TY - JOUR
T1 - Consequences of the expression of sialylated antigens in breast cancer
AU - Cazet, Aurelie
AU - Julien, Sylvain
AU - Bobowski, Marie
AU - Krzewinski-Recchi, Marie-Ange
AU - Harduin-Lepers, Anne
AU - Groux-Degroote, Sophie
AU - Delannoy, Philippe
PY - 2010/7/2
Y1 - 2010/7/2
N2 - Changes in cell surface glycosylation are common modifications that occur during oncogenesis, leading to the over-expression of tumour-associated carbohydrate antigens (TACA). Most of these antigens are sialylated and the increase of sialylation is a well-known feature of transformed cells. In breast cancer, expression of TACA such as sialyl-Lewis(x) or sialyl-Tn is usually associated with a poor prognosis and a decreased overall survival of patients. However, the specific role of these sialylated antigens in breast tumour development and aggressiveness is not clearly understood. These glycosylation changes result from the modification of the expression of genes encoding specific glycosyltransferases involved in glycan biosynthesis and the level of expression of sialyltransferase genes has been proposed to be a prognostic marker for the follow-up of breast cancer patients. Several human cellular models have been developed in order to explain the mechanisms by which carbohydrate antigens can reinforce breast cancer progression and aggressiveness. TACA expression is associated with changes in cell adhesion, migration, proliferation and tumour growth. In addition, recent data on glycolipid biosynthesis indicate an important role of G(D3) synthase expression in breast cancer progression. The aim of this review is to summarize our current knowledge of sialylation changes that occur in breast cancer and to describe the cellular models developed to analyze the consequences of these changes on disease progression and aggressiveness. (C) 2010 Elsevier Ltd. All rights reserved.
AB - Changes in cell surface glycosylation are common modifications that occur during oncogenesis, leading to the over-expression of tumour-associated carbohydrate antigens (TACA). Most of these antigens are sialylated and the increase of sialylation is a well-known feature of transformed cells. In breast cancer, expression of TACA such as sialyl-Lewis(x) or sialyl-Tn is usually associated with a poor prognosis and a decreased overall survival of patients. However, the specific role of these sialylated antigens in breast tumour development and aggressiveness is not clearly understood. These glycosylation changes result from the modification of the expression of genes encoding specific glycosyltransferases involved in glycan biosynthesis and the level of expression of sialyltransferase genes has been proposed to be a prognostic marker for the follow-up of breast cancer patients. Several human cellular models have been developed in order to explain the mechanisms by which carbohydrate antigens can reinforce breast cancer progression and aggressiveness. TACA expression is associated with changes in cell adhesion, migration, proliferation and tumour growth. In addition, recent data on glycolipid biosynthesis indicate an important role of G(D3) synthase expression in breast cancer progression. The aim of this review is to summarize our current knowledge of sialylation changes that occur in breast cancer and to describe the cellular models developed to analyze the consequences of these changes on disease progression and aggressiveness. (C) 2010 Elsevier Ltd. All rights reserved.
UR - http://www.scopus.com/inward/record.url?scp=77955769047&partnerID=8YFLogxK
U2 - 10.1016/j.carres.2010.01.024
DO - 10.1016/j.carres.2010.01.024
M3 - Conference paper
VL - 345
SP - 1377
EP - 1383
JO - Carbohydrate Research
JF - Carbohydrate Research
IS - 10
T2 - 15th European Carbohydrate Symposium
Y2 - 19 July 2009 through 24 July 2009
ER -
