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Conjugated polymers as nanoparticle probes for fluorescence and photoacoustic imaging

Research output: Contribution to journalReview article

Original languageEnglish
Pages (from-to)592-606
Number of pages15
JournalJournal of materials chemistry b
Volume8
Issue number4
Early online date6 Jan 2020
DOIs
Publication statusE-pub ahead of print - 6 Jan 2020

King's Authors

Abstract

Bioimaging enables the visualisation of biological processes at the microscopic and macroscopic levels, finding applications from cellular tracking to whole body scanning for diagnosis purposes. The different techniques developed to acquire images make use of most radiation types of the electromagnetic spectrum. Recently, there has been interest in non-ionising radiation imaging techniques that can offer improved detection or additional information about biological processes, and fluorescence and photoacoustic imaging have become an eminent field. Conjugated polymers are versatile materials for bioimaging due to their tailored absorption and emission spectra and applications in both fluorescence and photoacoustic imaging. This review gives an overview on bioimaging techniques, with a special focus on conjugated polymer nanoparticles (CPNs), the different types of nanoparticle chemistries published and their preclinical safety assessment.

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