Conformational changes and disease - Serpins, prions and Alzheimer's

TY - JOUR

T1 - Conformational changes and disease - Serpins, prions and Alzheimer's

AU - Carrell, R.W.

AU - Gooptu, Bibekbrata

PY - 1998/12

Y1 - 1998/12

N2 - Some of the most perplexing disorders in medicine are each now known to arise from the conformational instability of an underlying protein. The consequence is a continuum of pathologies with typically a change in fold leading to ordered aggregation and tissue deposition. The serpins provide a structural prototype for these pathologies and give a perspective on the assessment of current proposals as to the conformational basis of both Alzheimer's disease and the transmissible prion encephalopathies.

AB - Some of the most perplexing disorders in medicine are each now known to arise from the conformational instability of an underlying protein. The consequence is a continuum of pathologies with typically a change in fold leading to ordered aggregation and tissue deposition. The serpins provide a structural prototype for these pathologies and give a perspective on the assessment of current proposals as to the conformational basis of both Alzheimer's disease and the transmissible prion encephalopathies.

UR - http://www.scopus.com/inward/record.url?partnerID=yv4JPVwI&eid=2-s2.0-0032425463&md5=7dcf92117a6b1ad926b207fecd64d4ab

U2 - 10.1016/S0959-440X(98)80101-2

DO - 10.1016/S0959-440X(98)80101-2

M3 - Article

AN - SCOPUS:0032425463

SN - 0959-440X

VL - 8

SP - 799

EP - 809

JO - Current Opinion in Structural Biology

JF - Current Opinion in Structural Biology

IS - 6

ER -