational clinical trial. Fifty-five stable adult patients with schizophrenia on regular antipsychotic medication completed >= 32 BFP training sessions over 8-10 weeks. Training effects on cognitive performance and functional capacity outcome measures were measured using CogState (R) schizophrenia battery, UCSD Performance based Skills Assessment (UPSA-2) and Cognitive Assessment Interview (CAI). BFP training showed a large and significant treatment effect on a training exercise task (auditory processing speed), however this effect did not generalize to improved performance on independent CogState (R) assessment. There were no significant effects on UPSA-2 or CAI scores. Our study demonstrated the feasibility of implementing BFP training in a multi-site study. However, BFP training did not show significant treatment effects on cognitive performance or functional capacity outcome measures despite showing large and significant effects on a training exercise. (C) 2012 Elsevier B.V. All rights reserved.

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DO - 10.1016/j.schres.2012.01.042

M3 - Article

SN - 0920-9964

VL - 139

SP - 87

EP - 91

JO - Schizophrenia Research

JF - Schizophrenia Research

IS - 1-3

ER -

Computerized cognitive remediation training for schizophrenia: An open label, multi-site, multinational methodology study

Abstract

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