TY - JOUR
T1 - Computerized cognitive remediation training for schizophrenia:
T2 - An open label, multi-site, multinational methodology study
AU - Murthy, N. V.
AU - Mahncke, H.
AU - Wexler, B. E.
AU - Maruff, P.
AU - Inamdar, A.
AU - Zucchetto, M.
AU - Lund, J.
AU - Shabbir, S.
AU - Shergill, Sukhwinder
AU - Keshavan, M.
AU - Kapur, S.
AU - Laruelle, M.
AU - Alexander, R.
PY - 2012/8
Y1 - 2012/8
N2 - A recent single-site study (Fisher et al., 2009. Am J Psychiatry. 166 (7) 805-11) showed that repeated training with the Brain Fitness Program (BFP) improved performance on a battery of neuropsychological tasks. If replicated these data suggest an important non-pharmacological method for ameliorating cognitive impairment in schizophrenia. Our study evaluated the BFP training effects in an open-label, multi-site, multinational clinical trial. Fifty-five stable adult patients with schizophrenia on regular antipsychotic medication completed >= 32 BFP training sessions over 8-10 weeks. Training effects on cognitive performance and functional capacity outcome measures were measured using CogState (R) schizophrenia battery, UCSD Performance based Skills Assessment (UPSA-2) and Cognitive Assessment Interview (CAI). BFP training showed a large and significant treatment effect on a training exercise task (auditory processing speed), however this effect did not generalize to improved performance on independent CogState (R) assessment. There were no significant effects on UPSA-2 or CAI scores. Our study demonstrated the feasibility of implementing BFP training in a multi-site study. However, BFP training did not show significant treatment effects on cognitive performance or functional capacity outcome measures despite showing large and significant effects on a training exercise. (C) 2012 Elsevier B.V. All rights reserved.
AB - A recent single-site study (Fisher et al., 2009. Am J Psychiatry. 166 (7) 805-11) showed that repeated training with the Brain Fitness Program (BFP) improved performance on a battery of neuropsychological tasks. If replicated these data suggest an important non-pharmacological method for ameliorating cognitive impairment in schizophrenia. Our study evaluated the BFP training effects in an open-label, multi-site, multinational clinical trial. Fifty-five stable adult patients with schizophrenia on regular antipsychotic medication completed >= 32 BFP training sessions over 8-10 weeks. Training effects on cognitive performance and functional capacity outcome measures were measured using CogState (R) schizophrenia battery, UCSD Performance based Skills Assessment (UPSA-2) and Cognitive Assessment Interview (CAI). BFP training showed a large and significant treatment effect on a training exercise task (auditory processing speed), however this effect did not generalize to improved performance on independent CogState (R) assessment. There were no significant effects on UPSA-2 or CAI scores. Our study demonstrated the feasibility of implementing BFP training in a multi-site study. However, BFP training did not show significant treatment effects on cognitive performance or functional capacity outcome measures despite showing large and significant effects on a training exercise. (C) 2012 Elsevier B.V. All rights reserved.
U2 - 10.1016/j.schres.2012.01.042
DO - 10.1016/j.schres.2012.01.042
M3 - Article
SN - 0920-9964
VL - 139
SP - 87
EP - 91
JO - Schizophrenia Research
JF - Schizophrenia Research
IS - 1-3
ER -