Consortium on Vulnerability to Externalizing Disorders and Addictions (cVEDA): A developmental cohort study protocol

TY - JOUR

T1 - Consortium on Vulnerability to Externalizing Disorders and Addictions (cVEDA)

T2 - A developmental cohort study protocol

AU - Sharma, Eesha

AU - Jacob, Preeti

AU - Murthy, Pratima

AU - Jain, Sanjeev

AU - Varghese, Mathew

AU - Jayarajan, Deepak

AU - Kumar, Keshav

AU - Benegal, Vivek

AU - Vaidya, Nilakshi

AU - Zhang, Yuning

AU - Desrivieres, Sylvane

AU - Schumann, Gunter

AU - Iyengar, Udita

AU - Holla, Bharath

AU - Purushottam, Meera

AU - Chakrabarti, Amit

AU - Fernandes, Gwen Sascha

AU - Heron, Jon

AU - Hickman, Matthew

AU - Kartik, Kamakshi

AU - Kalyanram, Kartik

AU - Rangaswamy, Madhavi

AU - Bharath, Rose Dawn

AU - Barker, Gareth

AU - Orfanos, Dimitri Papadopoulos

AU - Ahuja, Chirag

AU - Thennarasu, Kandavel

AU - Basu, Debashish

AU - Subodh, B. N.

AU - Kuriyan, Rebecca

AU - Kurpad, Sunita Simon

AU - Kumaran, Kalyanaraman

AU - Krishnaveni, Ghattu

AU - Krishna, Murali

AU - Singh, Rajkumar Lenin

AU - Singh, L. Roshan

AU - Toledano, Mireille

PY - 2020/1/2

Y1 - 2020/1/2

N2 - Background: Low and middle-income countries like India with a large youth population experience a different environment from that of high-income countries. The Consortium on Vulnerability to Externalizing Disorders and Addictions (cVEDA), based in India, aims to examine environmental influences on genomic variations, neurodevelopmental trajectories and vulnerability to psychopathology, with a focus on externalizing disorders. Methods: cVEDA is a longitudinal cohort study, with planned missingness design for yearly follow-up. Participants have been recruited from multi-site tertiary care mental health settings, local communities, schools and colleges. 10,000 individuals between 6 and 23 years of age, of all genders, representing five geographically, ethnically, and socio-culturally distinct regions in India, and exposures to variations in early life adversity (psychosocial, nutritional, toxic exposures, slum-habitats, socio-political conflicts, urban/rural living, mental illness in the family) have been assessed using age-appropriate instruments to capture socio-demographic information, temperament, environmental exposures, parenting, psychiatric morbidity, and neuropsychological functioning. Blood/saliva and urine samples have been collected for genetic, epigenetic and toxicological (heavy metals, volatile organic compounds) studies. Structural (T1, T2, DTI) and functional (resting state fMRI) MRI brain scans have been performed on approximately 15% of the individuals. All data and biological samples are maintained in a databank and biobank, respectively. Discussion: The cVEDA has established the largest neurodevelopmental database in India, comparable to global datasets, with detailed environmental characterization. This should permit identification of environmental and genetic vulnerabilities to psychopathology within a developmental framework. Neuroimaging and neuropsychological data from this study are already yielding insights on brain growth and maturation patterns.

AB - Background: Low and middle-income countries like India with a large youth population experience a different environment from that of high-income countries. The Consortium on Vulnerability to Externalizing Disorders and Addictions (cVEDA), based in India, aims to examine environmental influences on genomic variations, neurodevelopmental trajectories and vulnerability to psychopathology, with a focus on externalizing disorders. Methods: cVEDA is a longitudinal cohort study, with planned missingness design for yearly follow-up. Participants have been recruited from multi-site tertiary care mental health settings, local communities, schools and colleges. 10,000 individuals between 6 and 23 years of age, of all genders, representing five geographically, ethnically, and socio-culturally distinct regions in India, and exposures to variations in early life adversity (psychosocial, nutritional, toxic exposures, slum-habitats, socio-political conflicts, urban/rural living, mental illness in the family) have been assessed using age-appropriate instruments to capture socio-demographic information, temperament, environmental exposures, parenting, psychiatric morbidity, and neuropsychological functioning. Blood/saliva and urine samples have been collected for genetic, epigenetic and toxicological (heavy metals, volatile organic compounds) studies. Structural (T1, T2, DTI) and functional (resting state fMRI) MRI brain scans have been performed on approximately 15% of the individuals. All data and biological samples are maintained in a databank and biobank, respectively. Discussion: The cVEDA has established the largest neurodevelopmental database in India, comparable to global datasets, with detailed environmental characterization. This should permit identification of environmental and genetic vulnerabilities to psychopathology within a developmental framework. Neuroimaging and neuropsychological data from this study are already yielding insights on brain growth and maturation patterns.

KW - Cohort

KW - Environmental exposures

KW - Externalizing disorders

KW - Longitudinal study

KW - Study protocol

KW - Vulnerabilities

UR - https://www.scopus.com/pages/publications/85077382480

U2 - 10.1186/s12888-019-2373-3

DO - 10.1186/s12888-019-2373-3

M3 - Article

C2 - 31898525

AN - SCOPUS:85077382480

SN - 1471-244X

VL - 20

JO - BMC Psychiatry

JF - BMC Psychiatry

IS - 1

M1 - 2

ER -