King's College London

Research portal

Congenital tracheal defects: embryonic development and animal models

Research output: Contribution to journalArticlepeer-review

Zenab Arooj Sher, Karen Jasmine Liu

Original languageEnglish
JournalAIMS Genetics
Issue number1
Accepted/In press29 Mar 2016
Published31 Mar 2016


King's Authors


Tracheal anomalies are potentially catastrophic congenital defects. As a newborn begins to breathe, the trachea needs to maintain an appropriate balance of elasticity and rigidity. If the tracheal cartilages are disorganized or structurally weak, the airways can collapse, obstructing breathing. Cartilage rings that are too small or too rigid can also obstruct breathing. These anomalies are frequently associated with craniofacial syndromes, and, despite the importance, are poorly understood. In this review, we summarize the spectrum of pathological phenotypes of the trachea and correlate them with the molecular events uncovered in mouse models.

Download statistics

No data available

View graph of relations

© 2020 King's College London | Strand | London WC2R 2LS | England | United Kingdom | Tel +44 (0)20 7836 5454