Conduct Disorder and ADHD: Evaluation of Conduct Problems as a Categorical and Quantitative Trait in the International Multicentre ADHD Genetics Study

Richard J. L. Anney; Jessica Lasky-Su; Colm O'Dushlaine; Elaine Kenny; Benjamin M. Neale; Aisling Mulligan; Barbara Franke; Kaixin Zhou; Wai Chen; Hanna Christiansen; Alejandro Arias-Vasquez; Tobias Banaschewski; Jan Buitelaar; Richard Ebstein; Ana Miranda; Fernando Mulas; Robert D. Oades; Herbert Roeyers; Aribert Rothenberger; Joseph Sergeant; Edmund Sonuga-Barke; Hans Steinhausen; Philip Asherson; Stephen V. Faraone; Michael Gill

doi:10.1002/ajmg.b.30871

Conduct Disorder and ADHD: Evaluation of Conduct Problems as a Categorical and Quantitative Trait in the International Multicentre ADHD Genetics Study

Richard J. L. Anney, Jessica Lasky-Su, Colm O'Dushlaine, Elaine Kenny, Benjamin M. Neale, Aisling Mulligan, Barbara Franke, Kaixin Zhou, Wai Chen, Hanna Christiansen, Alejandro Arias-Vasquez, Tobias Banaschewski, Jan Buitelaar, Richard Ebstein, Ana Miranda, Fernando Mulas, Robert D. Oades, Herbert Roeyers, Aribert Rothenberger, Joseph SergeantEdmund Sonuga-Barke, Hans Steinhausen, Philip Asherson, Stephen V. Faraone, Michael Gill

Research output: Contribution to journal › Article › peer-review

103 Citations (Scopus)

Abstract

Attention-deficit/hyperactivity disorder (ADHD) is typically characterized by inattention, excessive motor activity, impulsivity, and distractibility. Individuals with ADHD have significant impairment in family and peer relations, academic functioning, and show high co-morbidity with a wide range of psychiatric disorders including oppositional defiant disorder (ODD), conduct disorder (CD), anxiety disorder, depression, substance abuse, and pervasive developmental disorder (PDD). Family studies suggest that ADHD + CD represents a specific subtype of the ADRD disorder with familial risk factors only partly overlapping with those of ADHD alone. We performed a hypothesis-free analysis of the GAIN-ADHD sample to identify markers and genes important in the development of conduct problems in a European cohort of individuals with ADHD. Using the Family-Based Association Test (FBAT) package we examined three measures of conduct problems in 1,043,963 antosomal markers. This study is part of a series of exploratory analyses to identify candidate genes that maybe important in ADHD and ADHD-related traits, such as conduct problems. We did not find genome-wide statistical significance (P <5 x 10(7)) for any of the tested markers and the three conduct problem traits. Fifty-four markers reached strong GWA signals (P <10(-5)). We discuss these findings in the context of putative candidate genes and the implications of these findings in the understanding of the etiology of ADHD + CD. We aimed to achieve insight into the genetic etiology of a trait using a hypothesis-free study design and were able to identify a number of biologically interesting markers and genes for follow-up studies. (c) 2008 Wiley-Liss, Inc.

Original language	English
Pages (from-to)	1369 - 1378
Number of pages	10
Journal	American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics
Volume	147B
Issue number	8
DOIs	https://doi.org/10.1002/ajmg.b.30871
Publication status	Published - 5 Dec 2008

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Anney, R. J. L., Lasky-Su, J., O'Dushlaine, C., Kenny, E., Neale, B. M., Mulligan, A., Franke, B., Zhou, K., Chen, W., Christiansen, H., Arias-Vasquez, A., Banaschewski, T., Buitelaar, J., Ebstein, R., Miranda, A., Mulas, F., Oades, R. D., Roeyers, H., Rothenberger, A., ... Gill, M. (2008). Conduct Disorder and ADHD: Evaluation of Conduct Problems as a Categorical and Quantitative Trait in the International Multicentre ADHD Genetics Study. American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics, 147B(8), 1369 - 1378. https://doi.org/10.1002/ajmg.b.30871

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title = "Conduct Disorder and ADHD: Evaluation of Conduct Problems as a Categorical and Quantitative Trait in the International Multicentre ADHD Genetics Study",

abstract = "Attention-deficit/hyperactivity disorder (ADHD) is typically characterized by inattention, excessive motor activity, impulsivity, and distractibility. Individuals with ADHD have significant impairment in family and peer relations, academic functioning, and show high co-morbidity with a wide range of psychiatric disorders including oppositional defiant disorder (ODD), conduct disorder (CD), anxiety disorder, depression, substance abuse, and pervasive developmental disorder (PDD). Family studies suggest that ADHD + CD represents a specific subtype of the ADRD disorder with familial risk factors only partly overlapping with those of ADHD alone. We performed a hypothesis-free analysis of the GAIN-ADHD sample to identify markers and genes important in the development of conduct problems in a European cohort of individuals with ADHD. Using the Family-Based Association Test (FBAT) package we examined three measures of conduct problems in 1,043,963 antosomal markers. This study is part of a series of exploratory analyses to identify candidate genes that maybe important in ADHD and ADHD-related traits, such as conduct problems. We did not find genome-wide statistical significance (P <5 x 10(7)) for any of the tested markers and the three conduct problem traits. Fifty-four markers reached strong GWA signals (P <10(-5)). We discuss these findings in the context of putative candidate genes and the implications of these findings in the understanding of the etiology of ADHD + CD. We aimed to achieve insight into the genetic etiology of a trait using a hypothesis-free study design and were able to identify a number of biologically interesting markers and genes for follow-up studies. (c) 2008 Wiley-Liss, Inc.",

author = "Anney, {Richard J. L.} and Jessica Lasky-Su and Colm O'Dushlaine and Elaine Kenny and Neale, {Benjamin M.} and Aisling Mulligan and Barbara Franke and Kaixin Zhou and Wai Chen and Hanna Christiansen and Alejandro Arias-Vasquez and Tobias Banaschewski and Jan Buitelaar and Richard Ebstein and Ana Miranda and Fernando Mulas and Oades, {Robert D.} and Herbert Roeyers and Aribert Rothenberger and Joseph Sergeant and Edmund Sonuga-Barke and Hans Steinhausen and Philip Asherson and Faraone, {Stephen V.} and Michael Gill",

year = "2008",

month = dec,

day = "5",

doi = "10.1002/ajmg.b.30871",

language = "English",

volume = "147B",

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journal = "American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics",

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Anney, RJL, Lasky-Su, J, O'Dushlaine, C, Kenny, E, Neale, BM, Mulligan, A, Franke, B, Zhou, K, Chen, W, Christiansen, H, Arias-Vasquez, A, Banaschewski, T, Buitelaar, J, Ebstein, R, Miranda, A, Mulas, F, Oades, RD, Roeyers, H, Rothenberger, A, Sergeant, J, Sonuga-Barke, E, Steinhausen, H, Asherson, P, Faraone, SV & Gill, M 2008, 'Conduct Disorder and ADHD: Evaluation of Conduct Problems as a Categorical and Quantitative Trait in the International Multicentre ADHD Genetics Study', American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics, vol. 147B, no. 8, pp. 1369 - 1378. https://doi.org/10.1002/ajmg.b.30871

Conduct Disorder and ADHD: Evaluation of Conduct Problems as a Categorical and Quantitative Trait in the International Multicentre ADHD Genetics Study. / Anney, Richard J. L.; Lasky-Su, Jessica; O'Dushlaine, Colm et al.
In: American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics, Vol. 147B, No. 8, 05.12.2008, p. 1369 - 1378.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Conduct Disorder and ADHD: Evaluation of Conduct Problems as a Categorical and Quantitative Trait in the International Multicentre ADHD Genetics Study

AU - Anney, Richard J. L.

AU - Lasky-Su, Jessica

AU - O'Dushlaine, Colm

AU - Kenny, Elaine

AU - Neale, Benjamin M.

AU - Mulligan, Aisling

AU - Franke, Barbara

AU - Zhou, Kaixin

AU - Chen, Wai

AU - Christiansen, Hanna

AU - Arias-Vasquez, Alejandro

AU - Banaschewski, Tobias

AU - Buitelaar, Jan

AU - Ebstein, Richard

AU - Miranda, Ana

AU - Mulas, Fernando

AU - Oades, Robert D.

AU - Roeyers, Herbert

AU - Rothenberger, Aribert

AU - Sergeant, Joseph

AU - Sonuga-Barke, Edmund

AU - Steinhausen, Hans

AU - Asherson, Philip

AU - Faraone, Stephen V.

AU - Gill, Michael

PY - 2008/12/5

Y1 - 2008/12/5

N2 - Attention-deficit/hyperactivity disorder (ADHD) is typically characterized by inattention, excessive motor activity, impulsivity, and distractibility. Individuals with ADHD have significant impairment in family and peer relations, academic functioning, and show high co-morbidity with a wide range of psychiatric disorders including oppositional defiant disorder (ODD), conduct disorder (CD), anxiety disorder, depression, substance abuse, and pervasive developmental disorder (PDD). Family studies suggest that ADHD + CD represents a specific subtype of the ADRD disorder with familial risk factors only partly overlapping with those of ADHD alone. We performed a hypothesis-free analysis of the GAIN-ADHD sample to identify markers and genes important in the development of conduct problems in a European cohort of individuals with ADHD. Using the Family-Based Association Test (FBAT) package we examined three measures of conduct problems in 1,043,963 antosomal markers. This study is part of a series of exploratory analyses to identify candidate genes that maybe important in ADHD and ADHD-related traits, such as conduct problems. We did not find genome-wide statistical significance (P <5 x 10(7)) for any of the tested markers and the three conduct problem traits. Fifty-four markers reached strong GWA signals (P <10(-5)). We discuss these findings in the context of putative candidate genes and the implications of these findings in the understanding of the etiology of ADHD + CD. We aimed to achieve insight into the genetic etiology of a trait using a hypothesis-free study design and were able to identify a number of biologically interesting markers and genes for follow-up studies. (c) 2008 Wiley-Liss, Inc.

AB - Attention-deficit/hyperactivity disorder (ADHD) is typically characterized by inattention, excessive motor activity, impulsivity, and distractibility. Individuals with ADHD have significant impairment in family and peer relations, academic functioning, and show high co-morbidity with a wide range of psychiatric disorders including oppositional defiant disorder (ODD), conduct disorder (CD), anxiety disorder, depression, substance abuse, and pervasive developmental disorder (PDD). Family studies suggest that ADHD + CD represents a specific subtype of the ADRD disorder with familial risk factors only partly overlapping with those of ADHD alone. We performed a hypothesis-free analysis of the GAIN-ADHD sample to identify markers and genes important in the development of conduct problems in a European cohort of individuals with ADHD. Using the Family-Based Association Test (FBAT) package we examined three measures of conduct problems in 1,043,963 antosomal markers. This study is part of a series of exploratory analyses to identify candidate genes that maybe important in ADHD and ADHD-related traits, such as conduct problems. We did not find genome-wide statistical significance (P <5 x 10(7)) for any of the tested markers and the three conduct problem traits. Fifty-four markers reached strong GWA signals (P <10(-5)). We discuss these findings in the context of putative candidate genes and the implications of these findings in the understanding of the etiology of ADHD + CD. We aimed to achieve insight into the genetic etiology of a trait using a hypothesis-free study design and were able to identify a number of biologically interesting markers and genes for follow-up studies. (c) 2008 Wiley-Liss, Inc.

U2 - 10.1002/ajmg.b.30871

DO - 10.1002/ajmg.b.30871

M3 - Article

SN - 1552-485X

VL - 147B

SP - 1369

EP - 1378

JO - American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics

JF - American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics

IS - 8

ER -

Conduct Disorder and ADHD: Evaluation of Conduct Problems as a Categorical and Quantitative Trait in the International Multicentre ADHD Genetics Study

Abstract

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