Conjugation of vitamin e analog α-TOS to Pt(iv) complexes for dual-targeting anticancer therapy

TY - JOUR

T1 - Conjugation of vitamin e analog α-TOS to Pt(iv) complexes for dual-targeting anticancer therapy

AU - Suntharalingam, Kogularamanan

AU - Song, Ying

AU - Lippard, Stephen J.

PY - 2014/3/7

Y1 - 2014/3/7

N2 - We report two platinum(iv) complexes conjugated with a vitamin E analog, α-tocopherol succinate (α-TOS). One of the conjugates displays the activity of both cisplatin and α-TOS in cancer cells, causing damage to DNA and mitochondria simultaneously. Accordingly, it serves as a promising dual-targeting anticancer agent.

AB - We report two platinum(iv) complexes conjugated with a vitamin E analog, α-tocopherol succinate (α-TOS). One of the conjugates displays the activity of both cisplatin and α-TOS in cancer cells, causing damage to DNA and mitochondria simultaneously. Accordingly, it serves as a promising dual-targeting anticancer agent.

UR - https://www.scopus.com/pages/publications/84893833154

U2 - 10.1039/c3cc48740g

DO - 10.1039/c3cc48740g

M3 - Article

C2 - 24452361

AN - SCOPUS:84893833154

SN - 1359-7345

VL - 50

SP - 2465

EP - 2468

JO - Chemical communications (Cambridge, England)

JF - Chemical communications (Cambridge, England)

IS - 19

ER -