Consortium neuroscience of attention deficit/hyperactivity disorder and autism spectrum disorder: The ENIGMA adventure

the ENIGMA-ADHD working group; the ENIGMA-ASD working group; Martine Hoogman; Daan  van Rooij; Marieke Klein; Premika S.  Boedhoe; Iva  lioska; Ting  Li; Yashma Patel; Merel C Postema; Yanli Zhang-James; Evdokia Anagnostou; Celso Arango; Guillaume Auzias; Tobias Banaschewski; Claiton H D Bau; Marlene Behrmann; Mark A. Bellgrove; Daniel Brandeis; Silvia Brem; Geraldo F. Busatto; Sara Calderoni; Rosa Calvo; Francisco X Castellanos; David Coghill; Annette Conzelmann; Eileen Daly; Christine Deruelle; Ilan Dinstein; Sarah Durston; Christine Ecker; Stefan Ehrlich; Jeffery N.  Epstein; Damien A. Fair; Jacqueline  Fitzgerald; Christine M. Freitag; Thomas Frodl; Louise Gallagher; Eugenio H. Greve; Jan Haavik; Pieter J. Hoekstra; Joost Janssen; Georgii  Karkashadze; Joseph A.  King; Kerstin Konrad; Jonna Kuntsi; Luisa Lazaro; Jason P Lerch; Klaus-Peter Lesch; Mario R.  Louza; Beatriz Luna; Paulo Mattos; Jane McGrath; Filippo Muratori; Clodagh Murphy; Joel T. Nigg; Eileen  Oberwelland-Weiss; Ruth L.  O'Gorman Tuura; Kirsten O'Hearn; Jaap Oosterlaan; Mara Parellada; Paul Pauli; Kerstin J. Plessen; Josep Antoni Ramos-Quiroga; Andreas Reif; Liesbeth Reneman; Alessandra Retico; Pedro G. P. Rosa; Katya Rubia; Philip Shaw; Tim J. Silk; Leanne Tamm; Oscar Vilarroya; Susanne Walitza; Neda Jahanshad; Stephen V. Faraone; Clyde Francks; Odile A. van den Heuvel; Tomas Paus; Paul M. Thompson; Jan K. Buitelaar; Barbara Franke

doi:10.1002/hbm.25029

Consortium neuroscience of attention deficit/hyperactivity disorder and autism spectrum disorder: The ENIGMA adventure

the ENIGMA-ADHD working group, the ENIGMA-ASD working group, Martine Hoogman, Daan van Rooij , Marieke Klein, Premika S. Boedhoe , Iva lioska, Ting Li, Yashma Patel, Merel C Postema, Yanli Zhang-James, Evdokia Anagnostou, Celso Arango, Guillaume Auzias, Tobias Banaschewski, Claiton H D Bau, Marlene Behrmann, Mark A. Bellgrove, Daniel Brandeis, Silvia BremGeraldo F. Busatto, Sara Calderoni, Rosa Calvo, Francisco X Castellanos, David Coghill, Annette Conzelmann, Eileen Daly, Christine Deruelle, Ilan Dinstein, Sarah Durston, Christine Ecker, Stefan Ehrlich, Jeffery N. Epstein, Damien A. Fair, Jacqueline Fitzgerald, Christine M. Freitag, Thomas Frodl, Louise Gallagher, Eugenio H. Greve, Jan Haavik, Pieter J. Hoekstra, Joost Janssen, Georgii Karkashadze, Joseph A. King, Kerstin Konrad, Jonna Kuntsi, Luisa Lazaro, Jason P Lerch, Klaus-Peter Lesch, Mario R. Louza, Beatriz Luna, Paulo Mattos, Jane McGrath, Filippo Muratori, Clodagh Murphy, Joel T. Nigg, Eileen Oberwelland-Weiss, Ruth L. O'Gorman Tuura, Kirsten O'Hearn, Jaap Oosterlaan, Mara Parellada, Paul Pauli, Kerstin J. Plessen, Josep Antoni Ramos-Quiroga, Andreas Reif, Liesbeth Reneman, Alessandra Retico, Pedro G. P. Rosa, Katya Rubia, Philip Shaw, Tim J. Silk, Leanne Tamm, Oscar Vilarroya, Susanne Walitza, Neda Jahanshad, Stephen V. Faraone, Clyde Francks, Odile A. van den Heuvel, Tomas Paus, Paul M. Thompson, Jan K. Buitelaar, Barbara Franke

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Abstract

Neuroimaging has been extensively used to study brain structure and function in individuals with attention deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) over the past decades. Two of the main shortcomings of the neuroimaging literature of these disorders are the small sample sizes employed and the heterogeneity of methods used. In 2013 and 2014, the ENIGMA‐ADHD and ENIGMA‐ASD working groups were respectively, founded with a common goal to address these limitations. Here, we provide a narrative review of the thus far completed and still ongoing projects of these working groups. Due to an implicitly hierarchical psychiatric diagnostic classification system, the fields of ADHD and ASD have developed largely in isolation, despite the considerable overlap in the occurrence of the disorders. The collaboration between the ENIGMA‐ADHD and ‐ASD working groups seeks to bring the neuroimaging efforts of the two disorders closer together. The outcomes of case–control studies of subcortical and cortical structures showed that subcortical volumes are similarly affected in ASD and ADHD, albeit with small effect sizes. Cortical analyses identified unique differences in each disorder, but also considerable overlap between the two, specifically in cortical thickness. Ongoing work is examining alternative research questions, such as brain laterality, prediction of case–control status, and anatomical heterogeneity. In brief, great strides have been made toward fulfilling the aims of the ENIGMA collaborations, while new ideas and follow‐up analyses continue that include more imaging modalities (diffusion MRI and resting‐state functional MRI), collaborations with other large databases, and samples with dual diagnoses.

Original language	English
Journal	Human Brain Mapping
Early online date	18 May 2020
DOIs	https://doi.org/10.1002/hbm.25029
Publication status	E-pub ahead of print - 18 May 2020

Keywords

ADHD
ASD
ENIGMA
cortex
neuroimaging
subcortical volumes

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the ENIGMA-ADHD working group, the ENIGMA-ASD working group, Hoogman, M., van Rooij , D., Klein, M., Boedhoe , P. S., lioska, I., Li, T., Patel, Y., Postema, M. C., Zhang-James, Y., Anagnostou, E., Arango, C., Auzias, G., Banaschewski, T., Bau, C. H. D., Behrmann, M., Bellgrove, M. A., Brandeis, D., ... Franke, B. (2020). Consortium neuroscience of attention deficit/hyperactivity disorder and autism spectrum disorder: The ENIGMA adventure. Human Brain Mapping. Advance online publication. https://doi.org/10.1002/hbm.25029

@article{65d46eef3bb440d19c702142a74eb596,

title = "Consortium neuroscience of attention deficit/hyperactivity disorder and autism spectrum disorder: The ENIGMA adventure",

abstract = "Neuroimaging has been extensively used to study brain structure and function in individuals with attention deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) over the past decades. Two of the main shortcomings of the neuroimaging literature of these disorders are the small sample sizes employed and the heterogeneity of methods used. In 2013 and 2014, the ENIGMA‐ADHD and ENIGMA‐ASD working groups were respectively, founded with a common goal to address these limitations. Here, we provide a narrative review of the thus far completed and still ongoing projects of these working groups. Due to an implicitly hierarchical psychiatric diagnostic classification system, the fields of ADHD and ASD have developed largely in isolation, despite the considerable overlap in the occurrence of the disorders. The collaboration between the ENIGMA‐ADHD and ‐ASD working groups seeks to bring the neuroimaging efforts of the two disorders closer together. The outcomes of case–control studies of subcortical and cortical structures showed that subcortical volumes are similarly affected in ASD and ADHD, albeit with small effect sizes. Cortical analyses identified unique differences in each disorder, but also considerable overlap between the two, specifically in cortical thickness. Ongoing work is examining alternative research questions, such as brain laterality, prediction of case–control status, and anatomical heterogeneity. In brief, great strides have been made toward fulfilling the aims of the ENIGMA collaborations, while new ideas and follow‐up analyses continue that include more imaging modalities (diffusion MRI and resting‐state functional MRI), collaborations with other large databases, and samples with dual diagnoses.",

keywords = "ADHD, ASD, ENIGMA, cortex, neuroimaging, subcortical volumes",

author = "{the ENIGMA-ADHD working group} and {the ENIGMA-ASD working group} and Martine Hoogman and {van Rooij}, Daan and Marieke Klein and Boedhoe, {Premika S.} and Iva lioska and Ting Li and Yashma Patel and Postema, {Merel C} and Yanli Zhang-James and Evdokia Anagnostou and Celso Arango and Guillaume Auzias and Tobias Banaschewski and Bau, {Claiton H D} and Marlene Behrmann and Bellgrove, {Mark A.} and Daniel Brandeis and Silvia Brem and Busatto, {Geraldo F.} and Sara Calderoni and Rosa Calvo and Castellanos, {Francisco X} and David Coghill and Annette Conzelmann and Eileen Daly and Christine Deruelle and Ilan Dinstein and Sarah Durston and Christine Ecker and Stefan Ehrlich and Epstein, {Jeffery N.} and Fair, {Damien A.} and Jacqueline Fitzgerald and Freitag, {Christine M.} and Thomas Frodl and Louise Gallagher and Greve, {Eugenio H.} and Jan Haavik and Hoekstra, {Pieter J.} and Joost Janssen and Georgii Karkashadze and King, {Joseph A.} and Kerstin Konrad and Jonna Kuntsi and Luisa Lazaro and Lerch, {Jason P} and Klaus-Peter Lesch and Louza, {Mario R.} and Beatriz Luna and Paulo Mattos and Jane McGrath and Filippo Muratori and Clodagh Murphy and Nigg, {Joel T.} and Eileen Oberwelland-Weiss and {O'Gorman Tuura}, {Ruth L.} and Kirsten O'Hearn and Jaap Oosterlaan and Mara Parellada and Paul Pauli and Plessen, {Kerstin J.} and {Antoni Ramos-Quiroga}, Josep and Andreas Reif and Liesbeth Reneman and Alessandra Retico and Rosa, {Pedro G. P.} and Katya Rubia and Philip Shaw and Silk, {Tim J.} and Leanne Tamm and Oscar Vilarroya and Susanne Walitza and Neda Jahanshad and Faraone, {Stephen V.} and Clyde Francks and {van den Heuvel}, {Odile A.} and Tomas Paus and Thompson, {Paul M.} and Buitelaar, {Jan K.} and Barbara Franke",

year = "2020",

month = may,

day = "18",

doi = "10.1002/hbm.25029",

language = "English",

journal = "Human Brain Mapping",

issn = "1065-9471",

publisher = "Wiley-Liss Inc.",

}

the ENIGMA-ADHD working group, the ENIGMA-ASD working group, Hoogman, M, van Rooij , D, Klein, M, Boedhoe , PS, lioska, I, Li, T, Patel, Y, Postema, MC, Zhang-James, Y, Anagnostou, E, Arango, C, Auzias, G, Banaschewski, T, Bau, CHD, Behrmann, M, Bellgrove, MA, Brandeis, D, Brem, S, Busatto, GF, Calderoni, S, Calvo, R, Castellanos, FX, Coghill, D, Conzelmann, A, Daly, E, Deruelle, C, Dinstein, I, Durston, S, Ecker, C, Ehrlich, S, Epstein, JN, Fair, DA, Fitzgerald, J, Freitag, CM, Frodl, T, Gallagher, L, Greve, EH, Haavik, J, Hoekstra, PJ, Janssen, J, Karkashadze, G, King, JA, Konrad, K, Kuntsi, J, Lazaro, L, Lerch, JP, Lesch, K-P, Louza, MR, Luna, B, Mattos, P, McGrath, J, Muratori, F, Murphy, C, Nigg, JT, Oberwelland-Weiss, E, O'Gorman Tuura, RL, O'Hearn, K, Oosterlaan, J, Parellada, M, Pauli, P, Plessen, KJ, Antoni Ramos-Quiroga, J, Reif, A, Reneman, L, Retico, A, Rosa, PGP, Rubia, K , Shaw, P, Silk, TJ, Tamm, L, Vilarroya, O, Walitza, S, Jahanshad, N, Faraone, SV, Francks, C, van den Heuvel, OA, Paus, T, Thompson, PM, Buitelaar, JK & Franke, B 2020, 'Consortium neuroscience of attention deficit/hyperactivity disorder and autism spectrum disorder: The ENIGMA adventure', Human Brain Mapping. https://doi.org/10.1002/hbm.25029

TY - JOUR

T1 - Consortium neuroscience of attention deficit/hyperactivity disorder and autism spectrum disorder

T2 - The ENIGMA adventure

AU - the ENIGMA-ADHD working group

AU - the ENIGMA-ASD working group

AU - Hoogman, Martine

AU - van Rooij , Daan

AU - Klein, Marieke

AU - Boedhoe , Premika S.

AU - lioska, Iva

AU - Li, Ting

AU - Patel, Yashma

AU - Postema, Merel C

AU - Zhang-James, Yanli

AU - Anagnostou, Evdokia

AU - Arango, Celso

AU - Auzias, Guillaume

AU - Banaschewski, Tobias

AU - Bau, Claiton H D

AU - Behrmann, Marlene

AU - Bellgrove, Mark A.

AU - Brandeis, Daniel

AU - Brem, Silvia

AU - Busatto, Geraldo F.

AU - Calderoni, Sara

AU - Calvo, Rosa

AU - Castellanos, Francisco X

AU - Coghill, David

AU - Conzelmann, Annette

AU - Daly, Eileen

AU - Deruelle, Christine

AU - Dinstein, Ilan

AU - Durston, Sarah

AU - Ecker, Christine

AU - Ehrlich, Stefan

AU - Epstein, Jeffery N.

AU - Fair, Damien A.

AU - Fitzgerald, Jacqueline

AU - Freitag, Christine M.

AU - Frodl, Thomas

AU - Gallagher, Louise

AU - Greve, Eugenio H.

AU - Haavik, Jan

AU - Hoekstra, Pieter J.

AU - Janssen, Joost

AU - Karkashadze, Georgii

AU - King, Joseph A.

AU - Konrad, Kerstin

AU - Kuntsi, Jonna

AU - Lazaro, Luisa

AU - Lerch, Jason P

AU - Lesch, Klaus-Peter

AU - Louza, Mario R.

AU - Luna, Beatriz

AU - Mattos, Paulo

AU - McGrath, Jane

AU - Muratori, Filippo

AU - Murphy, Clodagh

AU - Nigg, Joel T.

AU - Oberwelland-Weiss, Eileen

AU - O'Gorman Tuura, Ruth L.

AU - O'Hearn, Kirsten

AU - Oosterlaan, Jaap

AU - Parellada, Mara

AU - Pauli, Paul

AU - Plessen, Kerstin J.

AU - Antoni Ramos-Quiroga, Josep

AU - Reif, Andreas

AU - Reneman, Liesbeth

AU - Retico, Alessandra

AU - Rosa, Pedro G. P.

AU - Rubia, Katya

AU - Shaw, Philip

AU - Silk, Tim J.

AU - Tamm, Leanne

AU - Vilarroya, Oscar

AU - Walitza, Susanne

AU - Jahanshad, Neda

AU - Faraone, Stephen V.

AU - Francks, Clyde

AU - van den Heuvel, Odile A.

AU - Paus, Tomas

AU - Thompson, Paul M.

AU - Buitelaar, Jan K.

AU - Franke, Barbara

PY - 2020/5/18

Y1 - 2020/5/18

N2 - Neuroimaging has been extensively used to study brain structure and function in individuals with attention deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) over the past decades. Two of the main shortcomings of the neuroimaging literature of these disorders are the small sample sizes employed and the heterogeneity of methods used. In 2013 and 2014, the ENIGMA‐ADHD and ENIGMA‐ASD working groups were respectively, founded with a common goal to address these limitations. Here, we provide a narrative review of the thus far completed and still ongoing projects of these working groups. Due to an implicitly hierarchical psychiatric diagnostic classification system, the fields of ADHD and ASD have developed largely in isolation, despite the considerable overlap in the occurrence of the disorders. The collaboration between the ENIGMA‐ADHD and ‐ASD working groups seeks to bring the neuroimaging efforts of the two disorders closer together. The outcomes of case–control studies of subcortical and cortical structures showed that subcortical volumes are similarly affected in ASD and ADHD, albeit with small effect sizes. Cortical analyses identified unique differences in each disorder, but also considerable overlap between the two, specifically in cortical thickness. Ongoing work is examining alternative research questions, such as brain laterality, prediction of case–control status, and anatomical heterogeneity. In brief, great strides have been made toward fulfilling the aims of the ENIGMA collaborations, while new ideas and follow‐up analyses continue that include more imaging modalities (diffusion MRI and resting‐state functional MRI), collaborations with other large databases, and samples with dual diagnoses.

AB - Neuroimaging has been extensively used to study brain structure and function in individuals with attention deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) over the past decades. Two of the main shortcomings of the neuroimaging literature of these disorders are the small sample sizes employed and the heterogeneity of methods used. In 2013 and 2014, the ENIGMA‐ADHD and ENIGMA‐ASD working groups were respectively, founded with a common goal to address these limitations. Here, we provide a narrative review of the thus far completed and still ongoing projects of these working groups. Due to an implicitly hierarchical psychiatric diagnostic classification system, the fields of ADHD and ASD have developed largely in isolation, despite the considerable overlap in the occurrence of the disorders. The collaboration between the ENIGMA‐ADHD and ‐ASD working groups seeks to bring the neuroimaging efforts of the two disorders closer together. The outcomes of case–control studies of subcortical and cortical structures showed that subcortical volumes are similarly affected in ASD and ADHD, albeit with small effect sizes. Cortical analyses identified unique differences in each disorder, but also considerable overlap between the two, specifically in cortical thickness. Ongoing work is examining alternative research questions, such as brain laterality, prediction of case–control status, and anatomical heterogeneity. In brief, great strides have been made toward fulfilling the aims of the ENIGMA collaborations, while new ideas and follow‐up analyses continue that include more imaging modalities (diffusion MRI and resting‐state functional MRI), collaborations with other large databases, and samples with dual diagnoses.

KW - ADHD

KW - ASD

KW - ENIGMA

KW - cortex

KW - neuroimaging

KW - subcortical volumes

UR - http://www.scopus.com/inward/record.url?scp=85084801312&partnerID=8YFLogxK

U2 - 10.1002/hbm.25029

DO - 10.1002/hbm.25029

M3 - Review article

SN - 1065-9471

JO - Human Brain Mapping

JF - Human Brain Mapping

ER -

Consortium neuroscience of attention deficit/hyperactivity disorder and autism spectrum disorder: The ENIGMA adventure

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