Consortium on Vulnerability to Externalizing Disorders and Addictions (cVEDA): A developmental cohort study protocol

Eesha Sharma; Preeti Jacob; Pratima Murthy; Sanjeev Jain; Mathew Varghese; Deepak Jayarajan; Keshav Kumar; Vivek Benegal; Nilakshi Vaidya; Yuning Zhang; Sylvane Desrivieres; Gunter Schumann; Udita Iyengar; Bharath Holla; Meera Purushottam; Amit Chakrabarti; Gwen Sascha Fernandes; Jon Heron; Matthew Hickman; Kamakshi Kartik; Kartik Kalyanram; Madhavi Rangaswamy; Rose Dawn Bharath; Gareth Barker; Dimitri Papadopoulos Orfanos; Chirag Ahuja; Kandavel Thennarasu; Debashish Basu; B. N. Subodh; Rebecca Kuriyan; Sunita Simon Kurpad; Kalyanaraman Kumaran; Ghattu Krishnaveni; Murali Krishna; Rajkumar Lenin Singh; L. Roshan Singh; Mireille Toledano

doi:10.1186/s12888-019-2373-3

Consortium on Vulnerability to Externalizing Disorders and Addictions (cVEDA): A developmental cohort study protocol

Eesha Sharma^*, Preeti Jacob, Pratima Murthy, Sanjeev Jain, Mathew Varghese, Deepak Jayarajan, Keshav Kumar, Vivek Benegal, Nilakshi Vaidya, Yuning Zhang, Sylvane Desrivieres, Gunter Schumann, Udita Iyengar, Bharath Holla, Meera Purushottam, Amit Chakrabarti, Gwen Sascha Fernandes, Jon Heron, Matthew Hickman, Kamakshi KartikKartik Kalyanram, Madhavi Rangaswamy, Rose Dawn Bharath, Gareth Barker, Dimitri Papadopoulos Orfanos, Chirag Ahuja, Kandavel Thennarasu, Debashish Basu, B. N. Subodh, Rebecca Kuriyan, Sunita Simon Kurpad, Kalyanaraman Kumaran, Ghattu Krishnaveni, Murali Krishna, Rajkumar Lenin Singh, L. Roshan Singh, Mireille Toledano

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

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Abstract

Background: Low and middle-income countries like India with a large youth population experience a different environment from that of high-income countries. The Consortium on Vulnerability to Externalizing Disorders and Addictions (cVEDA), based in India, aims to examine environmental influences on genomic variations, neurodevelopmental trajectories and vulnerability to psychopathology, with a focus on externalizing disorders. Methods: cVEDA is a longitudinal cohort study, with planned missingness design for yearly follow-up. Participants have been recruited from multi-site tertiary care mental health settings, local communities, schools and colleges. 10,000 individuals between 6 and 23 years of age, of all genders, representing five geographically, ethnically, and socio-culturally distinct regions in India, and exposures to variations in early life adversity (psychosocial, nutritional, toxic exposures, slum-habitats, socio-political conflicts, urban/rural living, mental illness in the family) have been assessed using age-appropriate instruments to capture socio-demographic information, temperament, environmental exposures, parenting, psychiatric morbidity, and neuropsychological functioning. Blood/saliva and urine samples have been collected for genetic, epigenetic and toxicological (heavy metals, volatile organic compounds) studies. Structural (T1, T2, DTI) and functional (resting state fMRI) MRI brain scans have been performed on approximately 15% of the individuals. All data and biological samples are maintained in a databank and biobank, respectively. Discussion: The cVEDA has established the largest neurodevelopmental database in India, comparable to global datasets, with detailed environmental characterization. This should permit identification of environmental and genetic vulnerabilities to psychopathology within a developmental framework. Neuroimaging and neuropsychological data from this study are already yielding insights on brain growth and maturation patterns.

Original language	English
Article number	2
Journal	BMC Psychiatry
Volume	20
Issue number	1
DOIs	https://doi.org/10.1186/s12888-019-2373-3
Publication status	Published - 2 Jan 2020

Keywords

Cohort
Environmental exposures
Externalizing disorders
Longitudinal study
Study protocol
Vulnerabilities

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Consortium on Vulnerability_SHARMA_Accepted26Nov2019_GOLD VORFinal published version, 1.16 MBLicence: CC BY

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Sharma, E., Jacob, P., Murthy, P., Jain, S., Varghese, M., Jayarajan, D., Kumar, K., Benegal, V., Vaidya, N., Zhang, Y., Desrivieres, S., Schumann, G., Iyengar, U., Holla, B., Purushottam, M., Chakrabarti, A., Fernandes, G. S., Heron, J., Hickman, M., ... Toledano, M. (2020). Consortium on Vulnerability to Externalizing Disorders and Addictions (cVEDA): A developmental cohort study protocol. BMC Psychiatry, 20(1), Article 2. https://doi.org/10.1186/s12888-019-2373-3

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title = "Consortium on Vulnerability to Externalizing Disorders and Addictions (cVEDA): A developmental cohort study protocol",

abstract = "Background: Low and middle-income countries like India with a large youth population experience a different environment from that of high-income countries. The Consortium on Vulnerability to Externalizing Disorders and Addictions (cVEDA), based in India, aims to examine environmental influences on genomic variations, neurodevelopmental trajectories and vulnerability to psychopathology, with a focus on externalizing disorders. Methods: cVEDA is a longitudinal cohort study, with planned missingness design for yearly follow-up. Participants have been recruited from multi-site tertiary care mental health settings, local communities, schools and colleges. 10,000 individuals between 6 and 23 years of age, of all genders, representing five geographically, ethnically, and socio-culturally distinct regions in India, and exposures to variations in early life adversity (psychosocial, nutritional, toxic exposures, slum-habitats, socio-political conflicts, urban/rural living, mental illness in the family) have been assessed using age-appropriate instruments to capture socio-demographic information, temperament, environmental exposures, parenting, psychiatric morbidity, and neuropsychological functioning. Blood/saliva and urine samples have been collected for genetic, epigenetic and toxicological (heavy metals, volatile organic compounds) studies. Structural (T1, T2, DTI) and functional (resting state fMRI) MRI brain scans have been performed on approximately 15% of the individuals. All data and biological samples are maintained in a databank and biobank, respectively. Discussion: The cVEDA has established the largest neurodevelopmental database in India, comparable to global datasets, with detailed environmental characterization. This should permit identification of environmental and genetic vulnerabilities to psychopathology within a developmental framework. Neuroimaging and neuropsychological data from this study are already yielding insights on brain growth and maturation patterns.",

keywords = "Cohort, Environmental exposures, Externalizing disorders, Longitudinal study, Study protocol, Vulnerabilities",

author = "Eesha Sharma and Preeti Jacob and Pratima Murthy and Sanjeev Jain and Mathew Varghese and Deepak Jayarajan and Keshav Kumar and Vivek Benegal and Nilakshi Vaidya and Yuning Zhang and Sylvane Desrivieres and Gunter Schumann and Udita Iyengar and Bharath Holla and Meera Purushottam and Amit Chakrabarti and Fernandes, {Gwen Sascha} and Jon Heron and Matthew Hickman and Kamakshi Kartik and Kartik Kalyanram and Madhavi Rangaswamy and Bharath, {Rose Dawn} and Gareth Barker and Orfanos, {Dimitri Papadopoulos} and Chirag Ahuja and Kandavel Thennarasu and Debashish Basu and Subodh, {B. N.} and Rebecca Kuriyan and Kurpad, {Sunita Simon} and Kalyanaraman Kumaran and Ghattu Krishnaveni and Murali Krishna and Singh, {Rajkumar Lenin} and Singh, {L. Roshan} and Mireille Toledano",

year = "2020",

month = jan,

day = "2",

doi = "10.1186/s12888-019-2373-3",

language = "English",

volume = "20",

journal = "BMC Psychiatry",

issn = "1471-244X",

publisher = "BioMed Central",

number = "1",

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Sharma, E, Jacob, P, Murthy, P, Jain, S, Varghese, M, Jayarajan, D, Kumar, K, Benegal, V, Vaidya, N, Zhang, Y , Desrivieres, S , Schumann, G , Iyengar, U, Holla, B, Purushottam, M, Chakrabarti, A, Fernandes, GS, Heron, J, Hickman, M, Kartik, K, Kalyanram, K, Rangaswamy, M, Bharath, RD, Barker, G, Orfanos, DP, Ahuja, C, Thennarasu, K, Basu, D, Subodh, BN, Kuriyan, R, Kurpad, SS, Kumaran, K, Krishnaveni, G, Krishna, M, Singh, RL, Singh, LR & Toledano, M 2020, 'Consortium on Vulnerability to Externalizing Disorders and Addictions (cVEDA): A developmental cohort study protocol', BMC Psychiatry, vol. 20, no. 1, 2. https://doi.org/10.1186/s12888-019-2373-3

TY - JOUR

T1 - Consortium on Vulnerability to Externalizing Disorders and Addictions (cVEDA)

T2 - A developmental cohort study protocol

AU - Sharma, Eesha

AU - Jacob, Preeti

AU - Murthy, Pratima

AU - Jain, Sanjeev

AU - Varghese, Mathew

AU - Jayarajan, Deepak

AU - Kumar, Keshav

AU - Benegal, Vivek

AU - Vaidya, Nilakshi

AU - Zhang, Yuning

AU - Desrivieres, Sylvane

AU - Schumann, Gunter

AU - Iyengar, Udita

AU - Holla, Bharath

AU - Purushottam, Meera

AU - Chakrabarti, Amit

AU - Fernandes, Gwen Sascha

AU - Heron, Jon

AU - Hickman, Matthew

AU - Kartik, Kamakshi

AU - Kalyanram, Kartik

AU - Rangaswamy, Madhavi

AU - Bharath, Rose Dawn

AU - Barker, Gareth

AU - Orfanos, Dimitri Papadopoulos

AU - Ahuja, Chirag

AU - Thennarasu, Kandavel

AU - Basu, Debashish

AU - Subodh, B. N.

AU - Kuriyan, Rebecca

AU - Kurpad, Sunita Simon

AU - Kumaran, Kalyanaraman

AU - Krishnaveni, Ghattu

AU - Krishna, Murali

AU - Singh, Rajkumar Lenin

AU - Singh, L. Roshan

AU - Toledano, Mireille

PY - 2020/1/2

Y1 - 2020/1/2

N2 - Background: Low and middle-income countries like India with a large youth population experience a different environment from that of high-income countries. The Consortium on Vulnerability to Externalizing Disorders and Addictions (cVEDA), based in India, aims to examine environmental influences on genomic variations, neurodevelopmental trajectories and vulnerability to psychopathology, with a focus on externalizing disorders. Methods: cVEDA is a longitudinal cohort study, with planned missingness design for yearly follow-up. Participants have been recruited from multi-site tertiary care mental health settings, local communities, schools and colleges. 10,000 individuals between 6 and 23 years of age, of all genders, representing five geographically, ethnically, and socio-culturally distinct regions in India, and exposures to variations in early life adversity (psychosocial, nutritional, toxic exposures, slum-habitats, socio-political conflicts, urban/rural living, mental illness in the family) have been assessed using age-appropriate instruments to capture socio-demographic information, temperament, environmental exposures, parenting, psychiatric morbidity, and neuropsychological functioning. Blood/saliva and urine samples have been collected for genetic, epigenetic and toxicological (heavy metals, volatile organic compounds) studies. Structural (T1, T2, DTI) and functional (resting state fMRI) MRI brain scans have been performed on approximately 15% of the individuals. All data and biological samples are maintained in a databank and biobank, respectively. Discussion: The cVEDA has established the largest neurodevelopmental database in India, comparable to global datasets, with detailed environmental characterization. This should permit identification of environmental and genetic vulnerabilities to psychopathology within a developmental framework. Neuroimaging and neuropsychological data from this study are already yielding insights on brain growth and maturation patterns.

AB - Background: Low and middle-income countries like India with a large youth population experience a different environment from that of high-income countries. The Consortium on Vulnerability to Externalizing Disorders and Addictions (cVEDA), based in India, aims to examine environmental influences on genomic variations, neurodevelopmental trajectories and vulnerability to psychopathology, with a focus on externalizing disorders. Methods: cVEDA is a longitudinal cohort study, with planned missingness design for yearly follow-up. Participants have been recruited from multi-site tertiary care mental health settings, local communities, schools and colleges. 10,000 individuals between 6 and 23 years of age, of all genders, representing five geographically, ethnically, and socio-culturally distinct regions in India, and exposures to variations in early life adversity (psychosocial, nutritional, toxic exposures, slum-habitats, socio-political conflicts, urban/rural living, mental illness in the family) have been assessed using age-appropriate instruments to capture socio-demographic information, temperament, environmental exposures, parenting, psychiatric morbidity, and neuropsychological functioning. Blood/saliva and urine samples have been collected for genetic, epigenetic and toxicological (heavy metals, volatile organic compounds) studies. Structural (T1, T2, DTI) and functional (resting state fMRI) MRI brain scans have been performed on approximately 15% of the individuals. All data and biological samples are maintained in a databank and biobank, respectively. Discussion: The cVEDA has established the largest neurodevelopmental database in India, comparable to global datasets, with detailed environmental characterization. This should permit identification of environmental and genetic vulnerabilities to psychopathology within a developmental framework. Neuroimaging and neuropsychological data from this study are already yielding insights on brain growth and maturation patterns.

KW - Cohort

KW - Environmental exposures

KW - Externalizing disorders

KW - Longitudinal study

KW - Study protocol

KW - Vulnerabilities

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U2 - 10.1186/s12888-019-2373-3

DO - 10.1186/s12888-019-2373-3

M3 - Article

C2 - 31898525

AN - SCOPUS:85077382480

SN - 1471-244X

VL - 20

JO - BMC Psychiatry

JF - BMC Psychiatry

IS - 1

M1 - 2

ER -

Consortium on Vulnerability to Externalizing Disorders and Addictions (cVEDA): A developmental cohort study protocol

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Keywords

UN SDGs

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