Connectome hubs at resting state in children and adolescents: reproducibility and psychopathological correlation

João Ricardo Sato; Claudinei Eduardo Biazoli Jr; Giovanni Abrahão Salum; Ary Gadelha; Nicolas Crossley; Gilson Vieira; André Zugman; Felipe Almeida Picon; Pedro Mario Pan; Marcelo Queiroz Hoexter; Mauricio Anés; Luciana Monteiro Moura; Marco Antonio Gomes Del ’Aquilla; Edson Amaro Junior; Philip Mcguire; Luis Augusto Rohde; Euripedes Constantino Miguel; Rodrigo Affonseca Bressan; Andrea Parolin Jackowski

doi:10.1016/j.dcn.2016.05.002

Connectome hubs at resting state in children and adolescents: reproducibility and psychopathological correlation

João Ricardo Sato, Claudinei Eduardo Biazoli Jr, Giovanni Abrahão Salum, Ary Gadelha, Nicolas Crossley, Gilson Vieira, André Zugman, Felipe Almeida Picon, Pedro Mario Pan, Marcelo Queiroz Hoexter, Mauricio Anés, Luciana Monteiro Moura, Marco Antonio Gomes Del ’Aquilla, Edson Amaro Junior, Philip Mcguire, Luis Augusto Rohde, Euripedes Constantino Miguel, Rodrigo Affonseca Bressan, Andrea Parolin Jackowski

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Abstract

Functional brain hubs are key integrative regions in brain networks. Recently, brain hubs identified through resting-state fMRI have emerged as interesting targets to increase understanding of the relationships between large-scale functional networks and psychopathology. However, few studies have directly addressed the replicability and consistency of the hub regions identified and their association with symptoms. Here, we used the eigenvector centrality (EVC) measure obtained from graph analysis of two large, independent population-based samples of children and adolescents (7 to 15 years old; total N = 652; 341 subjects for site 1 and 311 for site 2) to evaluate the replicability of hub identification. Subsequently, we tested the association between replicable hub regions and psychiatric symptoms. We identified a set of hubs consisting of the anterior medial prefrontal cortex and inferior parietal lobule/intraparietal sulcus (IPL/IPS). Moreover, lower EVC values in the right IPS were associated with psychiatric symptoms in both samples. Thus, low centrality of the IPS was a replicable sign of potential vulnerability to mental disorders in children. The identification of critical and replicable hubs in functional cortical networks in children and adolescents can foster understanding of the mechanisms underlying mental disorders.

Original language	English
Journal	Developmental Cognitive Neuroscience
Early online date	14 May 2016
DOIs	https://doi.org/10.1016/j.dcn.2016.05.002
Publication status	E-pub ahead of print - 14 May 2016

Keywords

resting state
replication
fMRI
connectivity
development
children

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Connectome hubs at resting state in children and adolescents reproducibility and psychopathological correlation AAM
© 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
Accepted author manuscript, 1.19 MBLicence: CC BY-NC-ND

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Sato, J. R., Jr, C. E. B., Salum, G. A., Gadelha, A., Crossley, N., Vieira, G., Zugman, A., Picon, F. A., Pan, P. M., Hoexter, M. Q., Anés, M., Moura, L. M., ’Aquilla, M. A. G. D., Junior, E. A., Mcguire, P., Rohde, L. A., Miguel, E. C., Bressan, R. A., & Jackowski, A. P. (2016). Connectome hubs at resting state in children and adolescents: reproducibility and psychopathological correlation. Developmental Cognitive Neuroscience. Advance online publication. https://doi.org/10.1016/j.dcn.2016.05.002

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title = "Connectome hubs at resting state in children and adolescents: reproducibility and psychopathological correlation",

abstract = "Functional brain hubs are key integrative regions in brain networks. Recently, brain hubs identified through resting-state fMRI have emerged as interesting targets to increase understanding of the relationships between large-scale functional networks and psychopathology. However, few studies have directly addressed the replicability and consistency of the hub regions identified and their association with symptoms. Here, we used the eigenvector centrality (EVC) measure obtained from graph analysis of two large, independent population-based samples of children and adolescents (7 to 15 years old; total N = 652; 341 subjects for site 1 and 311 for site 2) to evaluate the replicability of hub identification. Subsequently, we tested the association between replicable hub regions and psychiatric symptoms. We identified a set of hubs consisting of the anterior medial prefrontal cortex and inferior parietal lobule/intraparietal sulcus (IPL/IPS). Moreover, lower EVC values in the right IPS were associated with psychiatric symptoms in both samples. Thus, low centrality of the IPS was a replicable sign of potential vulnerability to mental disorders in children. The identification of critical and replicable hubs in functional cortical networks in children and adolescents can foster understanding of the mechanisms underlying mental disorders.",

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Sato, JR, Jr, CEB, Salum, GA, Gadelha, A, Crossley, N, Vieira, G, Zugman, A, Picon, FA, Pan, PM, Hoexter, MQ, Anés, M, Moura, LM, ’Aquilla, MAGD, Junior, EA, Mcguire, P, Rohde, LA, Miguel, EC, Bressan, RA & Jackowski, AP 2016, 'Connectome hubs at resting state in children and adolescents: reproducibility and psychopathological correlation', Developmental Cognitive Neuroscience. https://doi.org/10.1016/j.dcn.2016.05.002

TY - JOUR

T1 - Connectome hubs at resting state in children and adolescents

T2 - reproducibility and psychopathological correlation

AU - Sato, João Ricardo

AU - Jr, Claudinei Eduardo Biazoli

AU - Salum, Giovanni Abrahão

AU - Gadelha, Ary

AU - Crossley, Nicolas

AU - Vieira, Gilson

AU - Zugman, André

AU - Picon, Felipe Almeida

AU - Pan, Pedro Mario

AU - Hoexter, Marcelo Queiroz

AU - Anés, Mauricio

AU - Moura, Luciana Monteiro

AU - ’Aquilla, Marco Antonio Gomes Del

AU - Junior, Edson Amaro

AU - Mcguire, Philip

AU - Rohde, Luis Augusto

AU - Miguel, Euripedes Constantino

AU - Bressan, Rodrigo Affonseca

AU - Jackowski, Andrea Parolin

PY - 2016/5/14

Y1 - 2016/5/14

N2 - Functional brain hubs are key integrative regions in brain networks. Recently, brain hubs identified through resting-state fMRI have emerged as interesting targets to increase understanding of the relationships between large-scale functional networks and psychopathology. However, few studies have directly addressed the replicability and consistency of the hub regions identified and their association with symptoms. Here, we used the eigenvector centrality (EVC) measure obtained from graph analysis of two large, independent population-based samples of children and adolescents (7 to 15 years old; total N = 652; 341 subjects for site 1 and 311 for site 2) to evaluate the replicability of hub identification. Subsequently, we tested the association between replicable hub regions and psychiatric symptoms. We identified a set of hubs consisting of the anterior medial prefrontal cortex and inferior parietal lobule/intraparietal sulcus (IPL/IPS). Moreover, lower EVC values in the right IPS were associated with psychiatric symptoms in both samples. Thus, low centrality of the IPS was a replicable sign of potential vulnerability to mental disorders in children. The identification of critical and replicable hubs in functional cortical networks in children and adolescents can foster understanding of the mechanisms underlying mental disorders.

AB - Functional brain hubs are key integrative regions in brain networks. Recently, brain hubs identified through resting-state fMRI have emerged as interesting targets to increase understanding of the relationships between large-scale functional networks and psychopathology. However, few studies have directly addressed the replicability and consistency of the hub regions identified and their association with symptoms. Here, we used the eigenvector centrality (EVC) measure obtained from graph analysis of two large, independent population-based samples of children and adolescents (7 to 15 years old; total N = 652; 341 subjects for site 1 and 311 for site 2) to evaluate the replicability of hub identification. Subsequently, we tested the association between replicable hub regions and psychiatric symptoms. We identified a set of hubs consisting of the anterior medial prefrontal cortex and inferior parietal lobule/intraparietal sulcus (IPL/IPS). Moreover, lower EVC values in the right IPS were associated with psychiatric symptoms in both samples. Thus, low centrality of the IPS was a replicable sign of potential vulnerability to mental disorders in children. The identification of critical and replicable hubs in functional cortical networks in children and adolescents can foster understanding of the mechanisms underlying mental disorders.

KW - resting state

KW - replication

KW - fMRI

KW - connectivity

KW - development

KW - children

U2 - 10.1016/j.dcn.2016.05.002

DO - 10.1016/j.dcn.2016.05.002

M3 - Article

SN - 1878-9293

JO - Developmental Cognitive Neuroscience

JF - Developmental Cognitive Neuroscience

ER -

Connectome hubs at resting state in children and adolescents: reproducibility and psychopathological correlation

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Keywords

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