Congenital tracheal defects: embryonic development and animal models

TY - JOUR

T1 - Congenital tracheal defects: embryonic development and animal models

AU - Sher, Zenab Arooj

AU - Liu, Karen Jasmine

PY - 2016/3/31

Y1 - 2016/3/31

N2 - Tracheal anomalies are potentially catastrophic congenital defects. As a newborn begins to breathe, the trachea needs to maintain an appropriate balance of elasticity and rigidity. If the tracheal cartilages are disorganized or structurally weak, the airways can collapse, obstructing breathing. Cartilage rings that are too small or too rigid can also obstruct breathing. These anomalies are frequently associated with craniofacial syndromes, and, despite the importance, are poorly understood. In this review, we summarize the spectrum of pathological phenotypes of the trachea and correlate them with the molecular events uncovered in mouse models.

AB - Tracheal anomalies are potentially catastrophic congenital defects. As a newborn begins to breathe, the trachea needs to maintain an appropriate balance of elasticity and rigidity. If the tracheal cartilages are disorganized or structurally weak, the airways can collapse, obstructing breathing. Cartilage rings that are too small or too rigid can also obstruct breathing. These anomalies are frequently associated with craniofacial syndromes, and, despite the importance, are poorly understood. In this review, we summarize the spectrum of pathological phenotypes of the trachea and correlate them with the molecular events uncovered in mouse models.

KW - trachea

KW - Congenital anomaly

KW - AIRWAY

U2 - 10.3934/genet.2016.1.60

DO - 10.3934/genet.2016.1.60

M3 - Article

SN - 2377-1143

VL - 3

JO - AIMS Genetics

JF - AIMS Genetics

IS - 1

ER -