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Conclusions on ventilator-induced mechanical injuries associated with ventilation using abnormally large tidal volume

Research output: Contribution to journalLetter

Original languageEnglish
Pages (from-to)736
Number of pages1
Issue number3
Published16 Feb 2016

King's Authors


I have read with interest the study of lung inhomogeneities and time course of ventilator-induced mechanical injuries, recently published in Anesthesiology by Cressoni et al.1
This study aimed at investigating the genesis of ventilator-induced lung injury in healthy piglets, with particular attention to the interface between inhomogeneous lung structures, and at determining whether the induced lung injury was associated with collapse or consolidation.
In 6 of the 12 animals considered, approximately 7.5% of the total lung volume had abnormal density on computed tomography scan, indicating consolidated tissue, and affecting respiratory system elastance. It is interesting that, if computed tomography scanning had not been performed, this potentially important abnormality could have been neglected. This is an important factor in the study of animals that are presumed healthy, but where health status is often overlooked, possibly affecting the results and conclusions of the studies...

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