Conjugation of vitamin e analog α-TOS to Pt(iv) complexes for dual-targeting anticancer therapy

Kogularamanan Suntharalingam; Ying Song; Stephen J. Lippard

doi:10.1039/c3cc48740g

Conjugation of vitamin e analog α-TOS to Pt(iv) complexes for dual-targeting anticancer therapy

Kogularamanan Suntharalingam, Ying Song, Stephen J. Lippard^*

^*Corresponding author for this work

Chemistry

Massachusetts Institute of Technology

Research output: Contribution to journal › Article › peer-review

101 Citations (Scopus)

Abstract

We report two platinum(iv) complexes conjugated with a vitamin E analog, α-tocopherol succinate (α-TOS). One of the conjugates displays the activity of both cisplatin and α-TOS in cancer cells, causing damage to DNA and mitochondria simultaneously. Accordingly, it serves as a promising dual-targeting anticancer agent.

Original language	English
Pages (from-to)	2465-2468
Number of pages	4
Journal	Chemical communications (Cambridge, England)
Volume	50
Issue number	19
DOIs	https://doi.org/10.1039/c3cc48740g
Publication status	Published - 7 Mar 2014

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abstract = "We report two platinum(iv) complexes conjugated with a vitamin E analog, α-tocopherol succinate (α-TOS). One of the conjugates displays the activity of both cisplatin and α-TOS in cancer cells, causing damage to DNA and mitochondria simultaneously. Accordingly, it serves as a promising dual-targeting anticancer agent.",

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AU - Lippard, Stephen J.

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AB - We report two platinum(iv) complexes conjugated with a vitamin E analog, α-tocopherol succinate (α-TOS). One of the conjugates displays the activity of both cisplatin and α-TOS in cancer cells, causing damage to DNA and mitochondria simultaneously. Accordingly, it serves as a promising dual-targeting anticancer agent.

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Conjugation of vitamin e analog α-TOS to Pt(iv) complexes for dual-targeting anticancer therapy

Abstract

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