Conjugated polymers as nanoparticle probes for fluorescence and photoacoustic imaging

Thais Fedatto Abelha; Cecile Ayako Dreiss; Mark Green; Lea Ann Dailey

doi:10.1039/C9TB02582K

Conjugated polymers as nanoparticle probes for fluorescence and photoacoustic imaging

Thais Fedatto Abelha, Cecile Ayako Dreiss, Mark Green, Lea Ann Dailey

Research output: Contribution to journal › Review article › peer-review

63 Citations (Scopus)

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Abstract

Bioimaging enables the visualisation of biological processes at the microscopic and macroscopic levels, finding applications from cellular tracking to whole body scanning for diagnosis purposes. The different techniques developed to acquire images make use of most radiation types of the electromagnetic spectrum. Recently, there has been interest in non-ionising radiation imaging techniques that can offer improved detection or additional information about biological processes, and fluorescence and photoacoustic imaging have become an eminent field. Conjugated polymers are versatile materials for bioimaging due to their tailored absorption and emission spectra and applications in both fluorescence and photoacoustic imaging. This review gives an overview on bioimaging techniques, with a special focus on conjugated polymer nanoparticles (CPNs), the different types of nanoparticle chemistries published and their preclinical safety assessment.

Original language	English
Pages (from-to)	592-606
Number of pages	15
Journal	Journal of materials chemistry b
Volume	8
Issue number	4
Early online date	6 Jan 2020
DOIs	https://doi.org/10.1039/C9TB02582K
Publication status	E-pub ahead of print - 6 Jan 2020

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Conjugated polymers as nanoparticle_ABELHA_Accepted26December2019_Epublished06January2020_AAMAccepted author manuscript, 628 KB

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AU - Dreiss, Cecile Ayako

AU - Green, Mark

AU - Dailey, Lea Ann

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AB - Bioimaging enables the visualisation of biological processes at the microscopic and macroscopic levels, finding applications from cellular tracking to whole body scanning for diagnosis purposes. The different techniques developed to acquire images make use of most radiation types of the electromagnetic spectrum. Recently, there has been interest in non-ionising radiation imaging techniques that can offer improved detection or additional information about biological processes, and fluorescence and photoacoustic imaging have become an eminent field. Conjugated polymers are versatile materials for bioimaging due to their tailored absorption and emission spectra and applications in both fluorescence and photoacoustic imaging. This review gives an overview on bioimaging techniques, with a special focus on conjugated polymer nanoparticles (CPNs), the different types of nanoparticle chemistries published and their preclinical safety assessment.

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Conjugated polymers as nanoparticle probes for fluorescence and photoacoustic imaging

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