Conflicting MRI signals from gliosis and neuronal vacuolation in prion diseases

TY - JOUR

T1 - Conflicting MRI signals from gliosis and neuronal vacuolation in prion diseases

AU - Chung, Y L

AU - Williams, A

AU - Ritchie, D

AU - Williams, Steven

AU - Changani, K K

AU - Hope, J

AU - Bell, J D

PY - 1999/11/26

Y1 - 1999/11/26

N2 - MAGNETIC resonance imaging (MRI) has given inconsistent results when used as a non-invasive diagnostic tool for Creutzfeldt-Jakob disease (CJD). In order to understand this finding, we studied a hamster model of scrapie by in vivo MRI and histopathology. Vacuolation of neurones/neuropil and gliosis were found to correlate with hypo-intense and hyper-intense changes in the conventional T2-weighted MR images, respectively. These opposing effects were shown to give rise to normal images of a scrapie-affected brain undergoing severe neurodegeneration, and may underlie the variability of previous CJD MRI data. (C) 1999 Lippincott Williams & Wilkins.

AB - MAGNETIC resonance imaging (MRI) has given inconsistent results when used as a non-invasive diagnostic tool for Creutzfeldt-Jakob disease (CJD). In order to understand this finding, we studied a hamster model of scrapie by in vivo MRI and histopathology. Vacuolation of neurones/neuropil and gliosis were found to correlate with hypo-intense and hyper-intense changes in the conventional T2-weighted MR images, respectively. These opposing effects were shown to give rise to normal images of a scrapie-affected brain undergoing severe neurodegeneration, and may underlie the variability of previous CJD MRI data. (C) 1999 Lippincott Williams & Wilkins.

M3 - Article

SN - 0959-4965

VL - 10

SP - 3471

EP - 3477

JO - Neuroreport

JF - Neuroreport

IS - 17

ER -