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Conséquences cérébrales à long terme de l'inflammation périnatale

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Conséquences cérébrales à long terme de l'inflammation périnatale. / Chhor, V; Schang, A-L; Favrais, G; Fleiss, B; Gressens, P.

In: Archives De Pediatrie, Vol. 19, No. 9, N/A, 09.2012, p. 946-952.

Research output: Contribution to journalArticle

Harvard

Chhor, V, Schang, A-L, Favrais, G, Fleiss, B & Gressens, P 2012, 'Conséquences cérébrales à long terme de l'inflammation périnatale', Archives De Pediatrie, vol. 19, no. 9, N/A, pp. 946-952. https://doi.org/10.1016/j.arcped.2012.06.013

APA

Chhor, V., Schang, A-L., Favrais, G., Fleiss, B., & Gressens, P. (2012). Conséquences cérébrales à long terme de l'inflammation périnatale. Archives De Pediatrie, 19(9), 946-952. [N/A]. https://doi.org/10.1016/j.arcped.2012.06.013

Vancouver

Chhor V, Schang A-L, Favrais G, Fleiss B, Gressens P. Conséquences cérébrales à long terme de l'inflammation périnatale. Archives De Pediatrie. 2012 Sep;19(9):946-952. N/A. https://doi.org/10.1016/j.arcped.2012.06.013

Author

Chhor, V ; Schang, A-L ; Favrais, G ; Fleiss, B ; Gressens, P. / Conséquences cérébrales à long terme de l'inflammation périnatale. In: Archives De Pediatrie. 2012 ; Vol. 19, No. 9. pp. 946-952.

Bibtex Download

@article{bd6e9a7ba8d040f2ac79dcc8ad82f231,
title = "Cons{\'e}quences c{\'e}r{\'e}brales {\`a} long terme de l'inflammation p{\'e}rinatale",
abstract = "Perinatal inflammation can lead to fetal/neonatal inflammatory syndrome, a risk factor for brain lesions, especially in the white matter. Perinatal inflammation is associated with increased incidence of cerebral palsy in humans and animal models and there is a strong relationship with increased incidence of autism and schizophrenia in humans. Perinatal inflammation causes acute microglial and astroglial activation, blood-brain barrier dysfunction, and disrupts oligodendrocyte maturation leading to hypomyelination. Inflammation also sensitizes the brain to additional perinatal insults, including hypoxia-ischemia. Furthermore, long after the primary cause of inflammation has resolved, gliosis may also persist and predispose to neurodegenerative diseases including Alzheimer's and Parkinson's disease, but this relation is still hypothetical. Finding of acute and chronic changes in brain structure and function due to perinatal inflammation highlights the need for treatments. As gliosis appears to be involved in the acute and chronic effects of perinatal inflammation, modulating the glial phenotype may be an effective strategy to prevent damage to the brain.",
keywords = "PROGRAMMED CELL-DEATH, MICROGLIAL ACTIVATION, BIRTH-WEIGHT INFANTS, TRAUMATIC BRAIN-INJURY, SYSTEMIC INFLAMMATION, IMMATURE BRAIN, HYPOXIA-ISCHEMIA, PRETERM, DEVELOPMENTAL REGULATION, WHITE-MATTER INJURY",
author = "V Chhor and A-L Schang and G Favrais and B Fleiss and P Gressens",
year = "2012",
month = "9",
doi = "10.1016/j.arcped.2012.06.013",
language = "French",
volume = "19",
pages = "946--952",
journal = "Archives De Pediatrie",
issn = "0929-693X",
publisher = "Elsevier Masson",
number = "9",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Conséquences cérébrales à long terme de l'inflammation périnatale

AU - Chhor, V

AU - Schang, A-L

AU - Favrais, G

AU - Fleiss, B

AU - Gressens, P

PY - 2012/9

Y1 - 2012/9

N2 - Perinatal inflammation can lead to fetal/neonatal inflammatory syndrome, a risk factor for brain lesions, especially in the white matter. Perinatal inflammation is associated with increased incidence of cerebral palsy in humans and animal models and there is a strong relationship with increased incidence of autism and schizophrenia in humans. Perinatal inflammation causes acute microglial and astroglial activation, blood-brain barrier dysfunction, and disrupts oligodendrocyte maturation leading to hypomyelination. Inflammation also sensitizes the brain to additional perinatal insults, including hypoxia-ischemia. Furthermore, long after the primary cause of inflammation has resolved, gliosis may also persist and predispose to neurodegenerative diseases including Alzheimer's and Parkinson's disease, but this relation is still hypothetical. Finding of acute and chronic changes in brain structure and function due to perinatal inflammation highlights the need for treatments. As gliosis appears to be involved in the acute and chronic effects of perinatal inflammation, modulating the glial phenotype may be an effective strategy to prevent damage to the brain.

AB - Perinatal inflammation can lead to fetal/neonatal inflammatory syndrome, a risk factor for brain lesions, especially in the white matter. Perinatal inflammation is associated with increased incidence of cerebral palsy in humans and animal models and there is a strong relationship with increased incidence of autism and schizophrenia in humans. Perinatal inflammation causes acute microglial and astroglial activation, blood-brain barrier dysfunction, and disrupts oligodendrocyte maturation leading to hypomyelination. Inflammation also sensitizes the brain to additional perinatal insults, including hypoxia-ischemia. Furthermore, long after the primary cause of inflammation has resolved, gliosis may also persist and predispose to neurodegenerative diseases including Alzheimer's and Parkinson's disease, but this relation is still hypothetical. Finding of acute and chronic changes in brain structure and function due to perinatal inflammation highlights the need for treatments. As gliosis appears to be involved in the acute and chronic effects of perinatal inflammation, modulating the glial phenotype may be an effective strategy to prevent damage to the brain.

KW - PROGRAMMED CELL-DEATH

KW - MICROGLIAL ACTIVATION

KW - BIRTH-WEIGHT INFANTS

KW - TRAUMATIC BRAIN-INJURY

KW - SYSTEMIC INFLAMMATION

KW - IMMATURE BRAIN

KW - HYPOXIA-ISCHEMIA

KW - PRETERM

KW - DEVELOPMENTAL REGULATION

KW - WHITE-MATTER INJURY

U2 - 10.1016/j.arcped.2012.06.013

DO - 10.1016/j.arcped.2012.06.013

M3 - Article

C2 - 22885003

VL - 19

SP - 946

EP - 952

JO - Archives De Pediatrie

JF - Archives De Pediatrie

SN - 0929-693X

IS - 9

M1 - N/A

ER -

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