Consensus criteria for the diagnosis of frontotemporal cognitive and behavioural syndromes in amyotrophic lateral sclerosis

Michael J. Strong, Gloria M. Grace, Morris Freedman, Cathy Lomen-Hoerth, Susan Woolley, Laura H. Goldstein, Jennifer Murphy, Christen Shoesmith, Jeffery Rosenfeld, P. Nigel Leigh, Lucie Bruijn, Paul Ince, Denise Figlewicz

Research output: Contribution to journalLiterature reviewpeer-review

452 Citations (Scopus)

Abstract

Amyotrophic lateral sclerosis (ALS) is increasingly recognized to be a multisystem disorder which includes both clinical and neuropathological features of a frontotemporal lobar degeneration (FTLD). In order to provide a common framework within which to discuss the characteristics of the cognitive and behavioural syndromes of ALS, and with which to conduct clinical and neuropathological research, an international research workshop on frontotemporal dementia (FTD) and ALS was held in London, Canada in June 2007. The recommendations arising from this research workshop address the requirement for a concise clinical diagnosis of the underlying motor neuron disease (Axis I), defining the cognitive and behavioural dysfunction (Axis II), describing additional non-motor manifestations (Axis III) and identifying the presence of disease modifiers (Axis IV).
Original languageEnglish
Pages (from-to)131 - 146
Number of pages16
JournalAmyotrophic Lateral Sclerosis and Other Motor Neuron Disorders
Volume10
Issue number3
DOIs
Publication statusPublished - 2009

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